U.S. Department of Health and Human Services

Laboratory of Biochemistry and Genetics

Reed B. Wickner, M.D., NIH Distinguished Investigator, Chief

​About the Lab/Branch

The Laboratory of Biochemistry and Genetics uses molecular genetics, biochemical techniques, and physical chemical approaches, to study a diverse range of topics related to disease and health. These include: prions (infectious proteins) in yeast; the roles of chaperones and other components in yeast prions; centrosome replication and function; gamete development, meiosis, and fertilization; molecular crowding; biosynthesis of polyamines and their roles in translation and other functions; and  bacterial pathogenesis and antibiotic r​esistance in ulcer disease.​​​

​Current Research

Our goal is to discover new knowledge useful in understanding basic biology and disease processes.

Understanding the mechanisms of yeast infectious diseases, including prions, mechanisms of early development and of centrosome duplication, chaperone action on pathologic aggregates, polyamine action and molecular crowding will facilitate understanding of similar processes which play a role in many human diseases.?