U.S. Department of Health and Human Services

Regulatory Determinants of Hematopoietic Stem Cell Differentiation and Terminal Development: New Insights

2/20/2012 7:00 AM
2/20/2012 7:00 AM

Event Details

Meeting Objective

On February 20, 2012 , the Hematology Program of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH) will host a one-day workshop on Regulatory Determinants of Hematopoietic Stem Cell Self-Renewal, Lineage Commitment and Terminal Differentiation: New Insights . This state-of-the-science workshop will take place at The American Institute of Architects building in Washington, DC. The objectives of the workshop are to provide an opportunity for research leaders in the field of hematopoietic stem cell (HSC) biology to review and discuss current understanding of how HSC self-renewal, lineage commitment, and terminal differentiation are regulated; to define knowledge gaps and key unanswered questions in these critical aspects of HSC biology; and to define opportunities, directions, and priorities for future research that will address these questions. The program will include presentations by both invited speakers and speakers selected from submitted abstracts, together with poster presentations.
A limited number of travel grants will be made available to registrants whose abstracts are selected for oral presentation at the workshop. Space at the workshop will be limited, so early registration is encouraged. Registrants who submit abstracts for presentation at the workshop will be given preference if the number of registrants exceeds available space. Questions regarding abstract submission and/or registration should be directed to Dr. Wright at daniel.wright@nih.gov .

Workshop Co-organizers and Consultant:

Daniel Tenen (Harvard University); Gerd Blobel (University of Pennsylvania); Tannistha Reya (University of California, San Diego); Marc Groudine (University of Washington); Daniel Wright (NIDDK, NIH); Terry Bishop (NIDDK, NIH)


  • Transcriptional regulation of gene activation and silencing relevant to hematopoietic lineage commitment and differentiation
  • Epigenetic determinants of hematopoietic differentiation and terminal development
  • Determinants of HSC self-renewal versus lineage commitment and differentiation in the hematopoietic niche

Invited Speakers:

Dan Tenen Bethesda Israel Deaconess/Harvard University
Utpal Banerjee University of California, Los Angeles
Len Zon Children's Hospital Boston/Harvard University
Merav Socolovsky University of Massachusetts
Emery Bresnick University of Wisconsin
Gerd Blobel University of Pennsylvania
Peggy Goodell Baylor University
Indika Rajapakse University of Washington
Frank Rosenbauer Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
Irv Bernstein University of Washington
Tannishtha Reya University of California, San Diego
David Scadden Massachusetts General Hospital/Harvard University
Timm Schroeder Helmholtz Zentrum, Munich, Germany
Paul Frenette Albert Einstein College of Medicine of Yeshiva University
John Chang University of California, San Diego


7:30 a.m. - 8:15 a.m.

Registration and Poster Set-up

8:15 a.m. - 8:30 a.m. Welcome and Opening Remarks: Dr. Daniel Wright

Session 1:

Transcriptional Regulation of Gene Activation and Silencing Relevant To Hematopoietic Lineage Commitment and Differentiation

8:30 a.m. - 12 p.m. Presentations by Drs. Dan Tenen (Bethesda Israel Deaconess/Harvard University), Utpal Banerjee , (University of California, Los Angeles), Len Zon (Children's Hospital Boston/Harvard University), Merav Socolovsky (University of Massachusetts), Emery Bresnick (University of Wisconsin) and from selected submitted abstracts (including a mid-morning coffee break and informal poster viewing)
12:00 p.m. - 1:15 p.m. Lunch in AIA Building Foyer (participants to pre-pay) and Poster Viewing

Session 2:

Epigenetic Determinants of Hematopoietic Differentiation and Terminal Development

1:15 p.m. - 3:45 p.m. Presentations by Drs. Gerd Blobel (University of Pennsylvania), Peggy Goodell (Baylor University), Indika Rajapakse (University of Washington), Irv Bernstein (University of Washington), Frank Rosenbauer (Max-Delbrück-Center for Molecular Medicine, Berlin, Germany) and from selected submitted abstracts(including a mid-afternoon coffee break and additional poster viewing)

Session 3:

Determinants of HSC Self-Renewal Versus Lineage Commitment and Differentiation in the Hematopoietic Niche

3:45 p.m. - 6:00 p.m. Presentations by Drs. Tannishtha Reya (UCSD), Timm Schroeder (Helmholtz Zentrum, Munich, Germany), David Scadden (Massachusetts General Hospital/Harvard University), John Chang (University of California, San Diego), Paul Frenette (Albert Einstein College of Medicine of Yeshiva University) and from selected submitted abstracts.

Workshop Summary and Final Discussion

6:00 p.m. - 6:30 p.m. Moderators: Drs. Tenen, Blobel, and Reya
6:30 p.m. Workshop Adjournment and Final Poster Viewing and Discussion


​Directions/Travel is currently unavailable.


Minutes are currently unavailable.


​Attendees are currently unavailable.



All workshop participants, as well as all invited speakers , who wish to bring a poster presentation to the   Regulatory Determinants of Hematopoietic Stem Cell Self-Renewal, Lineage  

Commitment and Terminal Differentiation:  New Insights   should submit a concise one-page abstract summarizing their presentation no later than  

Wednesday, February 8, 2012.

POSTER PRESENTATIONS   will be displayed on 4-foot-high by 6-foot-wide poster boards. Pushpins and Velcro will be provided onsite. Please follow the   instructions below   to submit a poster abstract for consideration.  
  • The abstract must   not exceed 1 page   of text using 11-point type, single-spaced. The abstract text is limited to 500 words.
  • The poster abstract should include   a   title, all authors   (presenting author should be clearly underlined), department affiliation, university, city, state/province, country,   and   email address . Please acknowledge appropriate funding sources for your research.
  • Submit your abstract in   electronic format , preferably MS Word.Email the poster abstract no later than Wednesday, February 8, 2012, to Ms. Angela Meadows at ameadows@scgcorp.com.
Travel Awards and Selected Talks From Abstract Submissions
Students and postdoctoral researchers/fellows are encouraged to attend this workshop. A limited number of   travel awards   are available to workshop participants who submit abstracts selected for presentation as concise talks in the body of the workshop program. Presenters for short talks and travel award recipients will be chosen from among those who have submitted abstracts on the basis of special relevance of the abstract to the underlying themes of the Workshop. If you wish to be considered for a travel award and concise talk, please include a short cover letter containing a brief biographical sketch, along with your abstract.   The poster abstract submission deadline is
Wednesday, February 8, 2012.

Please send all abstract submissions to:   ameadows@scgcorp.com  

PowerPoint Presentations

All speakers should plan to send their   PowerPoint presentations   by email to   ameadows@scgcorp.com   no later than
Monday, February 13, 2012. All presentations will be loaded onto the workshop laptop. If you plan to use a MAC computer for your presentation, please note that information on your registration or send an email to Ms. Meadows. Both Mac and PC laptops will be available at the workshop.  


  • The American Institute of Architects
  • 1735 New York Avenue, NW
  • DC 20006