U.S. Department of Health and Human Services
Wei Yang

 Contact Info

Tel: 301-402-4645
Email: weiy@mail.nih.gov

 Select Experience

  • Ph.D.Columbia University1991
  • M.A.Columbia University1985
  • B.A.State University of New York at Stony Brook1985
  • B.A.State University of New York at Stony Brook1983

 Related Links


Wei Yang, Ph.D., NIH Distinguished Investigator

Section Chief, Mechanism of DNA Repair, Replication, and Recombination SectionLaboratory of Molecular Biology
  • Cancer Biology
  • Chromosome Biology/Epigenetics
  • Molecular Biology/Biochemistry
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Lapkouski M, Tian L, Miller JT, Le Grice SFJ, Yang W. Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation. Nat Struct Mol Biol. 2013 Feb; 20 (20; 2; 2013 Feb):230-6. [Full Text/Abstract]
Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W. Watching DNA polymerase η make a phosphodiester bond. Nature. 2012 Jul 11; 487 (7406; 2012 Jul 11; 487):196-201. [Full Text/Abstract]
Zhao Y, Biertümpfel C, Gregory MT, Hua YJ, Hanaoka F, Yang W. Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A. 2012 May 8; 109 (109; 19; 2012 May 8):7269-74. [Full Text/Abstract]
Gupta S, Gellert M, Yang W. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops. Nat Struct Mol Biol. 2011 Dec 18; 19 (2011 Dec 18; 19; 1):72-8. [Full Text/Abstract]
Yang W. Nucleases: diversity of structure, function and mechanism. Q Rev Biophys. 2011 Feb; 44 (2011 Feb; 44; 1):1-93. [Full Text/Abstract]
Yang W. Topoisomerases and site-specific recombinases: similarities in structure and mechanism. Crit Rev Biochem Mol Biol. 2010 Dec; 45 (6; 2010 Dec; 45):520-34. [Full Text/Abstract]
Biertümpfel C, Zhao Y, Kondo Y, Ramón-Maiques S, Gregory M, Lee JY, Masutani C, Lehmann AR, Hanaoka F, Yang W. Structure and mechanism of human DNA polymerase eta. Nature. 2010 Jun 24; 465 (7301; 465; 2010 Jun 24):1044-8. [Full Text/Abstract]
Wang F, Yang W. Structural insight into translesion synthesis by DNA Pol II. Cell. 2009 Dec 24; 139 (7; 139; 2009 Dec 24):1279-89. [Full Text/Abstract]
Grundy GJ, Ramón-Maiques S, Dimitriadis EK, Kotova S, Biertümpfel C, Heymann JB, Steven AC, Gellert M, Yang W. Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex. Mol Cell. 2009 Jul 31; 35 (2009 Jul 31; 35; 2):217-27. [Full Text/Abstract]
Yang W. An equivalent metal ion in one- and two-metal-ion catalysis. Nat Struct Mol Biol. 2008 Nov; 15 (15; 2008 Nov; 11):1228-31. [Full Text/Abstract]
Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W. Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. EMBO J. 2008 Apr 9; 27 (2008 Apr 9; 7; 27):1172-81. [Full Text/Abstract]
Yang W. Structure and mechanism for DNA lesion recognition. Cell Res. 2008 Jan; 18 (2008 Jan; 1; 18):184-97. [Full Text/Abstract]