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NIDDK Grantee News

Aug 1, 2016

[Medical College of Wisconsin; Case Western Reserve University] Researchers tested whether abnormal autonomic nervous system innervation of the bladder underlies IC (interstitial cystitis)/BPS (bladder pain syndrome) differently than other chronic pelvic pain. Some chronic pelvic pain types showed autonomic neuropathy and some show vagal withdrawal.

NIDDK Grantee News

Jul 11, 2016

[Oregon Health and Science University; University of Pennsylvania School of Medicine] Human pancreatic islets of Langerhans contain five distinct endocrine cell types, each producing a characteristic hormone. The dysfunction or loss of the insulin-producing β cells causes diabetes mellitus, a disease that harms millions. Until now, β cells were generally regarded as a single, homogenous cell population.

NIDDK Grantee News

Jun 15, 2016

[New York University Langone Medical Center] The intestinal “microbiota,” that is, the community of microbes inhabiting the human intestinal tract, undergoes many changes during the first 2 years of life. Bokulich et al. now show that this pattern of development is altered in children who are delivered by cesarean section, fed formula, or treated with antibiotics, compared to those babies who were born vaginally, breast-fed, or unexposed to antibiotics.

NIDDK Grantee News

Jun 8, 2016

[Yale University School of Medicine] Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae.

NIDDK Grantee News

Jun 7, 2016

[Colorado School of Public Health; University of Colorado School of Medicine] Poor maternal diet in pregnancy can influence fetal growth and development. We tested the hypothesis that poor maternal diet quality during pregnancy would increase neonatal adiposity (percent fat mass [%FM]) at birth by increasing the FM component of neonatal body composition.

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