The knowledge we gained by studying the structure, function, and regulation of G protein-coupled receptors (GPCRs) should be very useful for the development of drugs with highly improved therapeutic effects and fewer side effects.
My principal research interests are centered on the structure, function, and regulatory mechanisms of GPCRs, especially adenosine receptors and P2Y nucleotide receptors. Allosteric modulation of GPCRs has been my main research project for the past 20 years. A large portion of my recent work focuses on the A3 adenosine receptor, including allosteric modulation and biased agonism. In addition to the traditional GPCR signaling studies, I am also interested in novel signaling pathways, including arrestin GPCR signaling, and in novel concepts such as functional selectivity. I am also interested in using mathematical models to quantify and analyze drug effects and mechanisms. Additionally, I have actively participated in drug discovery and development projects.
Areas in this field that need further study include the structures and the dynamic nature of receptors, the signaling pathways related to receptors and various conditions, the novel roles of receptors, and the novel mechanisms of drug action.