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The Adipose Tissue Niche: Role in Health and Diseases

11/29/2016 8:00 AM
11/30/2016 5:00 PM
Yes
No

Program Content

Carol Haft, Ph.D.
Adipocyte Biology Program Director, NIDDK
T: 301-594-7689
 

Meeting Logistics

John Hare, M.S., CMP, CGMP
The Scientific Consulting Group, Inc. 
T: 301-670-4990
E: jhare@scgcorp.com
 
Bethesda
 
National Institutes of Health, Building 38A

Event Details

Background

The National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focusing on the role of the adipose tissue niche in the development, maintenance and remodeling of different adipose tissue depots in healthy individuals, and how the extracellular matrix and cellular components of the niche are modified during the develop of diabetes, in the overfed state, and following other metabolic stressors. Speakers will address basic mechanisms, clinical issues and potential new concepts for treatment.

Plenary talks, selected “hot topic” presentations, and a poster session will provide a forum for interactions among basic adipocyte biologists and physiologists, stem cell biologists, bioengineers, and clinical scientists, as well as both established and new investigators in the field.

Meeting Objectives

The scientific focus of this meeting will be on the following topics:

  • Adipose Tissue Remodeling and Fibrosis
  • Adipose Tissue Support Cells:  Role of Pericytes, Vascular Smooth Muscle Cells, Stem Cells and Other Stromal Cells
  • Depot Specific Extracellular Matrix Components and Mechano-transduction
  • Building Fat for Soft Tissue Reconstruction
  • Building Fat Depots on a Chip

Organizing Committee

Dr. Stephen Farmer
Dr. Carol Haft
Dr. Kevin Healy
Dr. Valarie Horsley

Sponsors

The National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, and the U.S. Department of Health and Human Services

Registration Deadline

November 10, 2016

There is no registration fee to attend. However, registration is required. Seating is limited to the first 170 people registered.​​​​​​​​​​​​​​​​​​​​​​​​​​​

Agenda

Agenda (PDF, 140 KB)

November 29, 2016

   
7:30 a.m. – 8:15 a.m. Registration
(Lister Hill Auditorium, NIH Campus)
   
8:15 a.m. – 8:30 a.m.   Opening Remarks/Meeting Overview
   
8:30 a.m. – 9:15 a.m. Keynote 1: Perivascular Cells, Plasticity and Organ Fibrosis
Benjamin Humphreys, M.D. Ph.D., Washington University
   
9:15 a.m. – 10:00 a.m. Keynote 2: Cells and Viscoelasticity
David J. Mooney, Ph.D., Harvard University
   
10:00 a.m. – 10:30 a.m. Break

Session I:

Adipose Tissue Remodeling and Fibrosis
Moderator: Valerie Horsley

   
10:30 a.m. – 11:00 a.m. Adipogenic Signaling in Scleroderma Fibrosis: Potential Clinical Implications
John Varga, M.D., Northwestern University
   
11:00 a.m. – 11:30 a.m. Adipose Tissue Fibrosis: Progenitors Contribution
Karine Clement, M.D., Ph.D., Institute of Cardio-metabolism and Nutrition, Paris
   
11:30 a.m. – 11:45 a.m. Hot Topic—Ubiquitin Ligase Siah2 in Adipocytes Regulated Obesity-Induced Macrophage Recruitment in Adipose Tissue
Elizabeth Floyd, Ph.D., Pennington Biomedical Research Center
   
11:45 a.m. – 12:15 p.m. Myocardin Related Transcription Factor A Regulates Healthy and Unhealthy Remodeling of White Adipose Tissue
Stephen Farmer, Ph.D., Boston University School of Medicine
   
12:15 p.m. – 12:30 p.m. Poster Blitz #1
Boards #s 3,4,6,10,12,16,20,21,22,23
   
12:30 p.m. – 2:00 p.m. Poster Session and Lunch in Atrium

Session II:

Adipose Tissue Support Cells: Role of Pericytes, Vascular Smooth Muscle Cells, Stem Cells and Other Stromal Cells
Moderator: Stephen Farmer

   
2:00 p.m. – 2:30 p.m. Contribution of Mural Cells to Adipose Tissue Remodeling
Rana Gupta, Ph.D., UT Southwestern University
   
2:30 p.m. – 3:00 p.m. Nutrient-Sensing Signaling Mechanisms that Control Adipocyte Expansion and Function
David Guertin, Ph.D., University of Massachusetts Medical School, Worcester
   
3:00 p.m. – 3:15 p.m. Hot Topic—Adipose Tissue Macrophages and Preadipocytes as Mediators and Predictors of Adipose Tissue Remodeling with Weight Loss
Carey Lumeng, M.D., Ph.D., University of Michigan Medical School
   
3:15 p.m. – 3:45 p.m. Mature Adipocytes Contribute to Skin Wound Healing
Valerie Horsley, Ph.D., Yale University
   
