U.S. Department of Health and Human Services
Hemodialysis Vascular Access: Taking the Next Steps

Hemodialysis Vascular Access: Taking The Next Steps

9/16/2015 12:00 AM
9/17/2015 12:00 AM
Yes
No
For questions concerning program content, contact:
Kevin Abbott, M.D., M.P.H.
Program Officer, KUH, NIDDK, NIH
Room 621
6707 Democracy Boulevard
Bethesda, MD 20892
Phone: (301) 594-7714
Email: kevin.abbott@nih.gov
 
John W. Kusek, Ph.D.
Senior Scientific Advisor, KUH, NIDDK, NIH
6707 Democracy Boulevard
Bethesda, MD 20892
Phone: (301) 594-7735
Email: kusekj@extra.niddk.nih.gov
 
Daniel Gossett, Ph.D.
Presidential Management Fellow-STEM, KUH, NIDDK, NIH
6707 Democracy Boulevard
Bethesda, MD 20892
Phone: (301) 594-7723
Email: daniel.gossett@nih.gov
 
​​For questions concerning meeting logistics, contact:
Robert Watson, CMP
The Scientific Consulting Group, Inc.
656 Quince Orchard Road
Suite 210
Gaithersburg, MD 20878
Phone: (301) 670-4990
Fax: (301) 670-3815
Email: rwatson@scgcorp.com​​​​​​
Bethesda
 
Natcher Conference Center

Event Details

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), is pleased to announce the workshop on Hemodialysis Vascular Access. This meeting will take place September 16–17, 2015, and will be held at the Natcher Conference Center on the NIH Main Campus in Bethesda, MD. The purpose of the workshop is to review the state-of-the-art knowledge of the clinical, epidemiological, and basic research aspects of arteriovenous fistulas and grafts to support maintenance hemodialysis.​​​​​​​​

