U.S. Department of Health and Human Services
Susanne Neumann

 Contact Info

Tel: 301-451-6307
Email: susannen@intra.niddk.nih.gov

 Select Experience

  • Staff ScientistLaboratory of Endocrinology and Receptor Biology, NIDDK, NIH2006–Present
  • Postdoctoral FellowClinical Endocrinology Branch, NIDDK, NIH2002–2006
  • Postdoctoral FellowUniversity of Leipzig, III. Medical Department/Endocrinology and Diabetes Branch2000–2001
  • Ph.D.University of Leipzig, III. Medical Department/Endocrinology and Diabetes Branch2000

 Related Links

  • Cell Biology/Cell Signaling
  • Molecular Biology/Biochemistry
  • Molecular Pharmacology/Toxicology


A selection of recent and significant publications can be viewed below.

Griss J, Jones AR, Sachsenberg T, Walzer M, Gatto L, Hartler J, Thallinger GG, Salek RM, Steinbeck C, Neuhauser N, Cox J, Neumann S, Fan J, Reisinger F, Xu QW, Del Toro N, Pérez-Riverol Y, Ghali F, Bandeira N, Xenarios I, Kohlbacher O, Vizcaíno JA, Hermjakob H. The mzTab Data Exchange Format: Communicating Mass-spectrometry-based Proteomics and Metabolomics Experimental Results to a Wider Audience. Mol Cell Proteomics. 2014 Jun 30; 13 (2014 Jun 30; 13; 10):2765-75. [Full Text/Abstract]
Tacke D, Buchheidt D, Karthaus M, Krause SW, Maschmeyer G, Neumann S, Ostermann H, Penack O, Rieger C, Ruhnke M, Sandherr M, Schweer KE, Ullmann AJ, Cornely OA. Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Ann Hematol. 2014 Sep; 93 (93; 9; 2014 Sep):1449-56. [Full Text/Abstract]
Boutin A, Eliseeva E, Gershengorn MC, Neumann S. β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. FASEB J. 2014 Aug; 28 (28; 8; 2014 Aug):3446-55. [Full Text/Abstract]
Broeckling CD, Afsar Minhas FU, Neumann S, Ben-Hur A, Prenni JE. RAMClust: a novel feature clustering method enables spectral-matching based annotation for metabolomics data. Anal Chem. 2014 Jul 15; 86 (2014 Jul 15; 86; 14):6812-7. [Full Text/Abstract]
Proetel U, Pletsch N, Lauseker M, Müller MC, Hanfstein B, Krause SW, Kalmanti L, Schreiber A, Heim D, Baerlocher GM, Hofmann WK, Lange E, Einsele H, Wernli M, Kremers S, Schlag R, Müller L, Hänel M, Link H, Hertenstein B, Pfirrman M, Hochhaus A, Hasford J, Hehlmann R, Saußele S, German Chronic Myeloid Leukemia Study Group., Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK). Older patients with chronic myeloid leukemia (≥65 years) profit more from higher imatinib doses than younger patients: a subanalysis of the randomized CML-Study IV. Ann Hematol. 2014 Jul; 93 (93; 7; 2014 Jul):1167-76. [Full Text/Abstract]
Ngo MA, Müller A, Li Y, Neumann S, Tian G, Dixon IM, Arora RC, Freed DH. Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts. Mol Cell Biochem. 2014 Jul; 392 (392; 1-2; 2014 Jul):187-204. [Full Text/Abstract]
Neumann S, Burkert K, Kemp R, Rades T, Rod Dunbar P, Hook S. Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunol Cell Biol. 2014 Jul; 92 (6; 92; 2014 Jul):535-42. [Full Text/Abstract]
Brack W, Altenburger R, Schüürmann G, Krauss M, López Herráez D, van Gils J, Slobodnik J, Munthe J, Gawlik BM, van Wezel A, Schriks M, Hollender J, Tollefsen KE, Mekenyan O, Dimitrov S, Bunke D, Cousins I, Posthuma L, van den Brink PJ, López de Alda M, Barceló D, Faust M, Kortenkamp A, Scrimshaw M, Ignatova S, Engelen G, Massmann G, Lemkine G, Teodorovic I, Walz KH, Dulio V, Jonker MT, Jäger F, Chipman K, Falciani F, Liska I, Rooke D, Zhang X, Hollert H, Vrana B, Hilscherova K, Kramer K, Neumann S, Hammerbacher R, Backhaus T, Mack J, Segner H, Escher B, de Aragão Umbuzeiro G. The SOLUTIONS project: challenges and responses for present and future emerging pollutants in land and water resources management. Sci Total Environ. 2014 Jun 17; 503-504 (503-504; 2014 Jun 17):22-31. [Full Text/Abstract]
