U.S. Department of Health and Human Services

Chronic Pancreatitis in the 21st Century: Research Challenges and Opportunities

7/27/2016 8:00 AM
7/27/2016 5:00 PM
No
No
412-648-8213

Program Content

Dana Andersen, M.D.
Scientific Program Manager
Division of Digestive Diseases and Nutrition, NIDDK
T: 410-868-0638

 

Logistics & Registration

Mary Allen
Conference Planner
The Scientific Consulting Group, Inc.
T: 301-67-4990
Pittsburgh
 
The University Club

Event Details

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Background

Hereditary and acquired chronic pancreatitis are diseases that are rarely diagnosed early in their course. The delayed diagnosis complicates effective therapy, and both forms of chronic pancreatitis (CP) result in severe disability, lifelong metabolic disease, and a high risk of pancreatic cancer. Although recurrent or persistent pain is a hallmark of both forms of CP, it is difficult to quantify and may be absent despite advanced disease. Recent studies suggest that the most effective treatments for hereditary and acquired CP may differ, but the indications for genetic studies in CP patients and their role in defining therapy remain uncertain.

Meeting Objectives

Recent advances in the understanding of the pathophysiology of hereditary and acquired CP provide new insights into the shared and separate mechanisms of these diseases. The role of genetic testing, the evaluation and treatment of pain syndromes, and the possible value of separate treatment algorithms all provide new evidence for improved management of CP. The purpose of the planned workshop is to explore these advances, inform the community of clinician investigators, and identify research gaps that might shape future funding initiatives by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and other agencies.

The 1-day workshop will be open to the public and will be held at the University Club on the campus of the University of Pittsburgh immediately prior to the start of the annual PancreasFest meeting on July 27, 2016. The workshop will consist of a number of invited expert speakers and moderators who will explore topics chosen by a multidisciplinary organizing committee. The NIDDK will authorize an external meeting planning group, The Scientific Consulting Group, Inc. (SCG) of Gaithersburg, Maryland, to assist with the meeting logistics. Plans for the workshop—including topics, speaker selection, design of the workshop sessions, discussion of possible poster presentations, and engagement with other stakeholders—will be the responsibility of the organizing committee.

Organizing Committee

Co-chairs

Dr. Darwin Conwell
The Ohio State University

Dr. Aliye Uc
The University of Iowa

Members

Dr. Dana Andersen
National Institute of Diabetes and Digestive and Kidney Diseases

Dr. Christopher Forsmark
University of Florida

Dr. Mark Lowe
University of Pittsburgh

Dr. Jose Serrano
National Institute of Diabetes and Digestive and Kidney Diseases

Dr. Vikesh Singh
The Johns Hopkins Hospital

Dr. David Whitcomb
University of Pittsburgh​

Registration Deadline

July 20, 2016​​

Agenda

July 27, 2016

   
7:30 a.m. – 8:00 a.m. Registration
   
8:00 a.m. – 8:10 a.m.   Welcome
Aliye Uc and Darwin Conwell, Co-chairs
   
8:10 a.m. – 8:35 a.m.   Introduction and Overview

Chronic Pancreatitis (CP): Lessons Learned, Current Knowledge, and Future Directions
David Whitcomb

Session 1

Pathophysiology of CP
Moderators: Aliye Uc and Mark Lowe

   
8:35 a.m. – 9:00 a.m. Competing Models of CP Pathophysiology
Ashok Saluja
   
9:00 a.m. – 9:25 a.m. Environmental Risk Factors
Dhiraj Yadav
   
9:25 a.m. – 9:50 a.m. Genetic Influences and the Value of Testing
Markus Lerch
   
9:50 a.m. – 10:15 a.m. Fibrosis: Pathophysiology, Prevention, and Reversal
Brent Neuschwander-Tetri
   
10:15 a.m. – 10:30 a.m. Break

Session 2

Exocrine Complications of CP
Moderators: Darwin Conwell and Christopher Forsmark

   
10:30 a.m. – 10:55 a.m. Assessing Acinar and Duct Cell Function: Gaps and Opportunities
Mark Lowe
   
10:55 a.m. – 11:20 a.m. Mechanisms and Biomarkers for Progression from Recurrent Acute Pancreatitis to CP
Name
   
11:20 a.m. – 11:45 a.m. Pancreatic Enzyme Replacement Therapy: Treating Exocrine Pancreatic Insufficiency and Beyond
Christopher Forsmark
   
11:45 a.m. – 12:10 p.m. New Approaches to Restoration of Pancreatic Secretion
Aliye Uc
   
12:10 p.m. – 1:05 p.m. Lunch (Box lunch reservations available on registration website)

Luncheon Lecture: Predisposing Factors and Early Detection of Pancreatic Ductal Adenocarcinoma in CP
Suresh Chari

Session 3

Endocrine Complications of CP
Moderators: Melena Bellin and Dana Andersen

   
1:05 p.m. – 1:30 p.m. Type 3c Diabetes: Diagnosis, Prevention, and Therapy
Melena Bellin
   
1:30 p.m. – 1:55 p.m. Exocrine Effects on Endocrine Cells: Lessons from Cystic Fibrosis-related Diabetes
John Englehardt
   
1:55 p.m. – 2:20 p.m. Exocrine Effects on Endocrine Cells: Protective Effects of Insulin on Acinar Cells During Pancreatitis
Jason Bruce
   
2:20 p.m. – 2:45 p.m. Bone Disease in CP: Prevalence, Prevention, and Therapy
Stephen O’Keefe
   
2:45 p.m. – 3:05 p.m. Break

Session 4

Pain Complications of CP
Moderators: Eva Szigethy and Asbjørn Drewes

   
3:05 p.m. – 3:30 p.m. Pain in CP: Is it All About Central Sensitization?
Asbjørn Drewes
   
3:30 p.m. – 3:55 p.m. Biomarkers of Pain in CP
Jay Pasricha
   
3:55 p.m. – 4:20 p.m. Clinical and Etiologic Factors Affecting Pain Outcomes after Intervention
Vikesh Singh
   
4:20 p.m. – 4:55 p.m. Emerging Therapies to Improve Quality of Life and Manage Pain in CP
Tonya Palermo
   
4:55 p.m. – 5:00 p.m. Group Discussion and Recommendations
Aliye Uc and Darwin Conwell, Moderators
   
5:00 p.m. Adjournment

Directions/Travel

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Minutes

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Attendees

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Abstracts

Abstracts are currently unavailable.

Location

Line
  • 123 University Place
  • PA 15260
Webinar

Contacts

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Program Content

Dana Andersen, M.D.
Scientific Program Manager
Division of Digestive Diseases and Nutrition, NIDDK
T: 410-868-0638

 

Logistics & Registration

Mary Allen
Conference Planner
The Scientific Consulting Group, Inc.
T: 301-67-4990