Agenda

Wednesday, September 16, 2015
7:00 – 8:00 a.m. Registration
8:00 – 8:10 a.m. Welcome from NIDDK
Robert Star, Division of Kidney, Urologic, and Hematologic Diseases (KUH), NIDDK
8:10 – 8:20 a.m. Overview of the Workshop
Michael Allon, The University of Alabama at Birmingham School of Medicine
Epidemiology of Vascular Access and Factors Associated with Arteriovenous Fistula (AVF) Development and Maturation
Moderator: Michael Allon, The University of Alabama at Birmingham School of Medicine
8:20 – 8:40 a.m. Recent U.S. Trends in Vascular Access: Data from DOPPS and USRDS/CrownWeb
Rajiv Saran, University of Michigan Medical School
8:40 – 9:00 a.m. Postoperative Ultrasound Changes in AVF Diameter and Blood Flow in the Hemodialysis Fistula Maturation (HFM) Study and Their Association with Clinical AVF Maturation
Michelle Robbin, The University of Alabama at Birmingham School of Medicine
9:00 – 9:20 a.m. Clinical Factors Affecting Postoperative AVF Diameter and Blood Flow and Clinical Maturation in the HFM Study
Scott Berceli, University of Florida
9:20 – 9:40 a.m. Preoperative Vascular Function Tests and Their Association with Postoperative AVF Diameter and Blood Flow and Clinical Maturation in the HFM Study
Laura Dember, University of Pennsylvania Perelman School of Medicine
9:40 – 10:00 a.m. FDA Perspective: What Are Acceptable Outcome Measures for Intervention/Treatment Studies of Hemodialysis Vascular Access?
Brian Pullin, U.S. Food and Drug Administration
10:00 – 10:20 a.m. Break
Improving Vascular Access Outcomes
Moderators: Dennis Bandyk, University of California, San Diego School of Medicine, and
  Tom Huber, University of Florida College of Medicine
10:20 – 10:35 a.m. Optimal Use of Imaging and Surgical Techniques to Improve Access Outcomes
Tom Huber, University of Florida College of Medicine
10:35 – 10:50 a.m. Long-term Vascular Access Planning: AVF, Arteriovenous Graft (AVG), or Central Venous Catheter (CVC)?
Karen Woo, Keck School of Medicine of the University of Southern California
10:50 – 11:05 a.m. What Is the Optimal Timing of Predialysis Vascular Access?
Matthew Oliver, Sunnybrook Health Sciences Centre
11:05 – 11:20 a.m. Percutaneous Interventions to Salvage Nonmaturing AVF
Monnie Wasse, Northwestern University Feinberg School of Medicine
11:20 – 11:40 a.m. Processes of Care That Affect Clinical AVF Maturation—Results from the HFM Study
Alfred Cheung, The University of Utah Health Sciences Center
11:40 – 11:55 a.m. Changing Processes of Care to Convert Catheter-dependent HD Patients to Permanent Access
George Blessios, Mercy Hospital Dialysis Access Center
11:55 a.m. – 12:10 p.m. Drug Interventions to Prevent Access Failure: Results of Major RCTs
Charmaine Lok, University Health Network, University of Toronto
12:10 – 1:30 p.m. Lunch
Biology of Vascular Access Failure and Potential Molecular Targets
Moderators: Roberto Vazquez-Padron, University of Miami Miller School of Medicine, and
  Timmy Lee, The University of Alabama at Birmingham School of Medicine
1:30 – 1:45 p.m. Overview of Failing AVF and AVG
Prabir Roy-Chaudhury, University of Arizona
1:45 – 2:05 p.m. Preexisting Vascular Pathology and Its Association with Postoperative AVF Diameter and Blood Flow and Clinical Maturation—Findings from the HFM Study
Charles Alpers, University of Washington School of Medicine
2:05 – 2:25 p.m. Preexisting Venous Intimal Hyperplasia and Its Impact on Postoperative Neointimal Hyperplasia and Clinical AVF Outcomes
Roberto Vazquez-Padron, University of Miami Miller School of Medicine
2:25 – 2:45 p.m. Impact of Preexisting Arterial and Venous Pathology on Clinical AVF and AVG Outcomes
Michael Allon, The University of Alabama at Birmingham School of Medicine
2:45 – 3:00 p.m. Hemodynamic Changes and Vascular Access Outcomes
Andrea Remuzzi, Mario Negri Institute
3:00 – 3:15 p.m. Molecular Targets in Experimental Models of AVF and AVG Failure
Sanjay Misra, Mayo Clinic
3:15 – 3:30 p.m. Molecular Targets in Clinical AVF and AVG Failure
Timmy Lee, The University of Alabama at Birmingham School of Medicine
3:30 – 4:00 p.m. Break
Industry Roundtable: Future Directions to Prevent Vascular Access Failure and Perspective on Conducting Clinical Trials of Hemodialysis Vascular Access
Moderator: Keith Ozaki, Brigham and Women’s Hospital
4:00 – 4:15 p.m. Use of Elastase to Improve AVF Maturation
Steve Burke, Proteon Therapeutics, Inc.
4:15 – 4:30 p.m. Tissue Engineered Scaffolds for Improved AVGs (Humacyte)
Jeff Lawson, Duke University Medical Center
4:30 – 4:45 p.m. Sirolimus Wraps
Sriram Iyer, Vascular Therapies, Inc.
4:45 – 5:00 p.m. Optiflow Device
Adam Dakin, Bioconnect Systems, Inc.
5:00 – 5:15 p.m. Open Discussion: Opportunities and Challenges in the Business of Improving Vascular Access Outcomes
Industry Speakers and Participants
5:15 – 5:30 p.m. Charge to the Breakout Sessions
Michael Allon, The University of Alabama at Birmingham School of Medicine
5:30 p.m. Adjournment for the Day
   
Thursday, September 17, 2015
7:30 – 8:30 a.m. Industry-sponsored breakfast and poster session
8:30 a.m. – 12:00 p.m. Concurrent Breakout Sessions
 
