The Adipose Tissue Niche: Role in Health and Diseases

Event Details

Background

The National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focusing on the role of the adipose tissue niche in the development, maintenance and remodeling of different adipose tissue depots in healthy individuals, and how the extracellular matrix and cellular components of the niche are modified during the develop of diabetes, in the overfed state, and following other metabolic stressors. Speakers will address basic mechanisms, clinical issues and potential new concepts for treatment.

Plenary talks, selected “hot topic” presentations, and a poster session will provide a forum for interactions among basic adipocyte biologists and physiologists, stem cell biologists, bioengineers, and clinical scientists, as well as both established and new investigators in the field.

Meeting Objectives

The scientific focus of this meeting will be on the following topics:

• Adipose Tissue Remodeling and Fibrosis
• Adipose Tissue Support Cells:  Role of Pericytes, Vascular Smooth Muscle Cells, Stem Cells and Other Stromal Cells
• Depot Specific Extracellular Matrix Components and Mechano-transduction
• Building Fat for Soft Tissue Reconstruction
• Building Fat Depots on a Chip

Organizing Committee

Dr. Stephen Farmer
Dr. Carol Haft
Dr. Kevin Healy
Dr. Valarie Horsley

Sponsors

The National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, and the U.S. Department of Health and Human Services

Registration Deadline

November 10, 2016

There is no registration fee to attend. However, registration is required. Seating is limited to the first 170 people registered.

Agenda

Agenda (PDF, 423.65 KB)

November 29, 2016

7:30 a.m. – 8:15 a.m.

Registration
(Lister Hill Auditorium, NIH Campus)

8:15 a.m. – 8:30 a.m.

Opening Remarks/Meeting Overview

8:30 a.m. – 9:15 a.m.

Keynote 1: Perivascular Cells, Plasticity and Organ Fibrosis
Benjamin Humphreys, M.D. Ph.D., Washington University

9:15 a.m. – 10:00 a.m.

Keynote 2: Cells and Viscoelasticity
David J. Mooney, Ph.D., Harvard University

10:00 a.m. – 10:30 a.m.

Break

Session I: Adipose Tissue Remodeling and Fibrosis

Moderator: Valerie Horsley

10:30 a.m. – 11:00 a.m.

Adipogenic Signaling in Scleroderma Fibrosis: Potential Clinical Implications
John Varga, M.D., Northwestern University

11:00 a.m. – 11:30 a.m.

Adipose Tissue Fibrosis: Progenitors Contribution
Karine Clement, M.D., Ph.D., Institute of Cardio-metabolism and Nutrition, Paris

11:30 a.m. – 11:45 a.m.

Hot Topic—Ubiquitin Ligase Siah2 in Adipocytes Regulated Obesity-Induced Macrophage Recruitment in Adipose Tissue
Elizabeth Floyd, Ph.D., Pennington Biomedical Research Center

11:45 a.m. – 12:15 p.m.

Myocardin Related Transcription Factor A Regulates Healthy and Unhealthy Remodeling of White Adipose Tissue
Stephen Farmer, Ph.D., Boston University School of Medicine

12:15 p.m. – 12:30 p.m.

Poster Blitz #1
Boards #s 3,4,6,10,12,16,20,21,22,23

12:30 p.m. – 2:00 p.m.

Poster Session and Lunch in Atrium

Session II: Adipose Tissue Support Cells: Role of Pericytes, Vascular Smooth Muscle Cells, Stem Cells and Other Stromal Cells

Moderator: Stephen Farmer

2:00 p.m. – 2:30 p.m.

Contribution of Mural Cells to Adipose Tissue Remodeling
Rana Gupta, Ph.D., UT Southwestern University

2:30 p.m. – 3:00 p.m.

Nutrient-Sensing Signaling Mechanisms that Control Adipocyte Expansion and Function
David Guertin, Ph.D., University of Massachusetts Medical School, Worcester

3:00 p.m. – 3:15 p.m.

Hot Topic—Adipose Tissue Macrophages and Preadipocytes as Mediators and Predictors of Adipose Tissue Remodeling with Weight Loss
Carey Lumeng, M.D., Ph.D., University of Michigan Medical School

3:15 p.m. – 3:45 p.m.

Mature Adipocytes Contribute to Skin Wound Healing
Valerie Horsley, Ph.D., Yale University

3:45 p.m. – 4:15 p.m.

