U.S. Department of Health and Human Services
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Workshop: Role of Macrophages in Blood Cell Development

2/20/2015 8:00 AM
2/20/2015 5:00 PM
No
No
​​
Bethesda
 
National Institutes of Health

Event Details

Meeting Focus:

Scientific observations support the hypothesis that macrophages regulate critical stages of the development, terminal differentiation, and death (or recycling) of erythrocytes. However the molecular interactions that occur between erythroid progenitors or erythrocytes and macrophages—and the biochemical pathways that govern those interactions—are incompletely understood. This workshop aims to review the most recent progress in the field and to promote discussion of the gaps in our knowledge of these biological processes and pathways. We also hope to gain a specific understanding of the current scientific and technologic barriers to the hematology research community in the pursuit of knowledge in this area.​

Agenda

Ti​me

Speaker

Title

Opening

8:00 – 8:30 a.m.

​Registration

8:30 – 8:45 a.m.

Terry Bishop, Ph.D.
NIDDK, NIH

Welcome, Introduction, and Purpose

8:45 – 9:00 a.m.

Mohandas Narla, D.Sc.
New York Blood Center

Perspective on Macrophages in Erythropoiesis: History and Horizons

Session I: Developmental Origins of Macrophages (Moderator: Terry Bishop)

9:00 – 9:20 a.m.

James Palis, M.D.
University of Rochester

Emergence of HSC-independent Myeloid and Erythroid Potential in the Mammalian Embryo

9:20 – 9:30 a.m.

Discussion

9:30 – 9:50 a.m.

Frederic Geissmann, M.D., Ph.D.
King's College London

Macrophage Lineages: Yolk Sac Versus
Hematopoietic Stem Cells

9:50 – 10:00 a.m.

Discussion

10:00 – 10:20 a.m.

Miriam Merad, M.D., Ph.D.
Mt. Sinai School of Medicine

Regulation of Tissue Macrophage Development
and Function

10:20 – 10:30 a.m.

Discussion

10:30 – 11:00 a.m.

BREAK

Session II: Macrophage-associated Erythropoiesis (Moderator: Manjit Hanspal)

11:00 – 11:20 a.m.

James Bieker, Ph.D.
Mt. Sinai School of Medicine

Role of KLF1 in Erythroid-myeloid Progenitors

11:20 – 11:30 a.m.

Discussion

11:30 – 11:50 a.m.

Beverly Torok-Storb, Ph.D.
Fred Hutchison Cancer Research Center

Controlling Monocyte Fates

11:50 a.m. – 12:00 p.m.

Discussion

12:00 – 12:30 p.m.

LUNCH

12:30 – 1:30 p.m.

POSTER SESSION

Session III: Physical and Chemical Cell-Cell Interactions (Moderator: James Palis)

1:30 – 1:50 p.m.

Elliott Hagedorn, Ph.D.
Boston Children's Hospital

Primitive Macrophages Regulate Definitive Blood Stem Cell Migration during Zebrafish Development

1:50 – 2:00 p.m.

Discussion

2:00 – 2:20 p.m.

Tsvee Lapidot, Ph.D.
Weizmann Institute

Bone Marrow Cell-Cell Communication Regulates Blood Forming Stem Cell Development: The Role of aSMA+ Macrophages and Coagulation

2:20 – 2:30 p.m.

Discussion

2:30 – 2:50 p.m.

David Gosselin, Ph.D.
University of California, San Diego

Environmental Influences on Macrophage Transcriptional Program

2:50 – 3:00 p.m.

Discussion

3:00 – 3:15 p.m.

BREAK

Session IV: Role of Macrophages in Erythroid Survival and Turnover (Moderator: Cindy Roy)

3:15 – 3:35 p.m.

Thalia Papayannopoulou, M.D., D.Sc.
University of Washington

Dissecting the Functional Contribution of Erythroid Cells and Macrophage Subsets to Erythroid Stress Response

3:35 – 3:45 p.m.

Discussion

3:45 – 4:05 p.m.

Robert Paulson, Ph.D.
Pennsylvania State University

Changes in Macrophage Signals Regulate Stress Erythropoiesis

4:05 – 4:15 p.m.

Discussion

Session V: Needs Assessment and Unanswered Questions (Moderator: Nohandas Narla)

4:15 – 5:00 p.m.

All Attendees

Open Forum
Recorders:
Terry Bishop, Ph.D.
Manjit Hanspal, Ph.D.
Cindy Roy, Ph.D.
NIDDK/NHLBI, NIH

5:00 p.m.

Adjournment

 

Directions/Travel

MEETING FACILITY

National Institutes of Health

Natcher Conference Center (Building 45), Rooms E1/E2

9000 Rockville Pike

Bethesda, MD  20892

* Self-parking is available at the Gateway Parking Garage for a maximum of $12 per day.

DIRECTIONS TO NIH CAMPUS

National Institutes of Health

Building 45, Natcher Conference Center

9000 Rockville Pike

Bethesda, MD  20892 

NIH Security:
The NIH, like all Federal Government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors.

