Adult-to-Adult Living Donor Liver Donor Liver Transplantation Cohort Study

Acronym: A2ALL NIDDK Contact: Averell Sherker Principal Investigator(s): Not Available


This study supports nine liver transplant centers with expertise in adult living-donor liver transplantation (LDLT) and a central data coordinating center. The major aims of A2ALL are as follows:

  • quantify the impact of choosing LDLT on the candidate for transplantation
  • characterize the difference between LDLT and deceased donor liver transplant (DDLT) in terms of post-transplant outcomes, including patient and graft survival, surgical morbidity, and resource utilization on the recipient of a transplant  
  • determine the short- and long-term health and quality of life (QOL) impact of donation, including (a) morbidity after liver donation and (b) long-term health-related QOL of donors
  • standardize and assess the role of "informed consent" in affecting the decision to donate and satisfaction after living liver donation
  • other aims include comparison of the severity of recurrence of hepatocellular carcinoma for DDLT versus LDLT, the systematic characterization of liver regeneration and function in donors and recipients, the evaluation of the differences in the immune response to LDLT versus DDLT, and the establishment of a robust data and sample repository on liver transplantation that may be used to study clinical and biological questions as new technologies and resources become available

Patients enrolled in the study will be followed and managed in a standardized fashion.

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