Neumann S, Hasenauer J, Pollak N, Scheurich P. Dominant Negative Effects of TNF-related Apoptosis-inducing Ligand (TRAIL) Receptor 4 on TRAIL Receptor 1 Signaling by Formation of Heteromeric Complexes. J Biol Chem. 2014 Jun 6; 289 (23; 289; 2014 Jun 6):16576-87. [Full Text/Abstract]
Maschmeyer G, Carratalà J, Buchheidt D, Hamprecht A, Heussel CP, Kahl C, Lorenz J, Neumann S, Rieger C, Ruhnke M, Salwender H, Schmidt-Hieber M, Azoulay E, Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology. Diagnosis and Antimicrobial Therapy of Lung Infiltrates in Febrile Neutropenic Patients (allogeneic SCT excluded) Updated Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Oncol. 2014 May 15; 26 (26; 1; 2014 May 15):21-33. [Full Text/Abstract]
Birkenmeier M, Neumann S, Röder T. Kinetic modeling of riboflavin biosynthesis in Bacillus subtilis under production conditions. Biotechnol Lett. 2014 May; 36 (2014 May; 36; 5):919-28. [Full Text/Abstract]
Hentrich M, Schalk E, Schmidt-Hieber M, Chaberny I, Mousset S, Buchheidt D, Ruhnke M, Penack O, Salwender H, Wolf HH, Christopeit M, Neumann S, Maschmeyer G, Karthaus M, Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology. Central venous catheter-related infections in hematology and oncology: 2012 updated guidelines on diagnosis, management and prevention by the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology. Ann Oncol. 2014 May; 25 (25; 2014 May; 5):936-47. [Full Text/Abstract]
Pyhtila BM, Shaw KA, Neumann SE, Fridovich-Keil JL. Newborn Screening for Galactosemia in the United States: Looking Back, Looking Around, and Looking Ahead. JIMD Rep. [Full Text/Abstract]
Pyhtila BM, Shaw KA, Neumann SE, Fridovich-Keil JL. A brief overview of galactosemia newborn screening in the United States. J Inherit Metab Dis. [Full Text/Abstract]
Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE, ISAC, INSTINCT, SABG, UKCIRG, and Colleagues. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014 Mar; 68 (68; 2014 Mar; 3):242-51. [Full Text/Abstract]
Sur I, Neumann S, Noegel AA. Nesprin-1 role in DNA damage response. Nucleus. 2014 Mar-Apr; 5 (2; 2014 Mar-Apr; 5). [Full Text/Abstract]
Mousset S, Buchheidt D, Heinz W, Ruhnke M, Cornely OA, Egerer G, Krüger W, Link H, Neumann S, Ostermann H, Panse J, Penack O, Rieger C, Schmidt-Hieber M, Silling G, Südhoff T, Ullmann AJ, Wolf HH, Maschmeyer G, Böhme A. Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2014 Jan; 93 (93; 2014 Jan; 1):13-32. [Full Text/Abstract]
Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp. PLoS One. 2014 Mar 25; 9 (2014 Mar 25; 9; 3):e90766. [Full Text/Abstract]
González-Beltrán A, Neumann S, Maguire E, Sansone SA, Rocca-Serra P. The Risa R/Bioconductor package: integrative data analysis from experimental metadata and back again. BMC Bioinformatics. 2014; 15 Suppl 1 (2014; 15 Suppl 1):S11. [Full Text/Abstract]
Neumann S, Noegel AA. Nesprins in cell stability and migration. Adv Exp Med Biol. 2014; 773 (773; 2014):491-504. [Full Text/Abstract]
Schumacher M, Neumann S. [Clinical use of the U-shaped external fixator with enhanced threadplate (UFEG®)]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2014; 42 (2014; 42; 1):5-12. [Full Text/Abstract]
Neumann S, Vladimirov N, Krembel AK, Wingreen NS, Sourjik V. Imprecision of adaptation in Escherichia coli chemotaxis. PLoS One. 2014 Jan 8; 9 (2014 Jan 8; 9; 1):e84904. [Full Text/Abstract]
Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan; 155 (155; 2014 Jan; 1):310-4. [Full Text/Abstract]
Neumann S, Løvdok L, Bentele K, Meisig J, Ullner E, Paldy FS, Sourjik V, Kollmann M. Exponential Signaling Gain at the Receptor Level Enhances Signal-to-Noise Ratio in Bacterial Chemotaxis. PLoS One. 2014 Apr 15; 9 (2014 Apr 15; 4; 9):e87815. [Full Text/Abstract]
