U.S. Department of Health and Human Services
 

 Contact Info

 
Tel: 602-200-5206
Email: wknowler@phx.niddk.nih.gov
 

 Select Experience

 
  • Chief, Diabetes Epidemiology and Clinical Research SectionNIDDK1979-present
  • Staff Associate/Staff PhysicianNIDDK1975-1979
  • Resident in Preventive MedicineHarvard School of Public Health1974-1975
  • Intern in internal medicineFaulkner and Lemuel Shattuck Hospitals, Boston1973-1974
  • StatisticianSheller-Globe Corporation (chemical manufacturing)1966-1969
  • DrPHHarvard School of Public Health1980
  • MDHarvard Medical School1973
  • MPHHarvard School of Public Health1973
  • BAUniversity of Iowa1968
 

 Related Links

 
Specialties
  • Clinical Research
  • Epidemiology/Population Sciences
  • Genetics/Genomics
  • Social and Behavioral Sciences

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Vijayakumar P, Nelson RG, Hanson RL, Knowler WC, Sinha M. HbA1c and the Prediction of Type 2 Diabetes in Children and Adults. Diabetes Care. 2017 Jan; 40 (40; 2017 Jan; 1):16-21. [Full Text/Abstract]
Vijayakumar P, Wheelock KM, Kobes S, Nelson RG, Hanson RL, Knowler WC, Sinha M. Secular changes in physical growth and obesity among southwestern American Indian children over four decades. Pediatr Obes. 2016 Dec 6; (2016 Dec 6). [Full Text/Abstract]
Hivert MF, Christophi CA, Franks PW, Jablonski KA, Ehrmann DA, Kahn SE, Horton ES, Pollin TI, Mather KJ, Perreault L, Barrett-Connor E, Knowler WC, Florez JC, Diabetes Prevention Program Research Group. Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants. Diabetes. 2016 Feb; 65 (2; 2016 Feb; 65):520-6. [Full Text/Abstract]
Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes. 2016 Jan; 65 (2016 Jan; 65; 1):297-302. [Full Text/Abstract]
Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C. ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes. Diabetes. 2015 Dec; 64 (64; 12; 2015 Dec):4322-32. [Full Text/Abstract]
Iyengar SK, Sedor JR, Freedman BI, Kao WH, Kretzler M, Keller BJ, Abboud HE, Adler SG, Best LG, Bowden DW, Burlock A, Chen YD, Cole SA, Comeau ME, Curtis JM, Divers J, Drechsler C, Duggirala R, Elston RC, Guo X, Huang H, Hoffmann MM, Howard BV, Ipp E, Kimmel PL, Klag MJ, Knowler WC, Kohn OF, Leak TS, Leehey DJ, Li M, Malhotra A, März W, Nair V, Nelson RG, Nicholas SB, O'Brien SJ, Pahl MV, Parekh RS, Pezzolesi MG, Rasooly RS, Rotimi CN, Rotter JI, Schelling JR, Seldin MF, Shah VO, Smiles AM, Smith MW, Taylor KD, Thameem F, Thornley-Brown DP, Truitt BJ, Wanner C, Weil EJ, Winkler CA, Zager PG, Igo RP Jr, Hanson RL, Langefeld CD, Family Investigation of Nephropathy and Diabetes (FIND). Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet. 2015 Aug 25; 11 (8; 2015 Aug 25; 11):e1005352. [Full Text/Abstract]
Look AHEAD Research Group. Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. Diabetologia. 2015 Aug; 58 (8; 58; 2015 Aug):1803-13. [Full Text/Abstract]
Aroda VR, Christophi CA, Edelstein SL, Zhang P, Herman WH, Barrett-Connor E, Delahanty LM, Montez MG, Ackermann RT, Zhuo X, Knowler WC, Ratner RE, Diabetes Prevention Program Research Group. The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up. J Clin Endocrinol Metab. 2015 Apr; 100 (2015 Apr; 100; 4):1646-53. [Full Text/Abstract]
Diabetes Prevention Program Research Group. Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care. 2012 Apr; 35 (35; 4; 2012 Apr):731-7. [Full Text/Abstract]
Berhane AM, Weil EJ, Knowler WC, Nelson RG, Hanson RL. Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death. Clin J Am Soc Nephrol. 2011 Oct; 6 (6; 2011 Oct; 10):2444-51. [Full Text/Abstract]
Williams RC, Muller YL, Hanson RL, Knowler WC, Mason CC, Bian L, Ossowski V, Wiedrich K, Chen YF, Marcovina S, Hahnke J, Nelson RG, Baier LJ, Bogardus C. HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion. Diabetologia. 2011 Jul; 54 (7; 2011 Jul; 54):1684-92. [Full Text/Abstract]
