U.S. Department of Health and Human Services

Effects of Aging on Hematopoiesis

1/28/2016 12:00 PM
1/29/2016 4:00 PM
Yes
No
​​For questions concerning program content, contact:

Cindy Roy, Ph.D.
Program Director, Hematology
KUH/NIH/NIDDK
6707 Democracy Blvd., Room 639
Bethesda, MD 20817
Phone: (301) 594-8805
Email: cindy.roy@nih.gov

Terry Bishop, Ph.D.
Hematology Program Director
KUH/NIH/NIDDK
6707 Democracy Blvd., Room 619
Bethesda, MD 20817
Phone: (301) 594-7726
Email: terry.bishop@nih.gov

For questions concerning meeting logistics, contact:

John Hare, M.S., CMP, CGMP
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878
Phone: (301) 670-4990
Email: jhare@scgcorp.com

Bethesda
 
Lister Hill Center Auditorium

Event Details

Background

Americans are living longer than ever. The Census Bureau expects that by 2030 one of every five Americans will be age 65 or older. As a result, the focus on diseases that must be addressed by the United States health care system is shifting toward those of older adults. Older adults are faced with a significant burden of non-malignant hematologic disease. The etiologies of anemias, clonal hematopoiesis, idiopathic cytopenia of undetermined significance, and myelodysplastic syndromes are largely unknown, hindering rational diagnosis, treatment, and prevention. Specific hypotheses concerning normal aging of blood stem cells and their progenitors are poised to be tested. Furthermore, we must develop a greater understanding of the pathogenesis of non-malignant hematologic disease in older adults. This workshop will consider the gaps in our knowledge and technology that are barriers to our understanding of the basic biology that regulates hematopoiesis in older organisms. The workshop will also provide an opportunity for the research community to cooperatively consider the essential next steps for the field. We expect that closing such gaps will establish a foundation critical to improving our ability to diagnose, treat, and prevent non-malignant hematologic disease in older adults.​​​​​

Registration Deadline

January 27, 2016​​​

Agenda

Thursday, January 28, 2016​

 

Location: Natcher Balcony A/B,
Bldg. 45, NIH Campus

   
Please note the change in location - all registrants are welcome to attend.
   
  National Institute on Aging (NIA) Special Session
Moderator: Rebecca Fuldner, Ph.D.
   
5:00 p.m. Introduction and Welcome, NIA staff
   
5:15 p.m. Intrinsic and Extrinsic Signals Regulating Hematopoietic Stem Cell Aging
Amy Wagers, Ph.D., Harvard Stem Cell Institute, Harvard University
   
5:45 p.m. Preventing Iatrogenic Hematopoietic Stem Cells (HSC) Aging
Norman Sharpless, M.D., The University of North Carolina School of Medicine
   
6:30 p.m. Dinner on your own
   

Friday, January 29, 2016

 

Location: Lister Hill Auditorium,
Bldg. 38A, NIH Campus

   
8:00 a.m. Introduction and Welcome, NIDDK staff
   
  Session 1: Clonal Hematopoiesis
Moderator: Terry Bishop, Ph.D.
   
8:15 a.m. Clonal Hematopoiesis and Aging
Benjamin Ebert, M.D., Harvard Stem Cell Institute; Dana-Farber Cancer Institute e
   
8:45 a.m. In vivo Stem Cell Clonal Dynamics
Fernando Camargo, Ph.D., Harvard Stem Cell Institute; Boston Children’s Hospital
   
  Director’s Welcoming Remarks
   
9:15 a.m. Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK
   
  Session 2: Epigenetics
Moderator: John Thomas, Ph.D.
   
9:30 a.m. HSCs in the Context of Aging and of Dnmt3a Ablation
Margaret Goodell, Ph.D., Baylor College of Medicine
   
10:00 a.m. Diminished Apoptotic Priming Underlies Increased Survival of Aged HSCs in Response to DNA Damage
Derrick Rossi, Ph.D., Harvard Stem Cell Institute; Harvard University
   
10:30 a.m. Break
   
  Session 3: Lymphoid versus Myeloid Commitment
Moderator: Manjit Hanspal, Ph.D.
   
11:00 a.m. HSCs, Autophagy and Aging
Emmanuelle Passegué, Ph.D., University of California, San Francisco
   
11:30 a.m. Evolving Patterns of Lymphopoiesis from Embryogenesis Through Senescence
Kenneth Dorshkind, Ph.D., University of California, Los Angeles
   
12:00 p.m. The Impact of Aging on Hematopoietic Stem/Progenitor Cells in Non-human Primates as Interrogated by Genetic Barcoding
Cynthia Dunbar, M.D., National Heart, Lung, and Blood Institute
   
12:30 p.m. DNA Damage Checkpoints in Hematopoietic Stem Cells Influence Immune Functions and Leukemogenesis in Aging
K. Lenhard Rudolph, M.D., Leibniz Institute on Aging
   
1:00 p.m. Lunch and Poster Session
   
  Session 4: Aging Microenvironment
Moderator: John Williams, Ph.D.
   
2:30 p.m. Aging Alters the Bone Marrow Microenvironment
Laura Calvi, M.D., University of Rochester School of Medicine
   
3:00 p.m. Effects of Bone on Hematopoietic Aging and Disease
Stavroula Kousteni, Ph.D., Columbia University
   
  Wrap up: Themes and Future Directions
Moderator: Terry Bishop, Ph.D.
   
