S1pr3 KO Mouse

Acronym: Mutant Mouse: s1pr3 NIDDK Contact: Principal Investigator(s): Richard Proia


A Spingosine-1-phosphate Receptor-3 (S1pr3) knockout mouse.

Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, activates cell signaling by interacting with a family of G-protein-coupled cell-surface S1P receptors that activate different and overlapping signaling pathways.  Three S1P receptors (S1P1, S1P2 and S1P3) are abundant in embryonic endothelial cells.  SIP1 knockouts are embryonic lethals because of hemorrhage, but neither S1P2 null mice nor S1P3 null mice were embryonic lethals.  Double null embryos (S1P2 S1P3) and triple null embryos (S1P1 S1P2 S1P3), however, displayed a more severe vascular phenotype than did S1P1 null embryos, suggesting that S1P2 and S1P3 receptors act cooperatively.

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