U.S. Department of Health and Human Services

Workshop on Developing Precision Medicine Approaches to the Treatment of Severe Obesity in Adolescents: Research Gaps and Opportunities

9/18/2017 12:00 AM
9/19/2017 12:00 AM
Yes
No

Program Contact

Voula Osganian, MD, ScD, MPH
Division of Digestive Diseases and Nutrition, NIDDK
T: 301-827-6939
E: voula.osganian@nih.gov

Meeting Registration

Email Lauren Meskill to register
E: MeskillL@extra.niddk.nih.gov

Rockville
 
Fishers Lane Conference Center

Event Details

Background

Severe obesity in adolescents is a growing and serious concern and is associated with significant physical and psychological co-morbidities. Response to behavioral and lifestyle interventions generally show relatively small improvements in BMI that are not sustained, and the limited pharmacotherapy options available also show modest efficacy. Bariatric surgery leads to the greatest and most sustained weight loss; however, it can be associated with considerable short and long term health risks, and despite surgical intervention, many adolescents continue to have severe obesity. Little is known regarding which treatment approaches will promote meaningful and sustained weight loss in adolescents with severe obesity or how to target such treatments to maximize efficacy.

Meeting Objectives

This workshop will bring together scientists with expertise in genetics, pediatric obesity, endocrinology, epidemiology, psychology, behavioral medicine, adolescent medicine, bariatric surgery, and other disciplines to discuss and identify 1) what is known regarding the epidemiology and biopsychosocial determinants of severe obesity in adolescents, 2) what is known regarding effectiveness of treatments for severe obesity in adolescents and predictors of response, and 3) gaps and opportunities for future research to develop more effective and targeted treatments for adolescents with severe obesity. The goal of this trans-NIH workshop is to accelerate research that will identify which treatment approaches will be most beneficial for specific patients based on a better understanding of individual differences in genetic endowment, clinical, metabolic, psychological, and behavioral phenotypes, and response to environmental exposures.

Organizing Committee

Chairs

Aaron S. Kelly, Ph.D.
Associate Professor of Pediatrics and Medicine
University of Minnesota Medical School
University of Minnesota Masonic Children's Hospital

Marsha D. Marcus, Ph.D.
Professor of Psychiatry and Psychology
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic

Jack A. Yanovski, M.D. Ph.D.
Chief of the Section on Growth and Obesity
Program on Developmental Endocrinology and Genetics
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health

NIH Members

NIDDK

Voula Osganian, M.D., Sc.D., M.P.H.
Andrew Bremer, M.D.
Mary Evans, Ph.D.
Christine Hunter, Ph.D., ABPP
Robert Kuczmarski, Dr.P.H.
Barbara Linder, M.D., Ph.D.
Pamela Thornton, Ph.D.
Susan Yanovski, M.D.

NICHD

Layla Esposito, Ph.D., M.A.

NHLBI

Charlotte Pratt, Ph.D., R.D.

OBSSR

Deborah Young-Hyman, Ph.D.

ODP

Rachel Ballad, M.D., M.P.H.

Registration Deadline

September 1, 2017 or until full.

To register, RSVP to Lauren Meskill via email with your name, affiliation and phone number.​​

Agenda

Monday, September 18, 2017

   
7:30 a.m. – 8:15 a.m. Registration
   
8:15 a.m. – 8:20 a.m. Welcoming Remarks
Griffin P. Rodgers, MD, MACP, National Institute of Diabetes and Digestive and Kidney Diseases
   
8:20 a.m. – 8:30 a.m. Introduction and Workshop Goals
Voula Osganian, MD, ScD, National Institute of Diabetes and Digestive and Kidney Diseases

Session I

Scope of the Problem: Severe Obesity and the Adolescent

Moderator: Robert Kuczmarski, PhD, National Institute of Diabetes and Digestive and Kidney Diseases
   
