S1pr2 KO Mouse

Acronym: Mutant Mouse: S1pr2 NIDDK Contact: Principal Investigator(s): Richard Proia


A Spingosine-1-phosphate Receptor-2 (S1pr2) knockout mouse.

Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, activates cell signaling by interacting with a family of G-protein-coupled cell-surface S1P receptors that activate different and overlapping signaling pathways.  Three S1P receptors (S1P1, S1P2 and S1P3) are abundant in embryonic endothelial cells.  S1P1 knockouts are embryonic lethals because of hemorrhage.  S1P2 null mice did not exhibit embryonic lethality or phenotypic abnormalities.  However, double null embryos (S1P1 S1P2 and S1P2 S1P3), and triple null embryos (S1P1 S1P2 S1P3) displayed a more severe vascular phenotype than did S1P1 null embryos, suggesting cooperative functions of the three S1P receptors.

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