3:45 p.m. – 4:15 p.m. Break
   
4:15 p.m. – 4:45 p.m. Transcellular and Inter-Organ Trafficking of Adipose Tissue-Derived Particles
Clair Crewe, Ph.D., UT Southwestern University
   
4:45 p.m. – 5:00 p.m. Hot Topic—Trans-endothelial and Adipocyte Transport of Fatty Acids in White Adipose Tissue is Regulated by Prohibitin/Annexin 2 Interactions
Alexes Daquinag,Ph.D., University of Texas Health Science Center, Houston
   
5:00 p.m. – 5:15 p.m. Hot Topic—Transcription Factor Dynamics Define a Circadian Code for Fat Cell Differentiation
Mary Teruel, Ph.D.,Stanford University
   
5:30 p.m. Adjourn
   

November 30, 2016

   
7:30 a.m. – 8:00 a.m. Registration
(Lister Hill Auditorium, NIH Campus)

Session III:

Depot Specific Extracellular Matrix Components and Mechano-transduction
Moderator: Kevin Healy

   
8:00 a.m. – 8:30 a.m. Extracellular Matrix Control of Adipocyte Progenitor Differentiation and Fibrosis
Matthew Layne, Ph.D., Boston University School of Medicine
   
8:30 a.m. – 9:00 a.m. Heat and Tension in the Adipose Niche
Andreas Stahl, Ph.D., University of California, Berkeley
   
9:00 a.m. – 9:15 a.m. Hot Topic—A Glucocorticoid and Diet-Responsive Signal in the Adipose Niche Cates the Initiation of Adipogenesis
Brian Feldman, M.D, Ph.D., Stanford University School of Medicine
   
9:15 a.m. – 9:45 a.m. Pericellular Collagenolysis and the Regulation of the Adipocyte Transcriptome
Stephen Weiss, M.D., University of Michigan
   
9:45 a.m. – 10:15 a.m. Break

Session IV:

Building Fat for Soft Tissue Reconstruction
Moderator: Bruce Bunnell

   
10:15 a.m. – 10:45 a.m. Tissue Engineered Humanized “Fat on a Chip” Utilizing Adipose Tissue-Derived Stromal Vascular Fraction
Trivia Frazier, Ph.D., Tulane University and LaCell, LLC., New Orleans
   
10:45 a.m. – 11:15 a.m. Adipose Derived Stromal Cells for Soft and Hard Tissues: Perspective of a Cranial Facial Surgeon
Michael Longaker, M.D., Stanford University School of Medicine
   
11:15 a.m. – 11:45 p.m. Our hASC History: Tissue Engineering, Donor-to-Donor Differences, and Translating Textiles to Tissues
Elizabeth Loboa, Ph.D., University of Missouri
   
11:45 p.m. – 12:00 p.m. Hot Topic—Imaging Adipose Tissue Across Scales of Resolution from Two-Photon to Super-Resolution Microscopy
Daniela Malide, M.D., Ph.D., National Institute of Heart, Lung and Blood, NIH
   
12:00 p.m. – 12:15 p.m. Poster Blitz #2
Boards #s 24,28,29,32,34,35,37,38,40,45
   
12:15 p.m. – 1:30 p.m. Poster Session and Lunch

Session V:

Building Fat Depots on a Chip
Moderator: Andreas Stahl

   
1:30 p.m. – 2:00 p.m. Vascularizing Fat on a Chip
Leah Bellas, Ph.D., Boston University
   
2:00 p.m. – 2:30 p.m. Microengineered Physiological Biomimicry: Human Organs-on-a-Chips
Daniel Huh, Ph.D., University of Pennsylvania
   
2:30 p.m. – 2:45 p.m. Hot Topic—A Complex Co-culture White Adipose Tissue Model for Predicting Therapeutic Responses
Rosalyn Abbott, Ph.D., Tufts University
   
2:45 p.m. – 3:15 p.m. Bone Marrow Adipose: Tissue Engineered and in vivo Models
Michaela Reagan, Ph.D., Maine Medical Center Research Institute
   
3:15 p.m. – 3:45 p.m. WAT-on-a-Chip: A Physiologically Relevant Microfluidic System Incorporating White Adipose Tissue
Kevin Healy, Ph.D., University of California, Berkeley
   
3:45 p.m. – 4:00 p.m. Closing Remarks
   
4:00 p.m. Adjournment

Directions/Travel

Travel Arrangements

Participants are responsible for making their own travel arrangements. If you decide to extend your stay to take advantage of lower fares, DC-area attractions are only a short stop away from the suggested hotel.

Hotel and travel information are listed below.

Hotel Reservations

The following hotels provide lodging in relatively close proximity that is accessible by taxi.