Rubin RR, Ma Y, Peyrot M, Marrero DG, Price DW, Barrett-Connor E, Knowler WC, Diabetes Prevention Program Research Group. Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study. Diabetes Care. 2010 Dec; 33 (33; 2010 Dec; 12):2549-51. [Full Text/Abstract]
Looker HC, Krakoff J, Andre V, Kobus K, Nelson RG, Knowler WC, Hanson RL. Secular trends in treatment and control of type 2 diabetes in an American Indian population: a 30-year longitudinal study. Diabetes Care. 2010 Nov; 33 (2010 Nov; 33; 11):2383-9. [Full Text/Abstract]
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes. 2010 Oct; 59 (2010 Oct; 59; 10):2672-81. [Full Text/Abstract]
Kim NH, Pavkov ME, Knowler WC, Hanson RL, Weil EJ, Curtis JM, Bennett PH, Nelson RG. Predictive value of albuminuria in American Indian youth with or without type 2 diabetes. Pediatrics. 2010 Apr; 125 (4; 2010 Apr; 125):e844-51. [Full Text/Abstract]
Diabetes Prevention Program Research Group., Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, Brown-Friday JO, Goldberg R, Venditti E, Nathan DM. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009 Nov 14; 374 (374; 9702; 2009 Nov 14):1677-86. [Full Text/Abstract]
International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care. 2009 Jul; 32 (32; 7; 2009 Jul):1327-34. [Full Text/Abstract]
Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Abboud HE, Adler SG, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Knowler WC, Kohn OF, Kramp K, Leehey DJ, Nicholas SB, Pahl MV, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS, Family Investigation of Nephropathy and Diabetes Research Group. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008 Oct; 40 (40; 2008 Oct; 10):1185-92. [Full Text/Abstract]
Crandall JP, Knowler WC, Kahn SE, Marrero D, Florez JC, Bray GA, Haffner SM, Hoskin M, Nathan DM, Diabetes Prevention Program Research Group. The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab. 2008 Jul; 4 (7; 4; 2008 Jul):382-93. [Full Text/Abstract]
Rubin RR, Ma Y, Marrero DG, Peyrot M, Barrett-Connor EL, Kahn SE, Haffner SM, Price DW, Knowler WC, Diabetes Prevention Program Research Group. Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care. 2008 Mar; 31 (2008 Mar; 3; 31):420-6. [Full Text/Abstract]
Kim NH, Pavkov ME, Looker HC, Nelson RG, Bennett PH, Hanson RL, Curtis JM, Sievers ML, Knowler WC. Plasma glucose regulation and mortality in pima Indians. Diabetes Care. 2008 Mar; 31 (2008 Mar; 3; 31):488-92. [Full Text/Abstract]
Franks PW, Hanson RL, Knowler WC, Moffett C, Enos G, Infante AM, Krakoff J, Looker HC. Childhood predictors of young-onset type 2 diabetes. Diabetes. 2007 Dec; 56 (56; 2007 Dec; 12):2964-72. [Full Text/Abstract]
Pavkov ME, Knowler WC, Bennett PH, Looker HC, Krakoff J, Nelson RG. Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians. Kidney Int. 2006 Nov; 70 (10; 70; 2006 Nov):1840-6. [Full Text/Abstract]
Kitabchi AE, Temprosa M, Knowler WC, Kahn SE, Fowler SE, Haffner SM, Andres R, Saudek C, Edelstein SL, Arakaki R, Murphy MB, Shamoon H, Diabetes Prevention Program Research Group. Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes. 2005 Aug; 54 (8; 2005 Aug; 54):2404-14. [Full Text/Abstract]
Knowler WC, Hamman RF, Edelstein SL, Barrett-Connor E, Ehrmann DA, Walker EA, Fowler SE, Nathan DM, Kahn SE, Diabetes Prevention Program Research Group. Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes. 2005 Apr; 54 (2005 Apr; 4; 54):1150-6. [Full Text/Abstract]
Pavkov ME, Sievers ML, Knowler WC, Bennett PH, Nelson RG. An explanation for the increase in heart disease mortality rates in diabetic Pima Indians: effect of renal replacement therapy. Diabetes Care. 2004 May; 27 (27; 5; 2004 May):1132-6. [Full Text/Abstract]
Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, Kitzmiller J, Knowler WC, Lebovitz H, Lernmark A, Nathan D, Palmer J, Rizza R, Saudek C, Shaw J, Steffes M, Stern M, Tuomilehto J, Zimmet P, Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003 Nov; 26 (2003 Nov; 26; 11):3160-7. [Full Text/Abstract]
Krakoff J, Funahashi T, Stehouwer CD, Schalkwijk CG, Tanaka S, Matsuzawa Y, Kobes S, Tataranni PA, Hanson RL, Knowler WC, Lindsay RS. Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care. 2003 Jun; 26 (2003 Jun; 6; 26):1745-51. [Full Text/Abstract]
Krakoff J, Lindsay RS, Looker HC, Nelson RG, Hanson RL, Knowler WC. Incidence of retinopathy and nephropathy in youth-onset compared with adult-onset type 2 diabetes. Diabetes Care. 2003 Jan; 26 (2003 Jan; 26; 1):76-81. [Full Text/Abstract]
Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC, Krakoff J. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet. 2002 Jul 6; 360 (2002 Jul 6; 360; 9326):57-8. [Full Text/Abstract]
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 Feb 7; 346 (2002 Feb 7; 6; 346):393-403. [Full Text/Abstract]
Lindsay RS, Kobes S, Knowler WC, Bennett PH, Hanson RL. Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians. Diabetes. 2001 Dec; 50 (2001 Dec; 50; 12):2850-7. [Full Text/Abstract]
Looker HC, Knowler WC, Hanson RL. Changes in BMI and weight before and after the development of type 2 diabetes. Diabetes Care. 2001 Nov; 24 (24; 11; 2001 Nov):1917-22. [Full Text/Abstract]
Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, Roumain J, Bennett PH, Knowler WC. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000 Dec; 49 (49; 12; 2000 Dec):2208-11. [Full Text/Abstract]
Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC. Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes. Diabetes Care. 2000 Aug; 23 (8; 23; 2000 Aug):1113-8. [Full Text/Abstract]
Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC. The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care. 2000 Aug; 23 (8; 23; 2000 Aug):1108-12. [Full Text/Abstract]
Lindsay RS, Dabelea D, Roumain J, Hanson RL, Bennett PH, Knowler WC. Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes. 2000 Mar; 49 (2000 Mar; 49; 3):445-9. [Full Text/Abstract]
Hanson RL, Pratley RE, Bogardus C, Narayan KM, Roumain JM, Imperatore G, Fagot-Campagna A, Pettitt DJ, Bennett PH, Knowler WC. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol. 2000 Jan 15; 151 (2; 151; 2000 Jan 15):190-8. [Full Text/Abstract]
Knowler WC, Sartor G, Melander A, Scherstén B. Glucose tolerance and mortality, including a substudy of tolbutamide treatment. Diabetologia. 1997 Jun; 40 (40; 1997 Jun; 6):680-6. [Full Text/Abstract]
Saad MF, Lillioja S, Nyomba BL, Castillo C, Ferraro R, De Gregorio M, Ravussin E, Knowler WC, Bennett PH, Howard BV. Racial differences in the relation between blood pressure and insulin resistance. N Engl J Med. 1991 Mar 14; 324 (324; 1991 Mar 14; 11):733-9. [Full Text/Abstract]
Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Charles MA, Bennett PH. A two-step model for development of non-insulin-dependent diabetes. Am J Med. 1991 Feb; 90 (1991 Feb; 2; 90):229-35. [Full Text/Abstract]
Knowler WC, Pettitt DJ, Saad MF, Bennett PH. Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Rev. 1990 Feb; 6 (6; 1990 Feb; 1):1-27. [Full Text/Abstract]
Pettitt DJ, Baird HR, Aleck KA, Bennett PH, Knowler WC. Excessive obesity in offspring of Pima Indian women with diabetes during pregnancy. N Engl J Med. 1983 Feb 3; 308 (308; 1983 Feb 3; 5):242-5. [Full Text/Abstract]
Murphy RL Jr, Holford SK, Knowler WC. Visual lung-sound characterization by time-expanded wave-form analysis. N Engl J Med. 1977 Apr 28; 296 (17; 296; 1977 Apr 28):968-71. [Full Text/Abstract]