U.S. Department of Health and Human Services
The Pediatric Acute Liver Failure of Undetermined Cause: A Clinical Research Workshop October 16, 2015 banner image

Pediatric Acute Liver Failure of Undetermined Cause: A Clinical Research Workshop

10/16/2015 8:15 AM
10/16/2015 5:00 PM
Yes
No
​​Registration/Information 

To register, email: 
Lauren Meskill
Suprvisory Program Analyst
Division of Digestive Diseases and Nutrition
NIDDK
National Institutes of Health
MeskillL@mail.nih.gov
Bethesda
 
NIH Campus

Event Details

​​Event Details

A one day research workshop bringing together clinical and translational investigators to define the clinical and pathophysiological aspects that characterize acute pediatric acute liver failure due to an undefined cause, currently labeled as indeterminate etiology.

Organizing Committee: Estella Alonso (LURIE), Simon Horslen (Seattle CH), Edward Behernsn (CHOP), Averell Sherker (NIDDK), Edward Doo (NIDDK), Jay Hoofnagle (NIDDK)

When

October 16, 2015
8:15 a.m. to 5:00 p.m.

Where

NIH Campus
Natcher Conference Center, Rm E1/E2
45 Center Drive, Bethesda, MD

Note: This conference has an attendance cap of 100.

Food: Conference attendees and/or presenters are responsible for meals and/or light refreshments on their own and at their own cost. Government staff and/or government contractors may not be involved in the provision or facilitation of food and/or light refreshments for conference attendees and/or presenters.
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Agenda

8:15-8:30 AM: Welcome and Introduction-Estella Alonso and Edward Doo 

Session 1: Clinical and Pathophysiological Features of PALF of Undetermined Cause (Simon Horslen-moderator)
8:30-8:50 ALF of undetermined cause in children Estella Alonso
8:50-9:10 ALF of undetermined in adults Todd Stravitz
9:10-9:30 Pathology of Acute Liver Failure David Kleiner
9:30-9:50 Inflammatory Milieu in PALF Ed Behrens
9:50-10:10 Discussion

10:10-10:30 Break

Session 2: Pathophysiological Mechanisms and Regeneration in Acute Liver Failure (Ed Behrens -moderator)
10:30-10:50 Mechanisms of Immune Mediated Liver Injury Harmut Jaeschke
10:50-11:10 Modeling of Inflammatory Cascades in PALF Yoram Vodovotz
11:10-11:30 Growth Factors in Hepatic Regeneration David Rudnick
11:30-11:50 The Endothelial Cell in Hepatic Regeneration Laurie DeLeve
11:50-12:10 Discussion

12:10-1:20 Lunch (on your own)

Session 3: Elucidation of Etiologies of PALF of Undetermined Cause (David Rudnick -moderator)
1:20-1:40 Viral etiology discovery for PALF of undetermined cause Charles Chiu
1:40-2:00 Genomic approaches for the discovery of genetic variations that may be associated with PALF of undetermined cause Mark Yandell
2:00-2:20 Discussion

2:20-2:40 Break

Session 4: Potential Therapeutic Targets and Approaches for PALF of Undetermined Cause(Kathleen Loomes-moderator)
2:40-3:00 Drug Therapeutic Targets for Cytokine Storm, MAS and HLH Alexei Grom
3:00-3:20 Ongoing Treatment Trials and New Strategies Simon Horlsen
3:20-3:40 Treating Neuroinflammation Mark Wainwright
3:40-4:00 Discussion

4:00-4:15 Break

Session 5: Defining research challenges, priorities, and opportunities for PALF of Undetermined Cause (Alonso, Horslen, Beherns — moderators)
4:15-5:00 Defining research challenges, priorities, and opportunities for Indeterminate PALF Audience and Moderators

Directions/Travel

Travel Arrangements

The following hotels provide lodging in relatively close proximity that is accessible by taxi. Some are within walking distance and some offer complimentary shuttle service to the NIH.

Bethesda Marriott Hotel (Shuttle service)
5151 Pooks Hill Road
Bethesda, MD 20814
Phone: 301-897-9400 or 1-800-228-9290

Bethesda North Marriott Hotel & Conference Center
5701 Marinelli Road
North Bethesda, MD 20852
Phone: 301-822-9200 or 1-800-228-9290 ​

Hyatt Regency Bethesda (Metro stop location)
One Bethesda Metro Center
Bethesda, MD 20814
Phone: 301-657-1234 or 1-800-633-7313

Doubletree Hotel (Walkable)
8120 Wisconsin Avenue
Bethesda, MD 20814
Phone: 301-652-2000 or 1-800-222-TREE

American Inn of Bethesda
8130 Wisconsin Avenue
Bethesda, MD 20814
Phone: 301-656-9300 or 1-800-232-7081

Residence Inn
7335 Wisconsin Avenue
Bethesda, MD 20814
Phone: 301-718-0200 or 1-800-228-9290 ​



Taxi Service to Area Hotels

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Approximate hotel distance and direction: 35 miles S.W.
Estimated Taxi Fare: $60

From Washington Dulles International Airport (IAD): Approximate hotel distance and direction: 25 miles N.E.
Estimated Taxi Fare: $50

From Ronald Reagan Washington National Airport (DCA): Approximate hotel distance and direction: 21 miles N.E.
Estimated Taxi Fare: $45
Fares may differ during peak travel hours. ​

NIH Visitor Information

The Natcher Building is located on the NIH Campus at 45 Center Drive (Building 45). It is a very short distance from the Medical Center Metro stop. For a map, general information, and directions to and around the NIH Campus, visit http://www.ors.od.nih.gov/maps/Pages/NIH-Visitor-Map.aspx.


NIH Security

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors. The national threat advisory level is determined by the Department of Homeland Security (http://www.whitehouse.gov/homeland).

Perimeter Security

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus. Visitors will be asked to show one (1) form of identification (a government-issued photo ID: driver’s license, passport, green card, etc.) and to state the purpose of their visit. Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Security

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day. Employees and visitors should continue to wear their identification prominently at all times while on campus. Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns. At building entrances where guards are posted:

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge
  • Visitors may be required to log-in, wear a visitor’s pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings.
  • Security staff will confiscate any suspicious or potentially dangerous materials. U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches. Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection.

Weekday Pedestrian Campus Access

All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center (see the Gateway Map at http://www.ors.od.nih.gov/maps/Pages/Gateway-Center-Map.aspx).

  • Gateway Center
Wisconsin Avenue at Gateway Drive (near the Metro)
Open 24 hours, 7 days per week
  • West Gateway Center
Near Old Georgetown Road and South Drive
Open 6:00 a.m. – 12:00 p.m., Monday-Friday

Driving Direction to NIH


From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive.

From Points North and West:
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Travel approximately 1 mile and turn right at the light onto South Drive.

From Point South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson’s Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive.

From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495). Continue approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Travel approximately 1 mile and turn right at the light onto South Drive.

From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway). Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive.

Parking

Parking on the NIH campus is limited and is $12 per day in the visitor lots.​

Minutes

Minutes are currently unavailable.

Attendees

Attendees are currently unavailable.

Abstracts

Abstracts are currently unavailable.

Location

Line
  • Natcher Conference Center, Rm E1/E2
  • 45 Center Drive
  • MD
Webinar

Contacts

Line ​​Registration/Information 

To register, email: 
Lauren Meskill
Suprvisory Program Analyst
Division of Digestive Diseases and Nutrition
NIDDK
National Institutes of Health
MeskillL@mail.nih.gov