Break

4:15 p.m. – 4:45 p.m.

Transcellular and Inter-Organ Trafficking of Adipose Tissue-Derived Particles
Clair Crewe, Ph.D., UT Southwestern University

4:45 p.m. – 5:00 p.m.

Hot Topic—Trans-endothelial and Adipocyte Transport of Fatty Acids in White Adipose Tissue is Regulated by Prohibitin/Annexin 2 Interactions
Alexes Daquinag,Ph.D., University of Texas Health Science Center, Houston

5:00 p.m. – 5:15 p.m.

Hot Topic—Transcription Factor Dynamics Define a Circadian Code for Fat Cell Differentiation
Mary Teruel, Ph.D.,Stanford University

5:30 p.m.

Adjourn

November 30, 2016

7:30 a.m. – 8:00 a.m.

Registration
(Lister Hill Auditorium, NIH Campus)

Session III: Depot Specific Extracellular Matrix Components and Mechano-transduction

Moderator: Kevin Healy

8:00 a.m. – 8:30 a.m.

Extracellular Matrix Control of Adipocyte Progenitor Differentiation and Fibrosis
Matthew Layne, Ph.D., Boston University School of Medicine

8:30 a.m. – 9:00 a.m.

Heat and Tension in the Adipose Niche
Andreas Stahl, Ph.D., University of California, Berkeley

9:00 a.m. – 9:15 a.m.

Hot Topic—A Glucocorticoid and Diet-Responsive Signal in the Adipose Niche Cates the Initiation of Adipogenesis
Brian Feldman, M.D, Ph.D., Stanford University School of Medicine

9:15 a.m. – 9:45 a.m.

Pericellular Collagenolysis and the Regulation of the Adipocyte Transcriptome
Stephen Weiss, M.D., University of Michigan

9:45 a.m. – 10:15 a.m.

Break

Session IV: Building Fat for Soft Tissue Reconstruction

Moderator: Bruce Bunnell

10:15 a.m. – 10:45 a.m.

Tissue Engineered Humanized “Fat on a Chip” Utilizing Adipose Tissue-Derived Stromal Vascular Fraction
Trivia Frazier, Ph.D., Tulane University and LaCell, LLC., New Orleans

10:45 a.m. – 11:15 a.m.

Adipose Derived Stromal Cells for Soft and Hard Tissues: Perspective of a Cranial Facial Surgeon
Michael Longaker, M.D., Stanford University School of Medicine

11:15 a.m. – 11:45 p.m.

Our hASC History: Tissue Engineering, Donor-to-Donor Differences, and Translating Textiles to Tissues
Elizabeth Loboa, Ph.D., University of Missouri

11:45 p.m. – 12:00 p.m.

Hot Topic—Imaging Adipose Tissue Across Scales of Resolution from Two-Photon to Super-Resolution Microscopy
Daniela Malide, M.D., Ph.D., National Institute of Heart, Lung and Blood, NIH

12:00 p.m. – 12:15 p.m.

Poster Blitz #2
Boards #s 24,28,29,32,34,35,37,38,40,45

12:15 p.m. – 1:30 p.m.

Poster Session and Lunch

Session V: Building Fat Depots on a Chip

Moderator: Andreas Stahl

1:30 p.m. – 2:00 p.m.

Vascularizing Fat on a Chip
Leah Bellas, Ph.D., Boston University

2:00 p.m. – 2:30 p.m.

Microengineered Physiological Biomimicry: Human Organs-on-a-Chips
Daniel Huh, Ph.D., University of Pennsylvania

2:30 p.m. – 2:45 p.m.

Hot Topic—A Complex Co-culture White Adipose Tissue Model for Predicting Therapeutic Responses
Rosalyn Abbott, Ph.D., Tufts University

2:45 p.m. – 3:15 p.m.

Bone Marrow Adipose: Tissue Engineered and in vivo Models
Michaela Reagan, Ph.D., Maine Medical Center Research Institute

3:15 p.m. – 3:45 p.m.

WAT-on-a-Chip: A Physiologically Relevant Microfluidic System Incorporating White Adipose Tissue
Kevin Healy, Ph.D., University of California, Berkeley

3:45 p.m. – 4:00 p.m.

Closing Remarks

4:00 p.m.

Adjournment