  • How Can We Improve Processes of Care to Reduce Catheter Use in HD Patients?
    Moderators: Dennis Bandyk, University of California, San Diego School of Medicine, and Karen Woo, Keck School of Medicine of the University of Southern California
  • Emerging Percutaneous and Surgical Interventions to Improve Vascular Access Outcomes
    Moderators: Keith Ozaki, Brigham and Women’s Hospital, and Monnie Wasse, Northwestern University Feinberg School of Medicine
  • Promising Pharmacologic Approaches to Prevention of Vascular Access Failure
    Moderators: Roberto Vazquez-Padron, University of Miami Miller School of Medicine, and Timmy Lee, The University of Alabama at Birmingham School of Medicine
  • Future Epidemiologic Studies and Clinical Trials of Vascular Access
    Moderators: Charmaine Lok, University Health Network, University of Toronto, and Prabir Roy-Chaudhury, University of Arizona
12:00 – 1:00 p.m. Lunch
Summary and Recommendations from the Breakout Sessions
Moderator: Michael Allon, The University of Alabama at Birmingham School of Medicine
1:00 – 1:20 p.m. GROUP 1: Presentation and Discussion
Dennis Bandyk, University of California, San Diego School of Medicine, and
Karen Woo, Keck School of Medicine of the University of Southern California
1:20 – 1:40 p.m. GROUP 2: Presentation and Discussion
Keith Ozaki, Brigham and Women’s Hospital, and
Monnie Wasse, Northwestern University Feinberg School of Medicine
1:40 – 2:00 p.m. GROUP 3: Presentation and Discussion
Roberto Vazquez-Padron, University of Miami Miller School of Medicine, and
Timmy Lee, The University of Alabama at Birmingham School of Medicine
2:00 – 2:20 p.m. GROUP 4: Presentation and Discussion
Charmaine Lok, University Health Network, University of Toronto, and
Prabir Roy-Chaudhury, 
University of Arizona​
Concluding Remarks
2:20 – 2:40 p.m. Meeting Summary
Michael Allon, The University of Alabama at Birmingham School of Medicine
2:40 – 2:50 p.m. Concluding Remarks
Robert Star, KUH, NIDDK
2:50 p.m. Adjournment

Directions/Travel

Travel Arrangements
Participants are responsible for making their own travel arrangements. If you decide to extend your stay to take advantage of lower fares, DC-area attractions are only a short stop away from the suggested hotel.

Hotel and travel information are listed below.


Hotel Reservations 
The following hotels provide lodging in relatively close proximity that is accessible by taxi.

Bethesda Marriott Hotel
5151 Pooks Hill Road 
Bethesda, MD  20814 
Phone: 301-897-9400 or 1-800-228-9290
Distance to NIH Campus: 1.4 mi.
 
Bethesda North Marriott Hotel & Conference Center
5701 Marinelli Road 
North Bethesda, MD  20852 
Phone: 301-822-9200 or 1-800-228-9290 
Distance to NIH Campus: 3.6 mi.
 
Hilton Executive Conference Center
1750 Rockville Pike 
Rockville, MD  20852 
Phone: 301-468-1100 or 1-800-HILTONS
Distance to NIH Campus: 4.7 mi.

Hyatt Regency Bethesda
One Bethesda Metro Center 
Bethesda, MD  20814 
Phone: 301-657-1234 or 1-800-633-7313 
Distance to NIH Campus: 1.2 mi.

DoubleTree Hotel
8120 Wisconsin Avenue 
Bethesda, MD  20814
Phone: 301-652-2000 or 1-800-222-TREE
Distance to NIH Campus: 0.5 mi. 

American Inn of Bethesda
8130 Wisconsin Avenue 
Bethesda, MD  20814 
Phone: 301-656-9300 or 1-800-232-7081 
Distance to NIH Campus: 0.5 mi.

Residence Inn 
7335 Wisconsin Avenue 
Bethesda, MD  20814
Phone: 301-718-0200 or 1-800-228-9290
Distance to NIH Campus: 1.2 mi.