8:30 a.m. – 8:50 a.m. Epidemiology of Severe Obesity in Adolescents
Cynthia Ogden, PhD, Centers for Disease Control and Prevention
   
8:50 a.m. – 9:10 a.m. Adolescent Development
Margaret Zeller, PhD, Cincinnati Children's Hospital Medical Center
   
9:10 a.m. – 9:40 a.m. Question and Answer Panel
   
9:40 a.m. – 10:10 a.m. Break

Session II

Biopsychosocial and Behavioral Factors that are Associated with the Development of Severe Obesity in Adolescents

Moderator: Deborah Hyman-Young, PhD, Office of Behavioral and Social Sciences Research Office of the Director
   
10:10 a.m. – 10:35 a.m. Psychosocial, Behavioral and Environmental Risk Factors
Elissa Jelalian, PhD, Alpert Medical School of Brown University
   
10:35 a.m. – 11:00 a.m. Genetics and Epigenetics
Sadaf Farooqi, MBChB, PhD, University of Cambridge
   
11:00 a.m. – 11:25 a.m. Hedonic Eating, Food Reward and Appetite
Ania Jastreboff, MD, PhD, Yale University School of Medicine
   
11:25 a.m. – 11:55 a.m. Question and Answer Panel
   
11:55 a.m. – 12:45 p.m. Lunch

Session III

Treatment Approaches for Severe Obesity in Adolescents

Moderator: Charlotte Pratt, PhD, National Heart, Lung, and Blood Institute
   
12:45 p.m. – 1:05 p.m. Lifestyle and Behavioral Interventions
Marsha Marcus, PhD, University of Pittsburgh School of Medicine
   
1:05 p.m. – 1:25 p.m. POWER Clinical Registry- Clinical Experience and Health Outcomes
Shelley Kirk, PhD, RD, LD, Cincinnati Children's Hospital Medical Center
   
1:25 p.m. – 1:45 p.m. Pharmacologic Interventions
Aaron Kelly, PhD, University of Minnesota Medical School
   
1:45 p.m. – 2:05 p.m. Surgical Interventions
Thomas Inge, MD, PhD, Children's Hospital Colorado
   
2:05 p.m. – 2:25 p.m. Emerging Therapies
Lee Kaplan, MD, PhD, Harvard Medical School
   
2:25 p.m. – 2:45 p.m. Developing and testing a Chronic Care Model for the adolescent with severe obesity
Stephen Cook, MD, MPH, University of Rochester Medical Center
   
2:45 p.m. – 3:15 p.m. Question and Answer Panel
   
3:15 p.m. – 3:45 p.m. Break

Session IV

Biomarkers and Phenotypes that Predict Response to Treatment in Adolescents with Severe Obesity

Moderator: Barbara Linder, MD, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases
   
3:45 p.m. – 4:05 p.m. Eating Behaviors and Psychological Phenotypes/Factors
Kerri Boutelle, PhD, University of California, San Diego School of Medicine
   
4:05 p.m. – 4:25 p.m. Physical Activity Phenotypes/Factors
Molly Bray, PhD, RD, LD, The University of Texas at Austin
   
4:25 p.m. – 4:45 p.m. Biomarkers
Charles Burant, MD, PhD, University of Michigan
   
4:45 p.m. – 5:15 p.m. Question and Answer Panel
   
5:15 p.m. Closing Remarks Day 1 from Co-Chairs
   

Tuesday, September 19, 2017

   
8:00 a.m. – 8:15 a.m. Opening Remarks and Goals for Day 2
Voula Osganian, MD, ScD, National Institute of Diabetes and Digestive and Kidney Diseases
   
8:15 a.m. – 9:30 a.m. Breakout Sessions
  1. Epidemiology and Subgroups at Risk including Disparities and Special Populations

    Leader:  Cynthia Ogden, PhD, Centers for Disease Control and Prevention
    Facilitator:  Pamela Thornton, PhD, National Institute of Diabetes and Digestive and Kidney Diseases

