U.S. Department of Health and Human Services
Sushil Rane

 Contact Info

Tel: 301-873-4619
Email: ranes@mail.nih.gov

 Select Experience

  • Senior InvestigatorNIDDK, NIH2012–Present
  • InvestigatorNIDDK, NIH2006–2012
  • NCI ScholarNCI, NIH2001–2006
  • FellowBristol-Myers Squibb Pharmaceutical Research Institute1997–1999
  • Ph.D.Temple University School of Medicine1996

 Related Links

  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Stem Cells/Induced Pluripotent Stem Cells


A selection of recent and significant publications can be viewed below.

Kim SY, Lee JH, Merrins MJ, Gavrilova O, Bisteau X, Kaldis P, Satin LS, Rane SG. Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes. J Biol Chem. 2017 Jan 18; 292 (292; 2017 Jan 18; 9):3841-3853. [Full Text/Abstract]
Yadav H, Devalaraja S, Chung ST, Rane SG. TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis. J Biol Chem. 2017 Jan 9; 292 (8; 292; 2017 Jan 9):3420-3432. [Full Text/Abstract]
Wankhade UD, Rane SG. Flow Cytometry Assisted Isolation of Adipose Tissue Derived Stem Cells. Methods Mol Biol. 2017; 1566 (2017; 1566):17-24. [Full Text/Abstract]
Friend DM, Devarakonda K, O'Neal TJ, Skirzewski M, Papazoglou I, Kaplan AR, Liow JS, Guo J, Rane SG, Rubinstein M, Alvarez VA, Hall KD, Kravitz AV. Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. Cell Metab. 2016 Dec 20; 25 (25; 2; 2016 Dec 20):312-321. [Full Text/Abstract]
Tarbell KV, Rane SG. Saving β cell function in the NIK of time. J Exp Med. 2015 Jul 27; 212 (2015 Jul 27; 212; 8):1140-1. [Full Text/Abstract]
Yadav H, Rane SG. Dietary fatty acids: Friends or foes?. Obesity (Silver Spring). 2015 Jul; 23 (2015 Jul; 23; 7):1329. [Full Text/Abstract]
Tiano JP, Springer DA, Rane SG. SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. J Biol Chem. 2015 May 1; 290 (2015 May 1; 18; 290):11431. [Full Text/Abstract]
Fernandez P, Scaffidi P, Markert E, Lee JH, Rane S, Misteli T. Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. Cell Rep. 2014 Oct 1; 9 (2014 Oct 1; 9; 1):248-60. [Full Text/Abstract]
Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes Cancer. 2014 Sep; 5 (9-10; 5; 2014 Sep):306-19. [Full Text/Abstract]
Hall BE, Wankhade UD, Konkel JE, Cherukuri K, Nagineni CN, Flanders KC, Arany PR, Chen W, Rane SG, Kulkarni AB. TGF-β3 knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance. J Biol Chem. 2013 Nov 1; 288 (2013 Nov 1; 288; 44):32074-92. [Full Text/Abstract]
Yadav H, Lee JH, Lloyd J, Walter P, Rane SG. Beneficial metabolic effects of a probiotic via butyrate induced GLP-1 secretion. J Biol Chem. 2013 Aug 30; 288 (35; 288; 2013 Aug 30):25088-97. [Full Text/Abstract]
Yadav H, Rane SG. TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue. Front Endocrinol (Lausanne). 2012; 3 (2012; 3):35. [Full Text/Abstract]
Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 2011 Jul 6; 14 (2011 Jul 6; 14; 1):67-79. [Full Text/Abstract]
Kim SY, Rane SG. The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors. Development. 2011 May; 138 (138; 10; 2011 May):1903-12. [Full Text/Abstract]
Kim YC, Kim SY, Mellado-Gil JM, Yadav H, Neidermyer W, Kamaraju AK, Rane SG. RB regulates pancreas development by stabilizing Pdx1. EMBO J. 2011 Apr 20; 30 (2011 Apr 20; 30; 8):1563-76. [Full Text/Abstract]
Lee JH, Jo J, Hardikar AA, Periwal V, Rane SG. Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass. PLoS One. 2010 Jan 13; 5 (5; 2010 Jan 13; 1):e8653. [Full Text/Abstract]
Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG. Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function. J Biol Chem. 2009 May 1; 284 (2009 May 1; 284; 18):12246-57. [Full Text/Abstract]
Jiao W, Datta J, Lin HM, Dundr M, Rane SG. Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export. J Biol Chem. 2006 Dec 8; 281 (281; 2006 Dec 8; 49):38098-108. [Full Text/Abstract]
Mazumdar M, Lee JH, Sengupta K, Ried T, Rane S, Misteli T. Tumor formation via loss of a molecular motor protein. Curr Biol. 2006 Aug 8; 16 (2006 Aug 8; 16; 15):1559-64. [Full Text/Abstract]
Rane SG, Lee JH, Lin HM. Transforming growth factor-beta pathway: role in pancreas development and pancreatic disease. Cytokine Growth Factor Rev. 2006 Feb-Apr; 17 (2006 Feb-Apr; 17; 1-2):107-19. [Full Text/Abstract]
Reddy HK, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res. 2005 Nov 15; 65 (2005 Nov 15; 22; 65):10174-8. [Full Text/Abstract]
Jiao W, Lin HM, Timmons J, Nagaich AK, Ng SW, Misteli T, Rane SG. E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation. Cancer Res. 2005 May 15; 65 (10; 2005 May 15; 65):4067-77. [Full Text/Abstract]