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NIDDK Grantee News

May 17, 2017

[Northwestern University; University of Pittsburgh] Researchers conducted one of the largest, prospective, multicenter studies of psychological outcomes in living liver donors, examining mental well-being, psychological growth, motivations and emotions about their donations. Careful screening may optimize outcomes for potentially vulnerable donors.

NIDDK Grantee News

May 3, 2017

[Texas A&M University Health Science Center] Researchers worked with rat models to demonstrate that renal immune cell infiltration and inflammation cause lymphangiogenesis in hypertension- and aging-associated renal injury.

NIDDK Grantee News

Mar 9, 2017

[Harvard Medical School; University of Osnabrück] Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO). Study results demonstrate how variation in a single cytokine can lead to biased downstream signaling and can thereby cause human disease. Moreover, researchers have defined a distinct treatable form of anemia through mutation identification and functional studies.

NIDDK Grantee News

Feb 28, 2017

[Colorado School of Public Health; Wake Forest School of Medicine] The increased prevalence of type 2 diabetes among children and adolescents has been relatively recent in most populations, beginning in the early- to mid-1990s. Additionally, a long-term increase in type 1 diabetes has been observed both worldwide and in the United States. These recent epidemiologic trends in type 1 and type 2 diabetes diagnosed in young individuals raise the question of whether the pattern of complications differs by diabetes type at similar ages and diabetes duration. Recent studies have reported a higher prevalence of some but not all complications in children and adolescents with type 2 diabetes compared with those with type 1.

NIDDK Grantee News

Feb 23, 2017

[Joslin Diabetes Center and Harvard Medical School; University of Campinas] Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines. Transplantation of both white and brown adipose tissue—brown especially—into mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.

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