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NIDDK Newsletter

NIDDK's Health Information News, an e-newsletter that provides subscribers with information from all of the NIDDK's health communications programs, including the National Diabetes Education Program; the National Kidney Disease Education Program; the Weight-control Information Network; health topics for diabetes, digestive diseases, and kidney and urologic diseases; and blood diseases and endocrine and metabolic diseases.

NIDDK News Item

Nov 2, 2016

Today, the Centers for Medicare & Medicaid Services (CMS) finalized the 2017 Physician Fee Schedule final rule that recognizes the importance of primary care by improving payment for chronic care management and behavioral health. The rule also finalizes many of the policies to expand the Diabetes Prevention Program model test to eligible Medicare beneficiaries, the Medicare Diabetes Prevention Program (MDPP) expanded model, starting January 1, 2018.

NIDDK News Item

Nov 1, 2016

For many millions of Americans, diabetes is a lifelong burden. But it does not have to be a lifelong barrier to better health. This National Diabetes Month, the National Institutes of Health encourages people with diabetes and those who care for them to find the support they need, and for all people to gain understanding and offer support to those with this challenging disease.

NIDDK News Item

Oct 27, 2016

National Institutes of Health researchers have identified a novel role for a gene known as heat shock protein 60 (Hsp60), finding that it is critical in tissue regeneration and wound healing. The study found that topical treatment of an Hsp60-containing gel dramatically accelerates wound closure in a diabetic mouse model.

NIDDK News Item

Oct 14, 2016

Analysis of a trial that used the drug canagliflozin found that as people lost weight, their appetite increased proportionately, leading to consumption of more calories and weight loss plateau (leveling off). The findings provide the first measurement in people of how strongly appetite counters weight loss as part of the body’s feedback control system regulating weight. Results are currently available on BioRxiv (link is external) and will publish in Obesity during Obesity Week 2016.

NIDDK News Item

Oct 11, 2016

The National Institutes of Health Nutrition Research Task Force (NRTF) was established to coordinate and accelerate progress in nutrition research across the NIH and guide the development of the first NIH-wide strategic plan for nutrition research for the next 10 years.

NIDDK News Item

Sep 21, 2016

The National Institutes of Health today announced $157 million in awards in fiscal year 2016 to launch a seven-year initiative called Environmental influences on Child Health Outcomes (ECHO).

NIDDK News Item

Sep 19, 2016

Researchers at the National Institutes of Health have discovered a two-way link between depression and gestational diabetes.

NIDDK News Item

Sep 16, 2016

In an effort to make information about clinical trials widely available to the public, the U.S. Department of Health and Human Services today issued a final rule that specifies requirements for registering certain clinical trials and submitting summary results information to ClinicalTrials.gov.

NIDDK Grantee News

Aug 1, 2016

[Medical College of Wisconsin; Case Western Reserve University] Researchers tested whether abnormal autonomic nervous system innervation of the bladder underlies IC (interstitial cystitis)/BPS (bladder pain syndrome) differently than other chronic pelvic pain. Some chronic pelvic pain types showed autonomic neuropathy and some show vagal withdrawal.

NIDDK News Item

Jul 27, 2016

A new drug developed by scientists at the National Institutes of Health limits the progression of liver fibrosis in mice, a hopeful advance against a condition for which there is no current treatment and that often leads to serious liver disease in people with chronic alcoholism and other common diseases.

NIDDK News Item

Jul 11, 2016

A comprehensive investigation of the underlying genetic architecture of type 2 diabetes has unveiled the most detailed look at the genetic differences that heighten a person’s risk for disease development.

NIDDK Grantee News

Jul 11, 2016

[Oregon Health and Science University; University of Pennsylvania School of Medicine] Human pancreatic islets of Langerhans contain five distinct endocrine cell types, each producing a characteristic hormone. The dysfunction or loss of the insulin-producing β cells causes diabetes mellitus, a disease that harms millions. Until now, β cells were generally regarded as a single, homogenous cell population.

NIDDK Grantee News

Jun 15, 2016

[New York University Langone Medical Center] The intestinal “microbiota,” that is, the community of microbes inhabiting the human intestinal tract, undergoes many changes during the first 2 years of life. Bokulich et al. now show that this pattern of development is altered in children who are delivered by cesarean section, fed formula, or treated with antibiotics, compared to those babies who were born vaginally, breast-fed, or unexposed to antibiotics.

NIDDK News Item

Jun 10, 2016

The AMP Type 2 Diabetes Knowledge Portal online library and discovery engine has greatly expanded data and search capabilities to accelerate the pace of scientific advancement.

NIDDK Grantee News

Jun 8, 2016

[Yale University School of Medicine] Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae.

