U.S. Department of Health and Human Services

 Contact Info

Tel: 301-827-4202
Email: ouwerkerkr@mail.nih.gov

 Select Experience

  • Ph.D.Heamatolgy Department, School of Medicine, State University Utrecht, the Netherlands1989
  • M.S.Department of Chemistry, State University Utrecht, the Netherlands1986
  • B.S.Department of Chemistry, State University Utrecht, the Netherlands1984

 Related Links


Ronald Ouwerkerk, Ph.D.

Scientific Scientist, Biomedical and Metabolic Imaging Branch

Specialties: Biomedical Engineering/Biophysics/Physics, Chemistry/Chemical Biology, Medical Imaging and Magnetic Resonance Imaging​​​​​​​​​

Ronald Ouwerkerk, Ph.D.

Staff Scientist
  • Biomedical Engineering/Biophysics/Physics
  • Chemistry/Chemical Biology
  • Medical Imaging and Magnetic Resonance Imaging


A selection of recent and significant publications can be viewed below.

Muniyappa R, Sable S, Ouwerkerk R, Mari A, Gharib AM, Walter M, Courville A, Hall G, Chen KY, Volkow ND, Kunos G, Huestis MA, Skarulis MC. Metabolic effects of chronic cannabis smoking. Diabetes Care. 2013 Aug; 36 (8; 2013 Aug; 36):2415-22. [Full Text/Abstract]
Zhu H, Soher BJ, Ouwerkerk R, Schär M, Barker PB. Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses. Magn Reson Med. 2013 May; 69 (69; 2013 May; 5):1217-25. [Full Text/Abstract]
Ouwerkerk R, Pettigrew RI, Gharib AM. Liver metabolite concentrations measured with 1H MR spectroscopy. Radiology. 2012 Nov; 265 (2; 265; 2012 Nov):565-75. [Full Text/Abstract]
Barnett BP, Ruiz-Cabello J, Hota P, Ouwerkerk R, Shamblott MJ, Lauzon C, Walczak P, Gilson WD, Chacko VP, Kraitchman DL, Arepally A, Bulte JW. Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets. Contrast Media Mol Imaging. 2011 Jul-Aug; 6 (2011 Jul-Aug; 6; 4):251-9. [Full Text/Abstract]
Jacobs MA, Ouwerkerk R, Wolff AC, Gabrielson E, Warzecha H, Jeter S, Bluemke DA, Wahl R, Stearns V. Monitoring of neoadjuvant chemotherapy using multiparametric, ²³Na sodium MR, and multimodality (PET/CT/MRI) imaging in locally advanced breast cancer. Breast Cancer Res Treat. 2011 Jul; 128 (128; 2011 Jul; 1):119-26. [Full Text/Abstract]
Zhu H, Edden RA, Ouwerkerk R, Barker PB. High resolution spectroscopic imaging of GABA at 3 Tesla. Magn Reson Med. 2011 Mar; 65 (2011 Mar; 3; 65):603-9. [Full Text/Abstract]
Ouwerkerk R. Sodium MRI. Methods Mol Biol. 2011; 711 (2011; 711):175-201. [Full Text/Abstract]
Jacobs MA, Stearns V, Wolff AC, Macura K, Argani P, Khouri N, Tsangaris T, Barker PB, Davidson NE, Bhujwalla ZM, Bluemke DA, Ouwerkerk R. Multiparametric magnetic resonance imaging, spectroscopy and multinuclear (²³Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer. Acad Radiol. 2010 Dec; 17 (17; 2010 Dec; 12):1477-85. [Full Text/Abstract]
Zhu H, Ouwerkerk R, Barker PB. Dual-band water and lipid suppression for MR spectroscopic imaging at 3 Tesla. Magn Reson Med. 2010 Jun; 63 (2010 Jun; 6; 63):1486-92. [Full Text/Abstract]
Liu CY, Redheuil A, Ouwerkerk R, Lima JA, Bluemke DA. Myocardial fat quantification in humans: Evaluation by two-point water-fat imaging and localized proton spectroscopy. Magn Reson Med. 2010 Apr; 63 (4; 63; 2010 Apr):892-901. [Full Text/Abstract]
Nezafat R, Ouwerkerk R, Derbyshire AJ, Stuber M, McVeigh ER. Spectrally selective B1-insensitive T2 magnetization preparation sequence. Magn Reson Med. 2009 Jun; 61 (6; 2009 Jun; 61):1326-35. [Full Text/Abstract]
El-Sharkawy AM, Schär M, Ouwerkerk R, Weiss RG, Bottomley PA. Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses. Magn Reson Med. 2009 Apr; 61 (2009 Apr; 4; 61):785-95. [Full Text/Abstract]