Jones MJ, Farré P, McEwen LM, Macisaac JL, Watt K, Neumann SM, Emberly E, Cynader MS, Virji-Babul N, Kobor MS. Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in Down syndrome. BMC Med Genomics. 6 (6):58. [Full Text/Abstract]
Hussain MS, Baig SM, Neumann S, Peche VS, Szczepanski S, Nürnberg G, Tariq M, Jameel M, Khan TN, Fatima A, Malik NA, Ahmad I, Altmüller J, Frommolt P, Thiele H, Höhne W, Yigit G, Wollnik B, Neubauer BA, Nürnberg P, Noegel AA. CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. Hum Mol Genet. 2013 Dec 20; 22 (25; 2013 Dec 20; 22):5199-214. [Full Text/Abstract]
Gershengorn MC, Neumann S. Update in TSH receptor agonists and antagonists. J Clin Endocrinol Metab. 2012 Dec; 97 (2012 Dec; 97; 12):4287-92. [Full Text/Abstract]
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. Thyroid. 2012 Aug; 22 (2012 Aug; 8; 22):839-43. [Full Text/Abstract]
Allen MD, Neumann S, Gershengorn MC. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling. FASEB J. 2011 Oct; 25 (25; 2011 Oct; 10):3687-94. [Full Text/Abstract]
Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence. Thyroid. 2011 Aug; 21 (8; 21; 2011 Aug):907-12. [Full Text/Abstract]
Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb; 96 (2; 2011 Feb; 96):548-54. [Full Text/Abstract]
Neumann S, Huang W, Eliseeva E, Titus S, Thomas CJ, Gershengorn MC. A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Endocrinology. 2010 Jul; 151 (7; 2010 Jul; 151):3454-9. [Full Text/Abstract]
Neumann S, Raaka BM, Gershengorn MC. Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists. Methods Enzymol. 2010; 485 (485; 2010):147-60. [Full Text/Abstract]
Neumann S, Raaka BM, Gershengorn MC. Human TSH receptor ligands as pharmacological probes with potential clinical application. Expert Rev Endocrinol Metab. 2009 Nov 1; 4 (6; 2009 Nov 1; 4):669. [Full Text/Abstract]
Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28; 106 (106; 2009 Jul 28; 30):12471-6. [Full Text/Abstract]
Neumann S, Kleinau G, Costanzi S, Moore S, Jiang JK, Raaka BM, Thomas CJ, Krause G, Gershengorn MC. A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology. 2008 Dec; 149 (2008 Dec; 149; 12):5945-50. [Full Text/Abstract]
Engel S, Skoumbourdis AP, Childress J, Neumann S, Deschamps JR, Thomas CJ, Colson AO, Costanzi S, Gershengorn MC. A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists. J Am Chem Soc. 2008 Apr 16; 130 (130; 15; 2008 Apr 16):5115-23. [Full Text/Abstract]
Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. J Biomol Screen. 2008 Feb; 13 (2; 13; 2008 Feb):120-7. [Full Text/Abstract]
Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC. Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem. 2006 Jun 29; 49 (49; 2006 Jun 29; 13):3888-96. [Full Text/Abstract]
Engel S, Neumann S, Kaur N, Monga V, Jain R, Northup J, Gershengorn MC. Low affinity analogs of thyrotropin-releasing hormone are super-agonists. J Biol Chem. 2006 May 12; 281 (281; 19; 2006 May 12):13103-9. [Full Text/Abstract]
Nwosu BU, Gourgiotis L, Gershengorn MC, Neumann S. A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism. Thyroid. 2006 May; 16 (2006 May; 16; 5):505-12. [Full Text/Abstract]
Jäschke H, Neumann S, Moore S, Thomas CJ, Colson AO, Costanzi S, Kleinau G, Jiang JK, Paschke R, Raaka BM, Krause G, Gershengorn MC. A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). J Biol Chem. 2006 Apr 14; 281 (2006 Apr 14; 281; 15):9841-4. [Full Text/Abstract]
Neumann S, Krause G, Claus M, Paschke R. Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor. Endocrinology. 2005 Jan; 146 (146; 2005 Jan; 1):477-85. [Full Text/Abstract]