Event Details
Agenda
Event Details
Background
In 1999, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) convened a workshop, Women in Renal Disease, that focused on identifying the unique risks of Chronic Kidney Disease (CKD) and progression to end-stage renal disease present in women across their lifespans. At the conclusion of the workshop, the workshop organizers proposed several avenues of research to advance our understanding of the pathophysiology of sex differences in CKD and improve clinical care of women with CKD. While some advances have been made in both clinical and basic research, much remains poorly understood, both at the molecular and clinical level.
Meeting Objectives
The NIH has recently re-focused the investigator community on the role of sex as a biological variable—requiring all research grant submissions to deliberately consider sex as a modifier of biological response. The purpose of this workshop is to afford the renal research community an opportunity to re-visit the role of sex in disease risk and etiology and take advantage of the advances made in our understanding of sex steroid action in somatic tissues, as well as understanding the role of sex chromosome complement in disease pathophysiology.
Organizing Committee
Dr. Paul Kimmel, NIDDK/NIH
Dr. Tracy Rankin, NIDDK/NIH
Dr. Ken Korach, NIEHS/NIH
Dr. Louis DePaolo, NICHD/NIH
Dr. Lisa Begg, ORWH/NIH
Dr. Sharon Anderson, Oregon Health Sciences University
Dr. Kathryn Sandberg, Georgetown University
Dr. Jennifer C. Sullivan, Georgia Regents University
Dr. Julie Ingelfinger, Harvard University
Registration Deadline
July 07, 2017
Agenda
July 13, 2017
- 7:00 – 8:00 a.m.
- Registration
- 8:00 – 8:15 a.m.
- Opening Remarks and Objectives—Auditorium
Session 1: Molecular Endocrinology of Sex Steroid Action
Moderator: Tracy Rankin, Ph.D., NIDDK
- 8:15 – 10:20 a.m.
- Introduction
Tracy Rankin, Ph.D., NIDDK
- Current Understanding and Unknowns in Estrogen Action
Kenneth Korach, Ph.D., National Institute of Environmental Health Sciences
- Current Understanding and Unknowns in Androgen Action
Stephen Hammes, M.D., Ph.D., University of Rochester Medical Center
- Therapeutic Modulators of Estrogen and Androgen Actions
Carolyn Smith, Ph.D., Baylor College of Medicine
- Role of Sex Chromosomes in Sex Differences
Christine Disteche, Ph.D., University of Washington
- 10:20 – 10:40 a.m.
- Break
Session 2: Biology and Epidemiology of Sex Differences—Lessons from other Systems—Auditorium
Moderator: Julie Ingelfinger, M.D., MassGeneral Hospital for Children (tentative)
- 10:40 – 12:40 p.m.
- Cardiovascular Disease and Bone Health
C. Noel Bairey Merz, M.D., FACC, Cedars-Sinai Medical Center
- Diabetes and Obesity
Franck Mauvais-Jarvis, M.D., Ph.D., Tulane University School of Medicine
- Interactions with Race/Ethnicity
Ana Ricardo, M.D., M.P.H., M.S., University of Illinois College of Medicine at Chicago
- Microbiome and Sex Differences
James Morton, Ph.D., University of California, San Diego
- 12:40 – 1:40 p.m.
- Lunch
Breakout Sessions
- 1:40 – 3:50 p.m.
- Session 1: Basic Science Needs—Balcony A
Session Leaders: Tracy Rankin, Ph.D., NIDDK
Jennifer Sullivan, Ph.D., FAHA, Augusta University
- Session 2: Translational Approaches—Balcony B
Session Leaders: Julie Ingelfinger, M.D., Massachusetts General Hospital
Christine Maric-Bilkan, Ph.D., National Heart, Lung, and Blood Institute
- Session 3: Needed Methods/Tools—Balcony C
Session Leader: Kathryn Sandberg, Ph.D., Georgetown University Medical Center
- Session 4: Clinical Research Needs/Approaches—Auditorium
Session Leader: Laura Dember, M.D., University of Pennsylvania
- 3:50 – 4:10 p.m.
- Break
Breakout Sessions—Reports and Group Discussion—Auditorium
Breakout Sessions Reports
- 4:10 – 4:30 p.m.
- Breakout Session 1
- 4:30 – 4:50 p.m.
- Breakout Session 2
- 4:50 – 5:10 p.m.
- Breakout Session 3
- 5:10 – 5:30 p.m.
- Breakout Session 4
- 5:30 – 6:00 p.m.
- Cross-Arching Group Discussion
- 6:00 p.m.
- Day 1 Adjournment
July 14, 2017
- 8:00 – 8:30 a.m.
- Registration
Session 3: Renal Disease: Basic Mechanisms and Clinical Manifestation—Auditorium
Moderator: Paul Kimmel, M.D., M.A.C.P., NIDDK
- 8:30 – 10:30 a.m.
- Cellular Aspects
James Fuscoe, Ph.D., U.S. Food and Drug Administration
- Clinical Aspects
Joel Neugarten M.D., J.D., Albert Einstein College of Medicine
- Sex Differences in Transplantation Outcomes
Amanda Miller, M.D., Dalhousie University
- Women and Hypertension
Vesna Garovic, M.D., Mayo Clinic
- 10:30 – 10:45 a.m.
- Break
Session 4: Approaches and Tools to Interrogate and Treat Sex Differences—Auditorium
Moderator: Kathryn Sandberg, Ph.D., Georgetown University Medical Center
- 10:45 – 12:00 p.m.
- Design of Pre-Clinical Studies to Account for Sex Differences
Janine Clayton, M.D., Director, Office of Research on Women’s Health, NIH
- Novel Renal Imaging Modalities
Jennifer Charlton, M.D., University of Virginia School of Medicine
- Precision Medicine Approaches to Design Sex-Specific Therapies
Virginia Miller, Ph.D., Mayo Clinic
- 12:00 – 1:00 p.m.
- Lunch
Breakout Sessions
- 1:00 – 2:40 p.m.
- Session 1: Basic Science Needs—Balcony A
Session Leader(s): Tracy Rankin, Ph.D., NIDDK
Jennifer Sullivan, Ph.D., FAHA, Augusta University
- Session 2: Translational Approaches—Balcony B
Session Leader(s): Julie Ingelfinger, M.D., Massachusetts General Hospital
Christine Maric-Bilkan, Ph.D., National Heart, Lung, and Blood Institute
- Session 3: Needed Methods/Tools—Balcony C
Session Leader: Kathryn Sandberg, Ph.D., Georgetown University Medical Center
- Session 4: Clinical Research Needs/Approaches—Auditorium
Session Leader: Laura Dember, M.D., University of Pennsylvania
- 2:40 – 3:00 p.m.
- Break
Breakout Sessions—Reports and Group Discussion—Auditorium
Breakout Sessions Reports
- 3:00 – 3:20 p.m.
- Breakout Session 1
- 3:20 – 3:40 p.m.
- Breakout Session 2
- 3:40 – 4:00 p.m.
- Breakout Session 3
- 4:00 – 4:20 p.m.
- Breakout Session 4
- 4:20 – 4:30 p.m.
- Cross-Arching Group Discussion and Closing Remarks—Auditorium
- 4:30 p.m.
- Adjournment