Jacobs MA, Ouwerkerk R, Kamel I, Bottomley PA, Bluemke DA, Kim HS. Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study. J Magn Reson Imaging. 2009 Mar; 29 (3; 29; 2009 Mar):649-56. [Full Text/Abstract]
Jacobs MA, Ouwerkerk R, Petrowski K, Macura KJ. Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer. Top Magn Reson Imaging. 2008 Dec; 19 (2008 Dec; 6; 19):261-72. [Full Text/Abstract]
Ouwerkerk R, Bottomley PA, Solaiyappan M, Spooner AE, Tomaselli GF, Wu KC, Weiss RG. Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study. Radiology. 2008 Jul; 248 (248; 2008 Jul; 1):88-96. [Full Text/Abstract]
Ouwerkerk R, Jacobs MA, Macura KJ, Wolff AC, Stearns V, Mezban SD, Khouri NF, Bluemke DA, Bottomley PA. Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI. Breast Cancer Res Treat. 2007 Dec; 106 (106; 2; 2007 Dec):151-60. [Full Text/Abstract]
Ouwerkerk R. Sodium magnetic resonance imaging: from research to clinical use. J Am Coll Radiol. 2007 Oct; 4 (2007 Oct; 4; 10):739-41. [Full Text/Abstract]
Jacobs MA, Ibrahim TS, Ouwerkerk R. AAPM/RSNA physics tutorials for residents: MR imaging: brief overview and emerging applications. Radiographics. 2007 Jul-Aug; 27 (27; 4; 2007 Jul-Aug):1213-29. [Full Text/Abstract]
Macura KJ, Ouwerkerk R, Jacobs MA, Bluemke DA. Patterns of enhancement on breast MR images: interpretation and imaging pitfalls. Radiographics. 2006 Nov-Dec; 26 (2006 Nov-Dec; 6; 26):1719-34; quiz 1719. [Full Text/Abstract]
Nezafat R, Stuber M, Ouwerkerk R, Gharib AM, Desai MY, Pettigrew RI. B1-insensitive T2 preparation for improved coronary magnetic resonance angiography at 3 T. Magn Reson Med. 2006 Apr; 55 (4; 55; 2006 Apr):858-64. [Full Text/Abstract]
Gabr RE, Ouwerkerk R, Bottomley PA. Quantifying in vivo MR spectra with circles. J Magn Reson. 2006 Mar; 179 (2006 Mar; 179; 1):152-63. [Full Text/Abstract]
Naumova AV, Chacko VP, Ouwerkerk R, Stull L, Marbán E, Weiss RG. Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts. Am J Physiol Heart Circ Physiol. 2006 Feb; 290 (2006 Feb; 2; 290):H837-43. [Full Text/Abstract]
Ouwerkerk R, Weiss RG, Bottomley PA. Measuring human cardiac tissue sodium concentrations using surface coils, adiabatic excitation, and twisted projection imaging with minimal T2 losses. J Magn Reson Imaging. 2005 May; 21 (2005 May; 21; 5):546-55. [Full Text/Abstract]
Chen HH, Le Visage C, Qiu B, Du X, Ouwerkerk R, Leong KW, Yang X. MR imaging of biodegradable polymeric microparticles: a potential method of monitoring local drug delivery. Magn Reson Med. 2005 Mar; 53 (2005 Mar; 3; 53):614-20. [Full Text/Abstract]
Jacobs MA, Barker PB, Argani P, Ouwerkerk R, Bhujwalla ZM, Bluemke DA. Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study. J Magn Reson Imaging. 2005 Jan; 21 (2005 Jan; 21; 1):23-8. [Full Text/Abstract]
Jacobs MA, Ouwerkerk R, Wolff AC, Stearns V, Bottomley PA, Barker PB, Argani P, Khouri N, Davidson NE, Bhujwalla ZM, Bluemke DA. Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications. Technol Cancer Res Treat. 2004 Dec; 3 (6; 3; 2004 Dec):543-50. [Full Text/Abstract]
Ouwerkerk R, Bleich KB, Gillen JS, Pomper MG, Bottomley PA. Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging. Radiology. 2003 May; 227 (2; 2003 May; 227):529-37. [Full Text/Abstract]
Bottomley PA, Ouwerkerk R, Lee RF, Weiss RG. Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med. 2002 May; 47 (2002 May; 5; 47):850-63. [Full Text/Abstract]