U.S. Department of Health and Human Services
Remodeling the Hematopoietic Bone Marrow Niche

Remodeling the Hematopoietic Bone Marrow Niche

4/3/2017 12:00 PM
4/3/2017 5:00 PM

Program Content

Cindy N. Roy, Ph.D.
Program Director, Hematology
T: 301-594-8805
E: cindy.roy@nih.gov

Terry Rogers Bishop, Ph.D.
Program Director, Hematology
T: 301-594-7726
E: terry.bishop@nih.gov

Meeting Logistics

Rachel Pisarski
The Scientific Consulting Group, Inc.
T: 301-670-4990
E: rpisarski@scgcorp.com
Natcher Conference Center

Event Details


The hematopoietic niche is a solid organ that serves at least two functions: (1) provision of a nurturing environment for long-term maintenance of quiescent hematopoietic stem cells (HSC) and (2) promotion of HSC differentiation via cell-to-cell interactions and local production of growth-promoting cytokines. The goal of this workshop is to learn more about the structure of the bone marrow, particularly the components of the niche that give rise to circulating blood cells and how the niche remodels to adequately respond to changes in environmental cues. Understanding the capacity of the niche to respond may lead to therapeutic interventions to help a patient rapidly return to homeostatic hematopoiesis after a traumatic insult. We also expect to gain a specific understanding of the current scientific and technologic barriers facing the research community in the pursuit of knowledge in this area. The workshop will provide an opportunity for the research community to cooperatively consider the essential next steps for the field.

Registration Deadline

March 29, 2017



Untitled Document

April 3, 2017

7:30 a.m. Welcoming Remarks
Robert Star, Division of Kidney, Urologic, and Hematologic Diseases,
National Institute of Diabetes and Digestive and Kidney Diseases
7:45 a.m. NIDDK Hematology Program
Terry Bishop, National Institute of Diabetes and Digestive and Kidney Diseases
8:00 a.m. Introduction
Paul Frenette, Albert Einstein College of Medicine
8:30 a.m. Structure-Function of the Niche
David Scadden, Massachusetts General Hospital
9:00 a.m. The Niche during Development
Emmanuelle Passegue, Columbia University
9:30 a.m. BREAK
9:45 a.m. Lineage Instructive Differentiation Signals
João Pereira, Yale University School of Medicine
10:15 a.m. Modeling and Remodeling the Hematopoietic Stem Cell Niche in Zebrafish
Owen Tamplin, University of Illinois at Chicago
10:45 a.m. Healthy and Malignant Hematopoiesis in the Bone Marrow: Dynamic Cells in an Evolving Environment
Cristina Lo Celso, Imperial College of London
1:15 p.m. Blood Flow Makes Blood Grow: Biomechanical Force in Hematopoiesis
Pamela Wenzel, The University of Texas Health Science Center at Houston
1:45 p.m. Marrow Cells Mechanosense Rigidity: From Matrix and Nuclei to Phagocytosis
Dennis Discher, University of Pennsylvania
2:15 p.m. An Engineering Approach to Investigate Niche Regulation of Hematopoietic Stem Cells
Brendan Harley, University of Illinois at Urbana-Champaign
2:45 p.m. Supporting the Niche: 3D Models of Tissue Remodeling
Jeroen Eyckmans, Boston University/Wyss Institute for Biologically Inspired Engineering
3:15 p.m. Identifying Gaps in Knowledge
Moderator: Terry Bishop
Audience Participation


Hotel Accommodations

Hyatt Regency Bethesda Hotel
One Bethesda Metro Center
7400 Wisconsin Avenue
Bethesda, MD 20814
Phone: (301) 657-1234 or (888) 421-1442
Fax: (301) 657-6453

Website: http://www.hyattregencybethesda.com
(More hotel information can be obtained from this website.)

Government Room Rate

A limited block of sleeping rooms for meeting participants has been reserved at the Hyatt Regency Bethesda. The rate is the prevailing government rate of $242 per night for single occupancy, plus tax (13%). To reserve a hotel room at the group rate, call reservations at (888) 421-1442 and identify yourself as a member of the Remodeling the Hematopoietic Bone Marrow Niche Meeting, or click on this link to book your room. The room block will be in effect at the Government rate only until Friday, March 10, 2017, or until full, whichever comes first. Any room reservations received after this date will be accepted on a space- and rate-availability basis.