NIDDK Grantee News

Jun 7, 2016

[Colorado School of Public Health; University of Colorado School of Medicine] Poor maternal diet in pregnancy can influence fetal growth and development. We tested the hypothesis that poor maternal diet quality during pregnancy would increase neonatal adiposity (percent fat mass [%FM]) at birth by increasing the FM component of neonatal body composition.

NIDDK Grantee News

Jun 7, 2016

[The Broad Institute of MIT and Harvard; Monash University] Although numerous polymorphisms have been associated with inflammatory bowel disease (IBD), identifying the function of these genetic factors has proved challenging. Here we identified a role for nine genes in IBD susceptibility loci in antibacterial autophagy and characterized a role for one of these genes, GPR65, in maintaining lysosome function.

NIDDK Grantee News

Jun 7, 2016

[University of California San Diego] p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored.

NIDDK Grantee News

Jun 1, 2016

[Nationwide Children’s Hospital; University of New South Wales; Medical College of Wisconsin] Pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are poorly understood. Kumar et al examined a multinational cross-sectional study of children for risk factors, abdominal pain, and disease burden associated with ARP and CP in childhood.

NIDDK Grantee News

May 27, 2016

[California Institute of Technology] Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely undescribed. The human commensal Bacteroides fragilis delivers immunomodulatory molecules to immune cells via secretion of outer membrane vesicles (OMVs).

NIDDK Newsletter

Features information about newly available datasets and materials from NIDDK-funded studies.

NIDDK Grantee News

May 23, 2016

[Vanderbilt University Medical Center] Basement membranes are defining features of the cellular microenvironment; however, little is known regarding their assembly outside cells. We report that extracellular Cl− ions signal the assembly of collagen IV networks outside cells by triggering a conformational switch within collagen IV noncollagenous 1 (NC1) domains.

NIDDK Grantee News

May 10, 2016

[Washington University School of Medicine; Harvard University; Case Western Reserve University School of Medicine] We recently reported the scalable in vitro production of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 diabetic patients (T1D). β-cells are destroyed during T1D disease progression, making it difficult to extensively study them in the past.

NIDDK Grantee News

May 2, 2016

[National Institute of Diabetes and Digestive and Kidney Diseases] Researchers measured long-term changes in resting metabolic rate (RMR) and body composition in participants of “The Biggest Loser” competition. Body composition was measured by dual energy X-ray absorptiometry, and RMR was determined by indirect calorimetry at baseline, at the end of the 30-week competition and 6 years later.

NIDDK Grantee News

Apr 28, 2016

[University of California San Francisco] Haematopoietic stem cells (HSCs) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the mechanism(s) by which inflammatory insults are communicated to HSCs and their consequences for HSC activity remain largely unknown.

NIDDK Grantee News

Apr 27, 2016

[National Institute of Diabetes and Digestive and Kidney Diseases; University of Murcia, Murcia, Spain] The zona pellucida, a matrix that surrounds ovulated eggs, is the site of sperm recognition and binding, which precede sperm penetration and fertilization. Avella et al. identified a peptide from the zona pellucida called ZP2, which the authors attached to agarose beads to facilitate infertility treatment or, conversely, contraception.

NIDDK Grantee News

Apr 21, 2016

[Baylor College of Medicine] Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin.

NIDDK News Item

Apr 18, 2016

New clinical trial results show that transplantation of pancreatic islets — cell clusters that contain insulin-producing cells—prevents severe, potentially life-threatening drops in blood sugar in people with type 1 diabetes. Researchers found that the treatment was effective for people who experienced episodes of severe hypoglycemia — low blood sugar levels that can lead to seizures, loss of consciousness and death — despite receiving expert care.

NIDDK News Item

Apr 18, 2016

Sticking to a healthy diet in the years after pregnancy may reduce the risk of high blood pressure among women who had pregnancy-related (gestational) diabetes, according to a study by researchers at the National Institutes of Health and other institutions. The study was published in Hypertension.

NIDDK Grantee News

Apr 5, 2016

[University of Texas; Medical University of South Carolina] Acute liver failure (ALF) is a rare syndrome of severe, rapid-onset hepatic dysfunction without prior advanced liver disease that is associated with high morbidity and mortality. Intensive care and liver transplantation provide support and rescue, respectively.

NIDDK Grantee News

Apr 1, 2016

[University of Washington; Indiana University] Ultrasonic propulsion is a new technology using focused ultrasound energy applied transcutaneously to reposition kidney stones. We report what are to our knowledge the findings from the first human investigational trial of ultrasonic propulsion toward the applications of expelling small stones and dislodging large obstructing stones.

NIDDK News Item

Mar 29, 2016

Children with Cushing syndrome may be at higher risk for suicide as well as for depression, anxiety and other mental health conditions long after their disease has been successfully treated, according to a study by researchers at the National Institutes of Health.

NIDDK Newsletter

Features updates on NIH and NIDDK activities, events, NIDDK-specific plans, and trans-NIH issues.