Bethesda Marriott Hotel
5151 Pooks Hill Road 
Bethesda, MD  20814 
Phone: 301-897-9400 or 1-800-228-9290
Distance to NIH Campus: 1.4 mi.
 
Bethesda North Marriott Hotel & Conference Center
5701 Marinelli Road 
North Bethesda, MD  20852 
Phone: 301-822-9200 or 1-800-228-9290 
Distance to NIH Campus: 3.6 mi.
 
Hilton Executive Conference Center
1750 Rockville Pike 
Rockville, MD  20852 
Phone: 301-468-1100 or 1-800-HILTONS
Distance to NIH Campus: 4.7 mi.
 
Hyatt Regency Bethesda
One Bethesda Metro Center 
Bethesda, MD  20814 
Phone: 301-657-1234 or 1-800-633-7313 
Distance to NIH Campus: 1.2 mi.

DoubleTree Hotel
8120 Wisconsin Avenue 
Bethesda, MD  20814
Phone: 301-652-2000 or 1-800-222-TREE
Distance to NIH Campus: 0.5 mi.

American Inn of Bethesda
8130 Wisconsin Avenue 
Bethesda, MD  20814 
Phone: 301-656-9300 or 1-800-232-7081 
Distance to NIH Campus: 0.5 mi.

Residence Inn
7335 Wisconsin Avenue 
Bethesda, MD  20814
Phone: 301-718-0200 or 1-800-228-9290
Distance to NIH Campus: 1.2 mi.

Hilton Garden Inn
7301 Waverly Street
Bethesda, MD  20814
Phone: 301-654-8111
Distance to NIH Campus: 1.3 mi.

NIH Visitor Information 

Information on visiting the NIH, campus maps, shuttle schedules, driving directions, security, and more can be found on the NIH Visitor Information page.​​

Minutes

Minutes are currently unavailable.

Attendees

Confirmed Speakers

Keynote
David J. Mooney, Harvard University
Benjamin D. Humphreys, Washington University

Adipose Tissue Remodeling and Fibrosis
Karine Clement, Institute of Cardiometabolism and Nutrition
Stephen Farmer, Boston University School of Medicine
John Varga, Northwestern University

Adipose Tissue Support Cells: Role of Pericytes, Vascular Smooth Muscle Cells, Stem Cells and other Stromal Cells
David Guertin, University of Massachusetts Medical School, Worcester
Rana Gupta, UT Southwestern University
Valerie Horsley, Yale University
Michaela Reagan, Maine Medical Center Research Institute

Depot Specific Extracellular Matrix Components and Mechano-transduction
Christopher Chen, Boston University
Matthew Layne, Boston University School of Medicine
Andreas Stahl, University of California, Berkeley
Steve Weiss, University of Michigan

Building Fat for Soft Tissue Reconstruction
Trivia Frazier, Dillard University
Elizabeth Loboa, University of Missouri
Michael Longaker, Stanford University School of Medicine

Building Fat Depots on a Chip
Evangelia Bellas, Boston University
Kevin Healy, University of California, Berkeley
Daniel Huh, University of Pennsylvania​​​

Abstracts

Meeting participants are encouraged to submit abstracts of their research activities from which posters and “hot topic” oral presentations will be selected. A limited number of travel awards are available for students, post-doctoral fellows and junior investigators submitting abstracts.

Submission Deadline

October 19, 2016

Submitting Abstracts

Please follow the instructions below to submit an abstract for consideration:

  1. Please send the abstract via email to Ms. Heidi Otradovec at otradovech@mail.nih.gov with "Adipose Niche" in the subject line. Attach the abstract as a MS Word document, and make any relevant comments in the text of the email.
  2. The abstract title should be typed in bold font, Title Case Letters (i.e. first letter of each main word capitalized).
  3. List the names, degrees and institutional affiliations of all authors, and underline the name of the presenting author.
  4. Do not leave spaces between the title and the body of the abstract, or between paragraphs and use 1” margins.
  5. The abstract should not exceed one page. Please list the source(s) of funding at the end of the abstract.
  6. Simple tables or graphs may be included; however, they must fit within the designated abstract space.
  7. Please use a common font such as Helvetica, Times New Roman, or Arial.
  8. Save the abstract file as: primary authors’ last name_first word in the title (e.g., Smith_Adrenergic).
 ​Poster Presentations

Posters do not need to be elaborate. Poster boards, (4 feet high by 6 feet wide), pushpins and Velcro will be provided on site. Sponsorship of any type should be indicated on poster.

All presenters must pre-register for the conference.

Location

Line
  • Lister Hill Auditorium
  • MD 20892
Webinar

Contacts

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Program Content

Carol Haft, Ph.D.
Adipocyte Biology Program Director, NIDDK
T: 301-594-7689
 

Meeting Logistics

John Hare, M.S., CMP, CGMP
The Scientific Consulting Group, Inc. 
T: 301-670-4990
E: jhare@scgcorp.com