U.S. Department of Health and Human Services
Functional Bowel Disorders Workshop: Future Research Directions in Pathophysiology, Diagnosis and Treatment

Functional Bowel Disorders Workshop: Future Research Directions in Pathophysiology, Diagnosis and Treatment

6/23/2016 8:00 AM
6/24/2016 12:30 PM
No
No
​​For questions concerning program content, contact

Frank A. Hamilton
Program Director
Division of Digestive Diseases and Nutrition
NIDDK
National Institutes of Health
Telephone: (301) 594–8877
Email: hamiltonf@mail.nih.gov

For questions concerning logistical information or registration, contact
Mary Allen
Conference Planner
The Scientific Consulting Group, Inc.
Telephone: (301) 670–4990
Email: mallen@scgcorp.com

Bethesda
 
NIH Campus

Event Details

Background

Functional bowel disorders represent a major health care burden, with significant impact on the quality of life involving at least 10 to 15 percent of the general population. Recent advances suggest that the field is well positioned for transformative advances in our understanding of the pathophysiology, diagnosis and management of these disorders, which will benefit patients. This workshop will focus on elucidating the research gaps in our current knowledge and how to address these gaps in a timely and effective manner.

Meeting Objectives

Functional bowel disorders represent a major health care burden, with significant impact on the quality of life involving at least 10 to 15 percent of the general population. Recent advances suggest that the field is well positioned for transformative advances in our understanding of the pathophysiology, diagnosis, and management of these disorders, which will benefit patients. This workshop will focus on elucidating the research gaps in our current knowledge and how to address these gaps in a timely and effective manner.

Planning Committee

Chair

John Wiley, M.D.
University of Michigan

Members

Lin Chang, M.D.
University of California, Los Angeles

Carlo Di Lorenzo, M.D.
The Ohio State University

Gary Mawe, Ph.D.
University of Vermont

Pankaj (Jay) Pasricha, M.D.
Johns Hopkins Medicine

NIH Staff

Jill Carrington, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Frank A. Hamilton, M.D., M.P.H.
NIDDK

Rebecca Van Raaphorst, M.P.H.
NIDDK​

Registration Deadline

June 19, 2016​​​​​

Agenda

June 23, 2016

   
8:00 a.m. – 8:05 a.m. Welcoming Remarks
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK
   
8:05 a.m. – 8:15 a.m. FBD: Prevalence and Economic Burden
Frank Hamilton, M.D., M.P.H.
   
8:15 a.m. – 8:30 a.m. Introductory Remarks–Functional Bowel Disorders:  Where Are We Now, Where Are We Headed?
Emeran Mayer

Session 1, Part 1

Pathophysiology: Neuromuscular Dysfunction in FBD: Neural, Muscular, Interstitial Cells of Cajal and Glia

Moderators: Michael Camilleri and Gary Mawe
   
8:30 a.m. – 8:50 a.m. FBD: Evidence for Dysmotility
William Hasler
   
8:50 a.m. – 9:10 a.m. Enteric Nervous System: Myenteric and Submucous Plexi
Gary Mawe
   
9:10 a.m. – 9:30 a.m. Interstitial Cells of Cajal and Smooth Muscle: Role in FBD
Kenton Sanders
   
9:30 a.m. – 9:50 a.m. Glia: Control Centers or Active Bystanders in FBD?
Keith Sharkey
   
9:50 a.m. – 10:05 a.m. Panel Discussion: What Are the Gaps and Possible Solutions?
   
10:05 a.m. – 10:20 a.m. Break

Session 1, Part 2

Pathophysiology: Neuromuscular Dysfunction in FBD: Neural, Muscular, Interstitial Cells of Cajal and Glia

Moderators: Emeran Mayer and Gianrico Farrugia
   
10:20 a.m. – 10:40 a.m. The Role of Animal Models in FBD Research
Beverley Greenwood-Van Meerveld
 
10:40 a.m. – 11:00 a.m. Visceral Hypersensitivity: Role of Intestinal Barrier Dysfunction and Altered Permeability
Muriel Larauche
   
11:00 a.m. – 11:20 a.m. Visceral Hypersensitivity: Role of Primary Afferent Neurons and Spinal Pathways
Steve Vanner
   
11:20 a.m. – 11:40 a.m. Visceral Hypersensitivity: Evidence for Altered Regulation in Brain Circuits
Kirsten Tillisch
   
11:40 a.m. – 12:00 p.m. Panel Discussion: Gaps and Possible Solutions
   
12:00 p.m. – 1:00 p.m. Lunch

Session 2, Part 1

FBD: Pathogenesis

Moderators: Magnus Simren and Elena Verdu
   
1:00 p.m. – 1:20 p.m. Post-infection Mechanisms in FBD
Magnus Simren
 
1:20 p.m. – 1:40 p.m. Neuroimmune Mechanisms in FBD: Role of Cellular and Pro-inflammatory Mediators
Terez Shea-Donohue
   
1:40 p.m. – 2:00 p.m. Intraluminal Factors in FBD: Microbiota (Bacteria, Viruses, etc.)
Tor Savidge
   
2:00 p.m. – 2:20 p.m. Intraluminal Factors in FBD: Bile Salts and Other Molecular Species
Michael Camilleri
   
2:20 p.m. – 2:40 p.m. Dietary Triggers in FBD: FODMAP and Other Food Sensitivities
Elena Verdu
   