Reservation Dates

Book arrival on Sunday, April 2, 2017, and departure on Monday, April 3, 2017. If you require alternate dates, please contact Rachel Pisarski of The Scientific Consulting Group, Inc. (SCG). Any alternate date requests will need to be approved through the NIDDK.


Please be certain that the hotel provides you with a confirmation number for your reservation. After March 10, 2017, the official room block will be released, and the hotel may charge significantly higher rates or may be sold out. When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 4:00 p.m., and checkout time is 12:00 p.m.


If you need to cancel your reservation, please do so by 4:00 p.m. on the day prior to arrival, or you will be charged a no-show fee for 1 night on your credit card.

NIH Visitor Information

NIH campus maps, shuttle schedules, driving directions, security, and other information about visiting the NIH can be found on the NIH Visitor Information page. ​


Minutes are currently unavailable.


Attendees are currently unavailable.


Submission Deadline

Extended Submission Deadline: Monday, March 13, 2017
Notification of Acceptance: Monday, March 20, 2017

Submitting Abstracts

All abstracts must be submitted via email to Rachel Pisarski of The Scientific Consulting Group, Inc. at rpisarski@scgcorp.com with “Remodeling the Bone Marrow Abstract” in the subject line. The body of the email should identify the submitting author and the career development stage of the submitting author: student, fellow, instructor, assistant professor, scientist, etc.

Selected abstracts will be presented in poster form.

Please note that submissions for travel awards closed with the original abstract deadline of March 6, 2017.

Junior-level participants (students, fellows, instructors, and assistant professors) with the highest-scoring abstracts will be eligible for a modest travel award.

Travel award notifications will be made by March 20, 2017.

Formatting Requirements

  1. A completed poster abstract should include a statement of purpose, methods used, and a summary of results in sufficient detail to support the conclusion. Statements such as “results will be described” should be avoided.
  2. The poster abstract should fit on half of an 8.5" × 11" page. Abstracts should be no more than 250 words (not including title, names and affiliations).
  3. The abstract should be typed single-spaced using 12-point Times New Roman font.
  4. The title should be boldface and followed by one return.
  5. Both the authors list (authors' first and last names, degrees) and the list of affiliations/institutions (including city, state, and country) should be followed by one return. The name of the presenting author should be underlined. Provide any grant acknowledgments for your research (e.g., R01-DK13028) at the end of your abstract.
  6. The abstract file name should be: presenting author’s Last name_First word in the title (e.g., Zucker_Effects).

Poster Presentations

Selected poster abstracts will appear in the meeting materials. Each author is allotted a 4-foot-high by 6-foot-wide posterboard. The poster session will be held Monday, April 3, during the lunch break.

If your abstract is selected for a poster presentation, please arrive between 7:00 and 7:30 a.m., April 3, 2017, to mount your poster on the posterboard. Pushpins and Velcro will be provided onsite. You will be responsible for removing and shipping your poster at the end of the meeting. Any remaining posters will be discarded.

If you have any questions about the scientific content of the workshop, please contact Dr. Terry Bishop (terry.bishop@nih.gov) or Dr. Cindy Roy (cindy.roy@nih.gov). For questions/concerns about workshop logistics, please contact Ms. Rachel Pisarski (rpisarski@scgcorp.com). We look forward to meeting and working with you. We anticipate a stimulating and productive workshop.

Photography Guidelines

Photography is not allowed where posters are displayed.


  • National Institutes of Health
  • Building 45
  • MD 20894



Program Content

Cindy N. Roy, Ph.D.
Program Director, Hematology
T: 301-594-8805
E: cindy.roy@nih.gov

Terry Rogers Bishop, Ph.D.
Program Director, Hematology
T: 301-594-7726
E: terry.bishop@nih.gov

Meeting Logistics

Rachel Pisarski
The Scientific Consulting Group, Inc.
T: 301-670-4990
E: rpisarski@scgcorp.com