U.S. Department of Health and Human Services

 Contact Info

Tel: 301-594-3550
Email: seiy@mail.nih.gov

 Select Experience

  • Ph.D.Kurume University School of Medicine, Japan1988
  • M.D.Kurume University School of Medicine, Japan1983

 Related Links


Yoshitasu Sei, M.D., Ph.D.

Staff Scientist, Gastroenterology SectionDigestive Disease Branch
  • Cancer Biology
  • Cell Biology/Cell Signaling
  • Molecular Biology/Biochemistry
  • Stem Cells/Induced Pluripotent Stem Cells
Research Summary/In Plain Language

Research in Plain Language

Our research focuses on studying hormone-producing cells in the intestine.  Hormone-producing cells (enteroendocrine cells) produce hormones by sensing chemicals used to regulate physiological functions in the digestive system.  We use genetically engineered mouse models and a gut model in the culture dish to study how the enteroendocrine cells differentiate from intestinal stem cells to mature hormone producing cells.  Recently, we discovered a group of enteroendocrine cells that express stem cell markers and stay in the stem cell area.  We think this group of enteroendocrine cells may have a unique capability in terms of stemness in certain conditions and that this group of cells may be responsible for the generation of enteroendocrine tumors, including carcinoids.  Studying this group of cells may help scientists discover how endocrine tumors are generated and therefore help them create new drugs to treat these tumors.