3:30 p.m. Margaret Goodell, Ph.D., Baylor College of Medicine
   
3:45 p.m. Next Steps and Future Directions, NIDDK Staff
   
4:30 p.m. Adjournment

Directions/Travel

Hotel Accommodations

Hyatt Regency Bethesda Hotel 
One Bethesda Metro Center
7400 Wisconsin Avenue
Bethesda, MD  20814  
Telephone: (301) 657-1234 or (888) 421-1442
Fax: (301) 657-6453

Website: http://www.hyattregencybethesda.com 
(More hotel information can be obtained from this website.)

Government Room Rate

A limited block of sleeping rooms for meeting participants has been reserved at the Hyatt Regency Bethesda. The rate is the prevailing government rate of $179 per night for single occupancy, plus tax (13%). To reserve a hotel room at the group rate, call reservations at (888) 421-1442 and identify yourself as a member of the Effects of Aging Workshop or click on this link: to book your group. The room block will be in effect at the Government rate only until Monday, December 28, 2015, or until full, whichever comes first. Any room reservations received after this date will be accepted on a space and rate-availability basis.

Reservation Dates

Book arrival on Thursday, January 28, 2016, and departure on Friday, January 29, 2015. If you require alternate dates, please send an email to John Hare of The Scientific Consulting Group, Inc. (SCG) at jhare@scgcorp.com. Any alternate date requests will need to be approved through the NIDDK.

Check-in

Please be certain that the hotel provides you with a confirmation number for your reservation. After December 28, 2015, the official room block will be released, and the hotel may charge significantly higher rates and may be sold out. When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 4:00 p.m., and checkout time is 12:00 p.m.

Cancellations

If you need to cancel your reservation, please do so by 4:00 p.m. on the day prior to arrival, or you will be charged a no-show fee for 1 night on your credit card.

NIH Visitor Information 

Information on visiting the NIH, campus maps, shuttle schedules, driving directions, security, and more can be found on the NIH Visitor Information page.

Minutes

Minutes are currently unavailable.

Attendees

Attendees are currently unavailable.

Abstracts

Call for Abstracts

Submission Deadline

Monday, December 14, 2015

Notification of Acceptance

December 21, 2015

Abstract Instructions

Participants in the Effects of Aging on Hematopoiesis workshop, are encouraged to submit abstracts of their research activities. In addition to an opportunity to present their research in a poster session, conference attendees will find additional career development and networking opportunities with other researchers. All submitted abstracts will be accepted for poster presentation.

All abstracts must be submitted via email to John Hare of The Scientific Consulting Group, Inc. at jhare@scgcorp.com with “Hematopoiesis Abstract” in the subject line. Abstract submissions should be no longer than 250 words (not including name and affiliation).

Please follow the instructions below to submit an abstract for consideration (Download Template).

  1. Indicate the career stage of the submitting author (student, fellow, instructor, assistant professor, etc.)
  2. The abstract should be an MS Word document typed single-spaced using 12 point Times New Roman font. The abstract’s title should be Bold, 16 pt., Title Case font and should clearly represent the nature of the investigation. The title should be followed in lowercase letters by the author’s first and last names, degree, and affiliation, city, state, and country. Underline the primary author’s name (one primary author per abstract). Use one blank line between the title and the body of the abstract and between paragraphs. The abstract file should be saved as: primary authors’ last name_first word in the title (e.g., Zucker_Effects).
  3. Please ensure that your abstract is the correct length and use 1" margins.
  4. Use of standard abbreviations is desirable (e.g., RBC) as well as standard symbols for units of measure (e.g., kg, gm, mg, mL, L, and %). Place a special or unusual abbreviation in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subtitles (e.g., Methods, Results).
  5. Simple tables or graphs may be included; however, they must fit within the designated abstract space of one page.

Junior level participants (students, fellows, instructors and assistant professors) with the highest scoring abstracts will be eligible for a modest travel award. Travel award notifications will be made by January 4, 2016.

Poster Presentations

Poster presentations will be displayed on 4-foot-high by 6-foot-wide poster boards. Pushpins and Velcro will be provided onsite. Please arrive between 7:30 and 8:00 a.m., January 29, 2016, to mount your poster on the posterboard and then remove your poster at the end of the meeting. You will be responsible for removing and shipping your poster. All presenters must pre-register for the conference.

If you have any questions about the scientific content of the workshop, please contact Dr. Cindy Roy at cindy.roy@nih.gov. For questions/concerns about workshop logistics, please contact Mr. John Hare at jhare@scgcorp.com. We look forward to meeting and working with you and anticipate a stimulating and productive workshop.​

Location

Line
  • National Library of Medicine 8600 Rockville Pike
  • NIH Building 38A
  • MD 20894
Webinar

Contacts

Line ​​For questions concerning program content, contact:

Cindy Roy, Ph.D.
Program Director, Hematology
KUH/NIH/NIDDK
6707 Democracy Blvd., Room 639
Bethesda, MD 20817
Phone: (301) 594-8805
Email: cindy.roy@nih.gov

Terry Bishop, Ph.D.
Hematology Program Director
KUH/NIH/NIDDK
6707 Democracy Blvd., Room 619
Bethesda, MD 20817
Phone: (301) 594-7726
Email: terry.bishop@nih.gov

For questions concerning meeting logistics, contact:

John Hare, M.S., CMP, CGMP
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878
Phone: (301) 670-4990
Email: jhare@scgcorp.com