2:40 p.m. – 3:00 p.m. Environmental Factors and Coping in FBD
Rona Levy
   
3:00 p.m. – 3:15 p.m. Panel Discussion: Gaps and Possible Solutions
   
3:15 p.m. – 3:30 p.m. Break

Session 2, Part 2

FBD: Pathogenesis

Moderators: Nicholas Verne and Miguel Saps
   
3:30 p.m. – 3:50 p.m. Genetic Associations in FBD
Yuri Saito
   
3:50 p.m. – 4:10 p.m. Epigenetic Mechanisms in FBD
John Wiley
   
4:10 p.m. – 4:30 p.m. Early Life Stress and Transgenerational Mechanisms in FBD
Adrian Miranda
   
4:30 p.m. – 4:50 p.m. Gender and FBD
Margaret Heitkemper
   
4:50 p.m. – 5:10 p.m. Psychosocial Factors and Their Relationship to Functional Bowel Disorders
Doug Drossman
   
5:10 p.m. – 5:30 p.m. Panel Discussion: Gaps and Possible Solutions
   
5:30 p.m. Adjournment
   

June 24, 2016

Session 3

Current and Emerging Strategies to Manage FBDs

Moderators: Carlo Di Lorenzo and William Whitehead
   
8:00 a.m. – 8:20 a.m. Current and Emerging Treatments of FBD: Pediatrics
Carlo Di Lorenzo
   
8:20 a.m. – 8:40 a.m. Current and Emerging Treatments of FBD: Adults
William Chey
   
8:40 a.m. – 9:00 a.m. Complementary and Alternative Approaches to Manage FBD
Miranda van Tilburg
   
9:00 a.m. – 9:20 a.m. Biologic Phenotyping in FBDs
Lin Chang
   
9:20 a.m. – 9:35 a.m. Panel Discussion: Gaps and Possible Solutions
   
9:35 a.m. – 9:50 a.m. Break

Session 4

Addressing the Gaps: Application of Next-generation Genomics, Epigenomics, Proteomics, and Pharmacogenomics to Diagnose and Treat FBD

Moderators: Lin Chang and John Wiley
   
9:50 a.m. – 10:20 a.m. Future Directions in Genomics, Epigenomics, and Proteomics to Identify Novel Diagnostic Biomarkers and Therapeutic Targets
Dimitrios Iliopoulos
   
10:20 a.m. – 10:50 a.m. The Emergence of Pharmacogenomics and Its Application to FBD
Wolfgang Sadee
   
10:50 a.m. – 11:20 a.m. Strategies to Strengthen FBD Research and Lessons from Federally Supported Initiatives
Jay Pasricha
   
11:20 a.m. – 11:50 a.m. FBD: The Road to Precision Medicine
Gianrico Farrugia
   
11:50 a.m. – 12:15 p.m. Panel Discussion: Future Directions and How Do We Get There?
   
12:15 p.m. – 12:30 p.m. Closing Remarks
John Wiley
   
12:30 p.m. Adjournment

Directions/Travel

Untitled Document

Hotel Accommodations

Marriott Bethesda
5151 Pooks Hill Road
Bethesda, MD  20814
Telephone: (301) 897-9400, (800) 228-9290

Website: http://www.marriott.com/hotels/travel/wasbt-bethesda-marriott/ 
(More hotel information can be obtained from this website.)

Government Room Rate

A limited block of sleeping rooms for meeting participants has been reserved at the Marriott Bethesda. The rate is the prevailing government rate of $226 per night for single occupancy, plus tax (13%). To reserve a hotel room at the group rate, call reservations at 1-(800)-228-9290 or (301)-897-9400 and identify yourself as a member of the Functional Bowel Disorders Workshop. The room block will be in effect at the Government rate only until Wednesday, May 18, 2016, or until full, whichever comes first. Any room reservations received after this date will be accepted on a space and rate-availability basis.

Reservation Dates

Book arrival on Wendesday, June 22, 2016, and departure on Friday, June 24, 2016. If you require alternate dates, please send an email to Mary Allen of The Scientific Consulting Group, Inc. (SCG) at mallen@scgcorp.com.

Check-in

Please be certain that the hotel provides you with a confirmation number for your reservation. After Wednesday, May 18, 2016, the official room block will be released, and the hotel may charge significantly higher rates and may be sold out. When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 4:00 p.m., and checkout time is 12:00 p.m.

Cancellations

If you need to cancel your reservation, please do so by 4:00 p.m. on the day prior to arrival, or you will be charged a no-show fee for 1 night on your credit card.

NIH Visitor Information 

Information on visiting the NIH, campus maps, shuttle schedules, driving directions, security, and more can be found on the NIH Visitor Information page.

Minutes

Minutes are currently unavailable.

Attendees

Attendees are currently unavailable.

Abstracts

Abstracts are currently unavailable.

Location

Line
  • Building 38A (Lister Hill Center Auditorium)
  • 8600 Rockville Pike
  • MD 20894
Webinar

Contacts

Line ​​For questions concerning program content, contact

Frank A. Hamilton
Program Director
Division of Digestive Diseases and Nutrition
NIDDK
National Institutes of Health
Telephone: (301) 594–8877
Email: hamiltonf@mail.nih.gov

For questions concerning logistical information or registration, contact
Mary Allen
Conference Planner
The Scientific Consulting Group, Inc.
Telephone: (301) 670–4990
Email: mallen@scgcorp.com