U.S. Department of Health and Human Services

Gene Regulation and Development Section

Ann Dean, Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Krivega I, Dean A. A tetrad of chromatin interactions for chromosome pairing in X inactivation. Nat Struct Mol Biol. 2017 Aug 3; 24 (8; 2017 Aug 3; 24):607-608. [Full Text/Abstract]
Krivega I, Dean A. CTCF fences make good neighbours. Nat Cell Biol. 2017 Jul 28; 19 (2017 Jul 28; 8; 19):883-885. [Full Text/Abstract]
Lee J, Krivega I, Dale RK, Dean A. The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions. Cell Rep. 2017 Jun 20; 19 (19; 2017 Jun 20; 12):2490-2502. [Full Text/Abstract]
Krivega I, Dean A. LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Nucleic Acids Res. 2017 May 18; 45 (2017 May 18; 14; 45):8255-8268. [Full Text/Abstract]
Krivega I, Dean A. Chromatin looping as a target for altering erythroid gene expression. Ann N Y Acad Sci. 2016 Feb 25; 1368 (1368; 2016 Feb 25; 1):31-9. [Full Text/Abstract]
Krivega I, Byrnes C, de Vasconcellos JF, Lee YT, Kaushal M, Dean A, Miller JL. Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping. Blood. 2015 May 15; 126 (126; 2015 May 15; 5):665-72. [Full Text/Abstract]
Krivega I, Dean A. Chromosome togetherness at the onset of ESC differentiation. Cell Stem Cell. 2015 Mar 5; 16 (16; 2015 Mar 5; 3):213-4. [Full Text/Abstract]
Deng W, Rupon JW, Krivega I, Breda L, Motta I, Jahn KS, Reik A, Gregory PD, Rivella S, Dean A, Blobel GA. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 2014 Aug 14; 158 (2014 Aug 14; 4; 158):849-860. [Full Text/Abstract]
Plank JL, Dean A. Enhancer function: mechanistic and genome-wide insights come together. Mol Cell. 2014 Jul 3; 55 (55; 1; 2014 Jul 3):5-14. [Full Text/Abstract]
Krivega I, Dale RK, Dean A. Role of LDB1 in the transition from chromatin looping to transcription activation. Genes Dev. 2014 Jun 15; 28 (28; 2014 Jun 15; 12):1278-90. [Full Text/Abstract]
Yun WJ, Kim YW, Kang Y, Lee J, Dean A, Kim A. The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription. Nucleic Acids Res. 2014 Apr; 42 (7; 42; 2014 Apr):4283-93. [Full Text/Abstract]
Li L, Freudenberg J, Cui K, Dale R, Song SH, Dean A, Zhao K, Jothi R, Love PE. Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood. 2013 May 30; 121 (2013 May 30; 121; 22):4575-85. [Full Text/Abstract]
Pennacchio LA, Bickmore W, Dean A, Nobrega MA, Bejerano G. Enhancers: five essential questions. Nat Rev Genet. 2013 Apr; 14 (14; 4; 2013 Apr):288-95. [Full Text/Abstract]
Junier I, Dale RK, Hou C, Képès F, Dean A. CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus. Nucleic Acids Res. 2012 Sep; 40 (40; 2012 Sep; 16):7718-27. [Full Text/Abstract]
Deng W, Lee J, Wang H, Miller J, Reik A, Gregory PD, Dean A, Blobel GA. Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell. 2012 Jun 8; 149 (149; 6; 2012 Jun 8):1233-44. [Full Text/Abstract]
Bender MA, Ragoczy T, Lee J, Byron R, Telling A, Dean A, Groudine M. The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation. Blood. 2012 Apr 19; 119 (16; 119; 2012 Apr 19):3820-7. [Full Text/Abstract]
Krivega I, Dean A. Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev. 2012 Apr; 22 (2; 2012 Apr; 22):79-85. [Full Text/Abstract]
Kiefer CM, Lee J, Hou C, Dale RK, Lee YT, Meier ER, Miller JL, Dean A. Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood. 2011 Dec 1; 118 (118; 23; 2011 Dec 1):6200-8. [Full Text/Abstract]
Krivega M, Dean A. Insulators organize chromatin: emerging rules of the game. Mol Cell. 2011 Oct 7; 44 (2011 Oct 7; 44; 1):1-2. [Full Text/Abstract]
Lienert F, Wirbelauer C, Som I, Dean A, Mohn F, Schübeler D. Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet. 2011 Oct 2; 43 (2011 Oct 2; 43; 11):1091-7. [Full Text/Abstract]
Li L, Lee JY, Gross J, Song SH, Dean A, Love PE. A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med. 2010 Nov 22; 207 (207; 12; 2010 Nov 22):2543-50. [Full Text/Abstract]
Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, Dean A. Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood. 2010 Sep 30; 116 (116; 13; 2010 Sep 30):2356-64. [Full Text/Abstract]
Hou C, Dale R, Dean A. Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proc Natl Acad Sci U S A. 2010 Feb 23; 107 (107; 8; 2010 Feb 23):3651-6. [Full Text/Abstract]
Kim SI, Bultman SJ, Kiefer CM, Dean A, Bresnick EH. BRG1 requirement for long-range interaction of a locus control region with a downstream promoter. Proc Natl Acad Sci U S A. 2009 Feb 17; 106 (106; 7; 2009 Feb 17):2259-64. [Full Text/Abstract]
Hou C, Zhao H, Tanimoto K, Dean A. CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A. 2008 Dec 23; 105 (105; 2008 Dec 23; 51):20398-403. [Full Text/Abstract]
Song SH, Hou C, Dean A. A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell. 2007 Dec 14; 28 (28; 2007 Dec 14; 5):810-22. [Full Text/Abstract]