Perimeter Security:
The NIH Gateway Center is located adjacent to the Medical Center Metro Station at the South Drive entrance to campus from Rockville Pike/Wisconsin Avenue (Route 355). It combines visitor parking, non-commercial vehicle inspection, and visitor ID processing, all in one location. The NIH will process all visitors in vehicles or as pedestrians.

All visitor vehicles—including taxicabs, hotel and airport shuttles, delivery trucks, and vans—will be inspected before being allowed on campus. Visitors will be asked to show one (1) form of identification (a Government-issued photo ID: driver's license, passport, green card, etc.) and state the purpose of their visit. Be sure to allow at least 15–20 minutes for this vehicle inspection procedure.

Building Security:
Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day. Employees and visitors should continue to wear their identification prominently at all times while on campus. Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns. At building entrances where guards are posted, employees must show an HHS-issued photo ID (e.g., your NIH-issued ID badge).
Visitors may be required to log in, wear a visitor's pass, and be escorted by an employee through the building. Visitors also may be required to pass through a metal detector and have bags, backpacks, or purses inspected or X-rayed as they enter buildings. Security staff will confiscate any suspicious or potentially dangerous materials. U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches. Meeting participants may want to leave extra bags or personal belongings at their hotel to minimize the time needed for inspection.

Weekday Pedestrian Campus Access:
All visitors must enter through the NIH Gateway Center at the Medical Center Metro Station or the West Gateway Center (see the Visitor Map at http://www.ors.od.nih.gov/maps/Pages/NIH-Visitor-Map.aspx).

Gateway Center
Wisconsin Avenue at Gateway Drive (near the Metro)
Open 24 hours, 7 days per week

West Gateway Center
Near Old Georgetown Road and South Drive
Open 6:00 a.m. – 12:00 p.m., Monday–Friday

DRIVING DIRECTIONS TO NIH

From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for
9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South (which changes its name to Wisconsin Avenue) and stay in the right lane. Travel approximately 1 mile and follow signs to the Main Visitor's entrance (Gateway Drive), which will be on the right just past the traffic light at South Drive.

From Points North and West:

Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow the signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Travel approximately 1 mile and follow the signs to the Main Visitor's entrance (Gateway Drive), which will be on the right just past the traffic light at South Drive.

From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tysons Corner/Rockville. Follow I-495 for
20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and follow the signs to the Main Visitor's entrance (Gateway Drive), which will be on the right just past the traffic light at South Drive.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take Route 195 to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow the signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and follow the signs to the Main Visitor's entrance (Gateway Drive), which will be on the right just past the traffic light at South Drive.

From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles. Stay to the right on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore to proceed toward Bethesda (I-495). Continue approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355). Travel approximately 1 mile and follow the signs to the Main Visitor's entrance (Gateway Drive), which will be on the right just past the traffic light at South Drive.

From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway). Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and follow signs to the Main Visitor's entrance (Gateway Drive), which will be on the right just past the traffic light at South Drive.

HOTEL ACCOMMODATIONS

Hyatt Regency Bethesda (directly above Metro)
One Bethesda Metro Center
Wisconsin Avenue at Old Georgetown Road
Bethesda, MD
(301) 657-1234, 1-800-233-1234

Bethesda Marriott
5151 Pooks Hill Road
Bethesda, MD
(301) 897-9400

Doubletree Hotel Bethesda
8120 Wisconsin Avenue
Bethesda, MD
(301) 652-2000

American Inn of Bethesda
8130 Wisconsin Avenue
Bethesda, MD
(301) 656-9300, 1-800-323-7081

Bethesda Court Hotel
7740 Wisconsin Avenue
Bethesda, MD
(301) 656-2100, 1-800-874-0050

Marriott Residence Inn
7335 Wisconsin Avenue
Bethesda, MD
(301) 718-0200, 1-800-331-3131​

Minutes

​Meeting minutes are not available at this time.

Attendees

​Atte​ndee information is not available at this time.

Abstracts

​​All workshop participants who would like to bring a poster presentation to the Role of Macrophages in the Blood Cell Development Workshop should submit a concise 1-page abstract summarizing their presentation no later than Monday, February 9, 2015. Trainees with the highest scoring abstracts will be eligible for a modest travel award.
 
Please follow the instructions below to submit a poster abstract for consideration.
  • The abstract must not exceed 1 page of text using 11-point type, single-spaced.
  • The abstract text is limited to 500 words.
  • The poster abstract should include a title, all authors (presenting author should be clearly underlined), department affiliation, university, city, state/province, country, and email address.
  • Please acknowledge appropriate funding sources for your research.
  • Submit your abstract in electronic format, preferably MS Word.
  • Email the poster abstract no later than Monday, February 9, 2015, to Ms. Mary Allen at mallen@scgcorp.com.

Location

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  • Natcher Conference Center (Building 45), Rooms E1/E2
  • 9000 Rockville Pike
  • MD 20892
Webinar

Contacts

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