U.S. Department of Health and Human Services

Gene Regulation and Development Section

Ann Dean, Ph.D., Chief

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Lab members 2017

(Left to right) Guoyou Liu, Luis Diaz, Xiang Guo, Ben Leadem, Maria Soledad Ivaldi, Ivan Krivega, Dr. Dean, Jun Zhang

(Left to right) Guoyou Liu, Luis Diaz, Xiang Guo, Ben Leadem, Maria Soledad Ivaldi, Ivan Krivega, Dr. Dean, Jun ZhangEnlarge
A working model of the relationship between chromatin looping and transcription activation in the β-globin locus

In erythroid cells, the β-globin LCR and gene are occupied by the Ldb1/LMO2/TAL1/GATA-1 complex, and Ldb1 dimerization is the basis of loop formation (Song, et al., Molecular Cell, 2007; Deng et al., Cell, 2012). The locus moves from the nuclear periphery to the interior for robust transcription of the gene in transcription factories (Song et al., Blood, 2010). (A) Looping could be promoted by pol II density and by transcription in a factory. (B) Alternatively, looping might be facilitated by a cell-type specific chromosomal organization that is stabilized by Ldb1 dimerization (reviewed in Krivega and Dean, Current Opinion in Genetics & Development, 2012). Mutational analysis of Ldb1 favors the latter model (I. Krivega and A. Dean, Genes and Development, 2014).

A working model of the relationship between chromatin looping and transcription activation in the β-globin locusEnlarge