  2. Biopsychosocial and Behavioral Factors Associated with the Development of Severe Obesity

    Leader:  Elissa Jelalian, PhD, Alpert Medical School of Brown University
    Facilitator:  Mary Evans, PhD, National Institute of Diabetes and Digestive and Kidney Diseases

  3. Treatment Approaches for Severe Obesity in Adolescents

    Leader:  Stephen Cook, MD, MPH, University of Rochester Medical Center
    Facilitator:  Barbara Linder, MD, PhD, National Institute of Diabetes and Digestive and Kidney Diseases

  4. Biomarkers and Phenotypes that Predict Response to Treatment

    Leader:  Charles Burant, MD, PhD, University of Michigan
    Facilitator:  Sue Yanovski, MD, National Institute of Diabetes and Digestive and Kidney Diseases
   
9:30 a.m. – 9:45 a.m. Break
   
9:45 a.m. – 10:45 a.m. Breakout Session Subgroup Presentations by Leaders (15 min each)
   
10:45 a.m. – 11:45 a.m. Full Group Panel Discussion led by Co-Chairs
   
11:45 a.m. – 12:15 p.m. Workshop Summary and Recommendations with Concluding Remarks from Co-Chairs
   
12:15 p.m. Wrap up and Adjournment
Voula Osganian, MD, ScD, National Institute of Diabetes and Digestive and Kidney Diseases
   

Directions/Travel

Hotel Accommodations

Hilton Washington DC/Rockville Hotel & Executive Meeting Center
1750 Rockville Pike
Rockville, MD  20852

Website:  http://www3.hilton.com/en/hotels/maryland/hilton-washington-dc-rockville-hotel-and-executive-meeting-ctr-IADMRHF/index.html
(More hotel information can be obtained from the website above. To make a hotel reservation, use the link under 'Government Room Rate' below.)

Government Room Rate

A limited block of sleeping rooms for meeting participants has been reserved at the Hilton Washington DC/Rockville Hotel & Executive Meeting Center. The rate is the prevailing government rate of $231 per night for single occupancy, plus tax (13%). To reserve a hotel room at the group rate, click on the link to book your group rate for the Workshop on Developing Precision Medicine Approaches to the Treatment of Severe Obesity in Adolescents: Research Gaps and Opportunities Meeting. The room block will be in effect at the Government rate only until Sunday, August 27, 2017, or until full, whichever comes first. Any room reservations received after this date will be accepted on a space and rate-availability basis.

Reservation Dates

Book arrival on Sunday, September 17, 2017, and departure on Tuesday, September 19, 2017. If you require alternate dates, please send an email to Lauren Meskill at MeskillL@extra.niddk.nih.gov. Any alternate date requests will need to be approved through the NIDDK.

Check-in

Please be certain that the hotel provides you with a confirmation number for your reservation. After August 27, 2017, the official room block will be released, and the hotel may charge significantly higher rates and may be sold out. When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 4:00 p.m., and checkout time is 12:00 p.m.

Cancellations

If you need to cancel your reservation, please do so by 4:00 p.m. on the day prior to arrival, or you will be charged a no-show fee for 1 night on your credit card.

NIH Visitor Information 

Information on visiting the NIH, campus maps, shuttle schedules, driving directions, security, and more can be found on the NIH Visitor Information page.​​​

Minutes

Minutes are currently unavailable.

Attendees

Attendees are currently unavailable.

Abstracts

Abstracts are currently unavailable.

Location

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  • 5635 Fishers Lane
  • Rooms 508/509
  • MD 20852
Webinar

Contacts

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Program Contact

Voula Osganian, MD, ScD, MPH
Division of Digestive Diseases and Nutrition, NIDDK
T: 301-827-6939
E: voula.osganian@nih.gov

Meeting Registration

Email Lauren Meskill to register
E: MeskillL@extra.niddk.nih.gov