U.S. Department of Health and Human Services

 Contact Info

Tel: 301-402-3776
Email: zhanguog@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH2004–present
  • Visiting FellowNIDDK, NIH2000–2004
  • Assistant ProfessorCenter of Excellence, Beijing Institute of Pharmacology and Toxicology1995–1998
  • Research AssociateCenter of Excellence, Beijing Institute of Pharmacology and Toxicology1993–1995
  • ResidentVeteran Hospital1988–1990
  • Medical StudentMedical College of Weifang1983–1988
  • Ph.D. and Visiting ScientistLeiden University1998–2000
  • M.Sci. and Research AssistantBeijing Institute of Pharmacology and Toxicology1990–1993

 Related Links


    Zhan-Guo Gao, Ph.D.

    Staff Scientist, Molecular Recognition SectionLaboratory of Bioorganic Chemistry
    • Biomedical Engineering/Biophysics/Physics
    • Cancer Biology
    • Immunology
    • Microbiology/Infectious diseases (non-viral)
    • Molecular Pharmacology/Toxicology
    Research Summary/In Plain Language

    Research Summary

    Research Goal

    The knowledge we gained by studying the structure, function, and regulation of G protein-coupled receptors (GPCRs) should be very useful for the development of drugs with highly improved therapeutic effects and fewer side effects.​

    Current Research

    My principal research interests are centered on the structure, function, and regulatory mechanisms of GPCRs, especially adenosine receptors and P2Y nucleotide receptors.  Allosteric modulation of GPCRs has been my main research project for the past 20 years.  A large portion of my recent work focuses on the A3 adenosine receptor, including allosteric modulation and biased agonism.  In addition to the traditional GPCR signaling studies, I am also interested in novel signaling pathways, including arrestin GPCR signaling, and in novel concepts such as functional selectivity.  I am also interested in using mathematical models to quantify and analyze drug effects and mechanisms.  Additionally, I have actively participated in drug discovery and development projects.  

    Applying our Research

    Our basic research can help the public understand the mechanisms of drug actions. It can also provide a basis for other scientists and the industry to develop novel drugs.Our application research may lead directly to the discovery and development of drugs.

    Need for Further Study

    Areas in this field that need further study include the structures and the dynamic nature of receptors, the signaling pathways related to receptors and various conditions, the novel roles of receptors, and the novel mechanisms of drug action.