U.S. Department of Health and Human Services
William Eaton

 Contact Info

Tel: 301-496-6030
Email: eaton@helix.nih.gov

 Select Experience

  • Scientific DirectorIntramural AIDS Targeted Ant-viral Program (IATAP)1986-Present
  • Ph.D.University of Pennsylvania1967
  • M.D.University of Pennsylvania1964
  • B.A.University of Pennsylvania1959

 Related Links


William A. Eaton, M.D., Ph.D., NIH Distinguished Investigator

Chief, Laboratory of Chemical Physics
Section Chief, Biophysical Chemistry SectionLaboratory of Chemical Physics
  • Biomedical Engineering/Biophysics/Physics


A selection of recent and significant publications can be viewed below.

Cellmer T, Ferrone FA, Eaton WA. Universality of supersaturation in protein-fiber formation. Nat Struct Mol Biol. 2016 Mar 28; 23 (2016 Mar 28; 23; 5):459-61. [Full Text/Abstract]
Chung HS, Piana-Agostinetti S, Shaw DE, Eaton WA. Structural origin of slow diffusion in protein folding. Science. 2015 Sep 25; 349 (6255; 349; 2015 Sep 25):1504-10. [Full Text/Abstract]
Chung HS, McHale K, Louis JM, Eaton WA. Single-molecule fluorescence experiments determine protein folding transition path times. Science. 2012 Feb 24; 335 (335; 6071; 2012 Feb 24):981-4. [Full Text/Abstract]
Chung HS, Gopich IV, McHale K, Cellmer T, Louis JM, Eaton WA. Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein. J Phys Chem A. 2011 Apr 28; 115 (16; 2011 Apr 28; 115):3642-56. [Full Text/Abstract]
Cellmer T, Buscaglia M, Henry ER, Hofrichter J, Eaton WA. Making connections between ultrafast protein folding kinetics and molecular dynamics simulations. Proc Natl Acad Sci U S A. 2011 Apr 12; 108 (108; 2011 Apr 12; 15):6103-8. [Full Text/Abstract]
Chung HS, Louis JM, Eaton WA. Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories. Proc Natl Acad Sci U S A. 2009 Jul 21; 106 (106; 2009 Jul 21; 29):11837-44. [Full Text/Abstract]
Kubelka J, Henry ER, Cellmer T, Hofrichter J, Eaton WA. Chemical, physical, and theoretical kinetics of an ultrafast folding protein. Proc Natl Acad Sci U S A. 2008 Dec 2; 105 (105; 2008 Dec 2; 48):18655-62. [Full Text/Abstract]
Cellmer T, Henry ER, Hofrichter J, Eaton WA. Measuring internal friction of an ultrafast-folding protein. Proc Natl Acad Sci U S A. 2008 Nov 25; 105 (105; 2008 Nov 25; 47):18320-5. [Full Text/Abstract]
Schuler B, Eaton WA. Protein folding studied by single-molecule FRET. Curr Opin Struct Biol. 2008 Feb; 18 (2008 Feb; 1; 18):16-26. [Full Text/Abstract]
Cellmer T, Henry ER, Kubelka J, Hofrichter J, Eaton WA. Relaxation rate for an ultrafast folding protein is independent of chemical denaturant concentration. J Am Chem Soc. 2007 Nov 28; 129 (129; 2007 Nov 28; 47):14564-5. [Full Text/Abstract]
Best RB, Merchant KA, Gopich IV, Schuler B, Bax A, Eaton WA. Effect of flexibility and cis residues in single-molecule FRET studies of polyproline. Proc Natl Acad Sci U S A. 2007 Nov 27; 104 (104; 48; 2007 Nov 27):18964-9. [Full Text/Abstract]
Eaton WA, Henry ER, Hofrichter J, Bettati S, Viappiani C, Mozzarelli A. Evolution of allosteric models for hemoglobin. IUBMB Life. 2007 Aug-Sep; 59 (2007 Aug-Sep; 59; 8-9):586-99. [Full Text/Abstract]
Merchant KA, Best RB, Louis JM, Gopich IV, Eaton WA. Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations. Proc Natl Acad Sci U S A. 2007 Jan 30; 104 (104; 2007 Jan 30; 5):1528-33. [Full Text/Abstract]
Kubelka J, Chiu TK, Davies DR, Eaton WA, Hofrichter J. Sub-microsecond protein folding. J Mol Biol. 2006 Jun 9; 359 (359; 2006 Jun 9; 3):546-53. [Full Text/Abstract]
Christoph GW, Hofrichter J, Eaton WA. Understanding the shape of sickled red cells. Biophys J. 2005 Feb; 88 (2005 Feb; 2; 88):1371-6. [Full Text/Abstract]
Viappiani C, Bettati S, Bruno S, Ronda L, Abbruzzetti S, Mozzarelli A, Eaton WA. New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels. Proc Natl Acad Sci U S A. 2004 Oct 5; 101 (40; 101; 2004 Oct 5):14414-9. [Full Text/Abstract]
Kubelka J, Hofrichter J, Eaton WA. The protein folding 'speed limit'. Curr Opin Struct Biol. 2004 Feb; 14 (2004 Feb; 14; 1):76-88. [Full Text/Abstract]
Lapidus LJ, Eaton WA, Hofrichter J. Measuring dynamic flexibility of the coil state of a helix-forming peptide. J Mol Biol. 2002 May 24; 319 (2002 May 24; 319; 1):19-25. [Full Text/Abstract]
Lapidus LJ, Eaton WA, Hofrichter J. Dynamics of intramolecular contact formation in polypeptides: distance dependence of quenching rates in a room-temperature glass. Phys Rev Lett. 2001 Dec 17; 87 (25; 87; 2001 Dec 17):258101. [Full Text/Abstract]
Eaton WA, Muñoz V, Hagen SJ, Jas GS, Lapidus LJ, Henry ER, Hofrichter J. Fast kinetics and mechanisms in protein folding. Annu Rev Biophys Biomol Struct. 2000; 29 (2000; 29):327-59. [Full Text/Abstract]
Eaton WA. The relationship between coding sequences and function in haemoglobin. Nature. 1980 Mar 13; 284 (5752; 284; 1980 Mar 13):183-5. [Full Text/Abstract]