U.S. Department of Health and Human Services
Rodolfo Ghirlando

 Contact Info

Tel: 301-451-8158
Email: rodolfog@intra.niddk.nih.gov

 Select Experience

  • Poste Vert FellowINSERM (National Institute of Health and Medical Research)1997
  • Visiting FellowNIDDK, NIH1995
  • Ph.D.Weizmann Institute of Science1991
  • B.Sc.University of the Witwatersrand1984
  • B.Sc. (Hons)University of the Witwatersrand1985

 Related Links


Rodolfo Ghirlando, Ph.D.

Staff Scientist, Office of the Chief, Laboratory of Molecular Biology
  • Biomedical Engineering/Biophysics/Physics
  • Molecular Biology/Biochemistry
Research Summary/In Plain Language

Research in Plain Language

The human genome (DNA) provides the complete code for our genetic information. Even though its recent decoding has proven to be very useful, the information provided still needs to be understood in more detail. We are interested in learning more about the three-dimensional structure of chromatin, the combination of DNA and proteins that make up the contents of the cell nucleus. In particular, we want to better understand how the structure of chromatin is related to activation or inactivation of specific regions of the genome. Gene activity or inactivity gives the cell control over structure and function, and helps cells develop and assemble to form the molecular machines that keep an organism alive. An understanding of these molecular machines requires a keen understanding of the chemical and biological processes involved deep within the cell—processes that translate gene activity into cellular action. We can learn more about these processes by studying the interactions of chromatin and its specific proteins. The results of our studies can help other scientists use this information to combat human disease.