U.S. Department of Health and Human Services

Biliary Atresia: A Clinical and Translational Science Research Workshop

6/28/2017 7:00 AM
6/28/2017 7:00 PM

Program Content

Ed Doo, M.D.
Division of Digestive Diseases and Nutrition, NIDDK
T: (301)-451-4524
E: dooe@niddk.nih.gov

Meeting Registration

Lauren Meskill
Division of Digestive Diseases and Nutrition, NIDDK
E: MeskillL@extra.niddk.nih.gov

Lister Hill Center Auditorium

Event Details


Biliary atresia is a rare, but one of the most common severe pediatric liver diseases affecting approximately 1:5000 to 1:18,000 newborns. Recent intervention studies on immune modulation for biliary atresia have not yielded any substantial improvement in altering the liver disease trajectory and associated liver disease related complications. As such, biliary atresia continues to account for approximately 40-50% of pediatric liver transplantations in the United States.

Meeting Objectives

The purpose of this meeting will be to bring together clinical and translational experts in biliary atresia to examine the current state of clinical and translational science that will allow for the identification and prioritization of achievable and feasible research priorities that will further advance the understanding of the clinical pathophysiology of this condition.

Further details regarding the agenda, date and location of this meeting will be forthcoming on this website.

Organizing Committee

Ronald Sokol, M.D., University of Colorado School of Medicine
Rebecca Wells, M.D., University of Pennsylvania School of Medicine
Jorge Bezera, M.D., Cincinnati Children's Hospital Medical Center
Edward Doo, M.D., NIDDK/NIH
Jay Hoofnagle, M.D., NIDDK/NIH

Registration Deadline

June 1, 2017 or until full.​​

RSVP to Lauren Meskill via email with your name, affiliation and phone number​​​​​​.​


June 28, 2017

8:00 a.m. – 8:10 a.m. Welcome and Introduction
Edward Doo and Ronald Sokol

Session I

Clinical Aspects and Genetics of Biliary Atresia (BA)
Moderator: Ronald Sokol

8:10 a.m. – 8:30 a.m. Biliary atresia: A clinical challenge in the 21st Century
Ronald Sokol
8:30 a.m. – 8:50 a.m. Clinical Variants of biliary atresia
Mark Davenport
8:50 a.m. – 9:10 a.m. Genetic Susceptibility and Causation of BA
Nancy Spinner
9:10 a.m. – 9:30 a.m. Prenatal versus Postnatal onset of BA: Implications for pathogenesis
Benjamin Shneider
9:30 a.m. – 9:45 a.m. Discussion
9:45 a.m. – 10:00 a.m. Break and Poster Viewing

Session II

Cholangiocyte Biology, Injury and Fibrosis
Moderator: Rebecca Wells

10:00 a.m. – 10:20 a.m. Embryology and Regulation of Bile Duct Development and BA
Frederick Lemaigre
10:20 a.m. – 10:40 a.m. Genetic Variation in the Proteostatic Stress Response - Potential BA Risk Factor
Michael Pack
10:40 a.m. – 11:00 a.m. Biliatresone: Novel toxic injury to the cholangiocyte
Rebecca Wells
11:00 a.m. – 11:20 a.m. Mechanisms of Fibrosis in Cholangiopathies
Mario Strazzabosco
11:20 a.m. – 11:40 a.m. Discussion
11:40 a.m. – 12:40 p.m. Lunch (on your own) and Poster Viewing

Session III

Inflammation and Fibrosis in Biliary Atresia
Moderator: Jorge Bezerra

12:40 p.m. – 1:00 p.m. Role of Viruses in Biliary Atresia: From mouse models to human data
Claus Petersen
1:00 p.m – 1:20 p.m. Immunologic Effectors of Biliary Atresia: Injury and survival signals
Jorge Bezerra
1:20 p.m. – 1:40 p.m. Autoimmunity in Biliary Atresia
Cara Mack
1:40 p.m. – 2:00 p.m. Liver Fibrosis in Biliary Atresia
Mikko Pakarinen
2:00 p.m.. – 2:20 p.m. Discussion
2:20 p.m. – 2:35 p.m. Break and Poster Viewing and Removal

Session IV

Translating Science into Action
Moderator: Saul Karpen

2:35 p.m.. – 2:55 p.m. Novel Therapeutic Targets and Strategies
Saul Karpen
2:55 p.m – 3:15 p.m. Epigenetic Targets in Obstructive Cholestasis
Frederick Suchy
3:15 p.m. – 3:35 p.m. Biliary Organoids to Model Biliary Diseases
Ludovic Vallier
3:35 p.m. – 3:55 p.m. Cell based therapeutics: Is there a role in biliary atresia?
Holger Willenbring
3:55 p.m. – 4:20 p.m. Discussion

Session V

Moderators: Jay Hoofnagle, Ronald Sokol, Rebecca Wells, Jorge Bezerra

4:20 p.m. – 5:00 p.m. Defining research challenges, priorities, and opportunities for biliary atresia
Audience and Moderators


Hotel Accommodations

Bethesda North Marriott Hotel and Conference Center
5701 Marinelli Road
Bethesda, MD 20852

Please be advised that meeting attendees are responsible for your own travel arrangements and costs. We have secured 55 rooms at a rate of $242 plus 13% taxes for meeting attendees so availability is on a first come-first serve basis. The Bethesda area hotels book up quickly during the months of May and June so you may wish to book your lodgings early. You may possibly be able to secure less expensive lodgings through other booking mechanisms (i.e., Expedia) and you are free to book your lodgings at any hotel of your choice.

To reserve a room under the room block at the Bethesda North Marriott, please use this URL: https://aws.passkey.com/e/49021375
Or call: Reservations Toll Free: 1-877-212-5752; Reservations Local Phone: 1-301-822-9200

Reservation Dates

Book arrival on Tuesday, June 27, 2017, and departure on Wednesday, June 28, 2017.​​​


Minutes are currently unavailable.


Attendees are currently unavailable.


Submitting Abstracts

(Students, Postdoctoral Fellows/Junior Faculty Only)

Abstracts should be limited to one page. Include a title, all authors (presenting author should be clearly underlined), departmental affiliation, university, city, state/province, country, zip code/postal code, and email address, along with sufficient experimental detail to assess the relevance of the work. Please acknowledge appropriate funding sources for your research. Inclusion of figures is encouraged.

Please send your abstract to Ed Doo (dooe@niddk.nih.gov).

You will be notified if your abstract has been accepted to present.​​​


  • NIH Building 38A
  • 9000 Rockville Pike
  • MD 20894



Program Content

Ed Doo, M.D.
Division of Digestive Diseases and Nutrition, NIDDK
T: (301)-451-4524
E: dooe@niddk.nih.gov

Meeting Registration

Lauren Meskill
Division of Digestive Diseases and Nutrition, NIDDK
E: MeskillL@extra.niddk.nih.gov