Hilton Garden Inn
7301 Waverly Street
Bethesda, MD  20814
Phone: 301-654-8111
Distance to NIH Campus: 1.3 mi.


Taxi Service to Area Hotels
From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Approximate hotel distance and direction: 35 miles S.W.
Estimated Taxi Fare: $70

From Washington Dulles International Airport (IAD):
Approximate hotel distance and direction: 25 miles N.E.
Estimated Taxi Fare: $60

From Ronald Reagan Washington National Airport (DCA):
Approximate hotel distance and direction: 21 miles N.E.
Estimated Taxi Fare: $50

Fares may differ during peak travel hours.


Metro to the Hotel
The Metro system is clean and reliable. It operates from 5:00 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays. Each passenger must purchase a farecard to travel in the system. Instructions for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map of the system. Station attendants on duty at each station can provide additional information on request. From Ronald Reagan Washington National Airport, a cost-effective way to travel to the meeting is by using the Metrorail system. A map of the system is available at: http://www.wmata.com/rail/maps/map.cfm.

From the Ronald Reagan Washington National Airport station, take the Yellow Line toward Mt. Vernon Square or Fort Totten. At the Gallery/Chinatown stop, transfer to the Red Line toward Shady Grove or Grosvenor-Strathmore. Please see the following list of hotels and respective Metro stations.

Bethesda Station – Hyatt Regency, Residence Inn, Hilton Garden Inn
Medical Center Station* – American Inn, DoubleTree, Bethesda Marriott (call for hotel shuttle)
White Flint Station – Bethesda Marriott North Hotel and Conference Center
Twinbrook – Hilton Executive Conference Center

*The NIH campus is located at Medical Center Station.

SuperShuttle
SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrangements for a shuttle can be made by calling 1-800-258-3826 from the airport, or visit their website at http://supershuttle.com.


NIH Visitor Information
The Natcher Conference Center is located on the NIH Campus in Building 45. For a map, general information, and directions to and around the NIH Campus, visit http://www.ors.od.nih.gov/maps/Pages/NIH-Visitor-Map.aspx.


NIH Security
The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors. The national threat advisory level is determined by the Department of Homeland Security (http://www.whitehouse.gov/homeland/).

Perimeter Security
All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus. Visitors will be asked to show one (1) form of identification (a government-issued photo ID: driver’s license, passport, green card, etc.) and to state the purpose of their visit. Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Security
Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day.

Employees and visitors should continue to wear their identification prominently at all times while on campus.

Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns. At building entrances where guards are posted:

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge).
  • Visitors may be required to log-in, wear a visitor’s pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings.
  • Security staff will confiscate any suspicious or potentially dangerous materials. U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches. Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection.

Weekday Pedestrian Campus Access
All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center (see the Gatewayr Map at http://www.ors.od.nih.gov/maps/Pages/Gateway-Center-Map.aspx).

  • Gateway Center
    Wisconsin Avenue at Gateway Drive (near the Metro)
    Open 24 hours, 7 days per week
  • West Gateway Center
    Near Old Georgetown Road and South Drive
    Open 6:00 a.m. – 12:00 p.m., Monday-Friday

Driving Directions to NIH
From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

From Points North and West:
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson’s Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495). Continue approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway). Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.


Parking
Parking on the NIH campus is limited and is $12 per day in the visitor lots. A large parking garage is located at Gateway Center, just outside security. It is a 5-minute walk from there to Building 45.​​​

Minutes

Minutes are currently unavailable.

