U.S. Department of Health and Human Services

Laboratory of Biological Modeling

Arthur Sherman, Ph.D., Chief

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Food, Energy, and Obesity - Kevin Hall, NIH Physicist

Kevin Hall, Ph.D., applies a physicist's view of energy to the human body at the National Institutes of Health (NIH) Intramural Research Program (IRP). Dr. Hall is a Senior Investigator in the Laboratory of Biological Modeling at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Pancreatic Beta Cell Signaling PathwaysThis schematic provides an illustration of some of the pathways included in our models. See Sherman, Mathematical Biosci. 227:12-19, 2007 for details.Pancreatic Beta Cell Signaling PathwaysEnlarge
Sliding barsThis schematic model depicts changes in islet activity due to step increases in glucose concentration. A sliding threshold representation of the dual oscillator model dynamics is depicted left, with measured islet Ca2+ concentration and corresponding model simulations, right. The models are from Bertram et al, Am. J. Physiol. Endocrinol. Metab. 293:890-900.Sliding barsEnlarge