U.S. Department of Health and Human Services

Carbohydrates Section

Paul Kovac, Ph.D., Dr. h.c., Chief

​Research Images

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TitleDescriptionImage
Hexasaccharide conjugate (Hexa-rTT-Hc)Conjugate construct (vaccine) made from the Antigen and Carrier by squaric acid chemistry of conjugation, utilizing the sole amino group in the Spacer and amino group in the L-lysine residues present in the carrier.Hexasaccharide conjugate (Hexa-rTT-Hc)Enlarge
Multivalent conjugate (Multivalent)Bivalent conjugate construct (vaccine) made from Antigens A and B and Carrier by squaric acid chemistry of conjugation, utilizing the sole amino group in each Spacer and amino group in the L-lysine residues present in the carrier.Multivalent conjugate (Multivalent)Enlarge
O-PS-core-rTT-Hc conjugate (O-PS-core-rTT-Hc)Conjugate construct (vaccine) made from the Antigen and Carrier by squaric acid chemistry of conjugation, utilizing the sole amino group of D-glucosamine in the core and amino group in the L-lysine residues present in the carrier.O-PS-core-rTT-Hc conjugate (O-PS-core-rTT-Hc)Enlarge
Model of the monoclonal anti Vibrio cholerae O1, serotype Ogawa antibody–O-SP complexThis image depicts a model based on the X-ray structure of the Fab crystalline complex, with synthetic disaccharide that mimics terminus of bacterial O-PS. Individual perosamine residues (various colors) are shown along with the light (light blue) and heavy chains (dark blue) of the Ab-variable domains, and the 2-O-methyl group-interface center (yellow). Disaccharide synthesis from Section on Carbohydrates, LBC; crystallography performed at Institute Pasterur, Paris, France; taken from Villeneuve et al., PNAS, Vol. 97 (2000) 8433–8438Model of the monoclonal anti Vibrio cholerae O1, serotype Ogawa antibody–O-SP complexEnlarge