Attendees

Planning Group
Workshop on Hemodialysis Vascular Access
September 16-17, 2015

Roster

Michael Allon, M.D. (Planning Group Leader)
Professor of Medicine
University of Alabama at Birmingham
Birmingham, Alabama

Kevin C. Abbott, M.D., M.P.H.
Director, Kidney and Urology Epidemiology
Division of Kidney, Urologic and Hematologic Diseases (DKUHD)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health (NIH)
Bethesda, Maryland

Dennis Bandyk, M.D., F.A.C.S.
Professor of Surgery
University of California-San Diego School of Medicine
La Jolla, California

Daniel Gossett, Ph.D.
Health Specialist, Small Business Programs
DKUHD, NIDDK, NIH

John W. Kusek, Ph.D.
Senior Scientific Advisor
DKUHD, NIDDK, NIH

C. Keith Ozaki, M.D., F.A.C.S.
John A Mannick Professor of Surgery
Brigham and Women’s Hospital
Harvard Medical School
Boston, Massachusetts

Surendra Shenoy, M.D., Ph.D.
Professor of Surgery
Washington University School of Medicine
St. Louis, Missouri

Roberto I. Vazquez-Padron, Ph.D.
Associate Professor of Surgery
University of Miami Leonard M. Miller School of Medicine
Miami, Florida​

Abstracts

Submission Deadline: Monday, August 31, 2015

Participants in the Hemodialysis Vascular Access workshop, are encouraged to submit abstracts of their research activities. In addition to an opportunity to present their research in a poster session, conference attendees will find additional career development and networking opportunities with other researchers. All submitted abstracts will be accepted for poster presentation.

All abstracts must be submitted via email to Robert Watson of The Scientific Consulting Group, Inc. at rwatson@scgcorp.com with “Hemodialysis Abstract” in the subject line. Abstract submissions should be no longer than 250 words (not including name and affiliation).

Please follow the instructions below to submit an abstract for consideration:

  1. The abstract should be an MS Word document typed single-spaced using 12 point Times New Roman font. The abstract’s title should be Bold, 16 pt., Title Case font and should clearly represent the nature of the investigation. The title should be followed in lowercase letters by the author’s first and last names, degree, and affiliation, city, state, and country. Underline the primary author’s name (one primary author per abstract). Use one blank line between the title and the body of the abstract and between paragraphs. The abstract file should be saved as: primary authors’ last name_first word in the title (e.g., Zucker_Effects).
  2. Please ensure that your abstract is the correct length and use 1" margins.
  3. Use of standard abbreviations is desirable (e.g., RBC) as well as standard symbols for units of measure (e.g., kg, gm, mg, mL, L, and %). Place a special or unusual abbreviation in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subtitles (e.g., Methods, Results).
  4. Simple tables or graphs may be included; however, they must fit within the designated abstract space of one page.

Body of the Abstract

  1. Organize the body of the abstract as follows:
    • Statement of the purpose of the study/program/project;
    • Statement of the methods used;
    • Summary of the results presented in sufficient detail to support the conclusion; and>
    • Statement of the conclusions reached.

POSTER PRESENTATIONS

Poster presentations will be displayed on 4-foot-high by 6-foot-wide poster boards. Pushpins and Velcro will be provided onsite.

All presenters must pre-register for the conference. ​​

Location

Line
  • Building 45
  • National Institutes of Health (NIH)
  • MD 20894
Webinar

Contacts

Line For questions concerning program content, contact:
Kevin Abbott, M.D., M.P.H.
Program Officer, KUH, NIDDK, NIH
Room 621
6707 Democracy Boulevard
Bethesda, MD 20892
Phone: (301) 594-7714
Email: kevin.abbott@nih.gov
 
John W. Kusek, Ph.D.
Senior Scientific Advisor, KUH, NIDDK, NIH
6707 Democracy Boulevard
Bethesda, MD 20892
Phone: (301) 594-7735
Email: kusekj@extra.niddk.nih.gov
 
Daniel Gossett, Ph.D.
Presidential Management Fellow-STEM, KUH, NIDDK, NIH
6707 Democracy Boulevard
Bethesda, MD 20892
Phone: (301) 594-7723
Email: daniel.gossett@nih.gov
 
​​For questions concerning meeting logistics, contact:
Robert Watson, CMP
The Scientific Consulting Group, Inc.
656 Quince Orchard Road
Suite 210
Gaithersburg, MD 20878
Phone: (301) 670-4990
Fax: (301) 670-3815
Email: rwatson@scgcorp.com​​​​​​