U.S. Department of Health and Human Services

Mammalian Developmental Biology Section

Jurrien Dean, M.D., Chief


A selection of recent and significant publications can be viewed below.

Tokuhiro K, Dean J. Glycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy. Dev Cell. 2018 Aug 13; 46 (46; 2018 Aug 13; 5):627-640.e5. [Full Text/Abstract]
Shin SW, Vogt EJ, Jimenez-Movilla M, Baibakov B, Dean J. Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21; 8 (2017 Nov 21; 8; 1):1643. [Full Text/Abstract]
Zhou L, Canagarajah B, Zhao Y, Baibakov B, Tokuhiro K, Maric D, Dean J. BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice. Dev Cell. 2017 Mar 13; 40 (40; 5; 2017 Mar 13):453-466.e5. [Full Text/Abstract]
Xiong B, Zhao Y, Beall S, Sadusky AB, Dean J. A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice. PLoS Genet. 2017 Jan 23; 13 (2017 Jan 23; 13; 1):e1006580. [Full Text/Abstract]
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos. Development. 2016 Dec 19; 144 (2016 Dec 19; 144; 3):519-528. [Full Text/Abstract]
Wu D, Dean J. BTG4, a maternal mRNA cleaner. J Mol Cell Biol. 2016 Jun 23; 8 (8; 2016 Jun 23; 4):369-70. [Full Text/Abstract]
Avella MA, Baibakov BA, Jimenez-Movilla M, Sadusky AB, Dean J. ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception. Sci Transl Med. 2016 Apr 27; 8 (8; 2016 Apr 27; 336):336ra60. [Full Text/Abstract]
Dean J. Exacting Requirements for Development of the Egg. N Engl J Med. 2016 Jan 21; 374 (374; 2016 Jan 21; 3):279-80. [Full Text/Abstract]
Zhou LQ, Dean J. Reprogramming the genome to totipotency in mouse embryos. Trends Cell Biol. 2014 Oct 21; 25 (25; 2; 2014 Oct 21):82-91. [Full Text/Abstract]
Yu XJ, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang ZB, Zheng P, Zhu MS, Wang H, Sun QY, Dean J, Li L. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nat Commun. 2014 Sep 11; 5 (2014 Sep 11; 5):4887. [Full Text/Abstract]
Avella MA, Baibakov B, Dean J. A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. J Cell Biol. 2014 Jun 23; 205 (2014 Jun 23; 6; 205):801-9. [Full Text/Abstract]
Avella MA, Xiong B, Dean J. The molecular basis of gamete recognition in mice and humans. Mol Hum Reprod. 2013 May; 19 (2013 May; 19; 5):279-89. [Full Text/Abstract]
Baibakov B, Boggs NA, Yauger B, Baibakov G, Dean J. Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice. J Cell Biol. 2012 Jun 25; 197 (2012 Jun 25; 197; 7):897-905. [Full Text/Abstract]
Burkart AD, Xiong B, Baibakov B, Jiménez-Movilla M, Dean J. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012 Apr 2; 197 (197; 2012 Apr 2; 1):37-44. [Full Text/Abstract]
Avella MA, Dean J. Fertilization with acrosome-reacted mouse sperm: implications for the site of exocytosis. Proc Natl Acad Sci U S A. 2011 Dec 13; 108 (108; 50; 2011 Dec 13):19843-4. [Full Text/Abstract]
Jimenez-Movilla M, Dean J. ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida. J Cell Sci. 2011 Mar 15; 124 (124; Pt 6; 2011 Mar 15):940-50. [Full Text/Abstract]
Yauger B, Boggs NA, Dean J. Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice. Reproduction. 2011 Mar; 141 (2011 Mar; 141; 3):313-9. [Full Text/Abstract]
Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science. 2010 Jul 9; 329 (329; 5988; 2010 Jul 9):216-9. [Full Text/Abstract]
Hu W, Gauthier L, Baibakov B, Jimenez-Movilla M, Dean J. FIGLA, a basic helix-loop-helix transcription factor, balances sexually dimorphic gene expression in postnatal oocytes. Mol Cell Biol. 2010 Jul; 30 (30; 14; 2010 Jul):3661-71. [Full Text/Abstract]
Zheng P, Dean J. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5; 106 (106; 2009 May 5; 18):7473-8. [Full Text/Abstract]
Li L, Baibakov B, Dean J. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell. 2008 Sep; 15 (15; 3; 2008 Sep):416-25. [Full Text/Abstract]
Ohsugi M, Zheng P, Baibakov B, Li L, Dean J. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan; 135 (2008 Jan; 2; 135):259-69. [Full Text/Abstract]
Baibakov B, Gauthier L, Talbot P, Rankin TL, Dean J. Sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosis. Development. 2007 Mar; 134 (134; 5; 2007 Mar):933-43. [Full Text/Abstract]
Hoodbhoy T, Avilés M, Baibakov B, Epifano O, Jiménez-Movilla M, Gauthier L, Dean J. ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida. Mol Cell Biol. 2006 Nov; 26 (21; 26; 2006 Nov):7991-8. [Full Text/Abstract]
Hoodbhoy T, Joshi S, Boja ES, Williams SA, Stanley P, Dean J. Human sperm do not bind to rat zonae pellucidae despite the presence of four homologous glycoproteins. J Biol Chem. 2005 Apr 1; 280 (280; 13; 2005 Apr 1):12721-31. [Full Text/Abstract]
Zhao M, Gold L, Dorward H, Liang LF, Hoodbhoy T, Boja E, Fales HM, Dean J. Mutation of a conserved hydrophobic patch prevents incorporation of ZP3 into the zona pellucida surrounding mouse eggs. Mol Cell Biol. 2003 Dec; 23 (2003 Dec; 23; 24):8982-91. [Full Text/Abstract]
Boja ES, Hoodbhoy T, Fales HM, Dean J. Structural characterization of native mouse zona pellucida proteins using mass spectrometry. J Biol Chem. 2003 Sep 5; 278 (2003 Sep 5; 278; 36):34189-202. [Full Text/Abstract]
Rankin TL, Coleman JS, Epifano O, Hoodbhoy T, Turner SG, Castle PE, Lee E, Gore-Langton R, Dean J. Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs. Dev Cell. 2003 Jul; 5 (2003 Jul; 5; 1):33-43. [Full Text/Abstract]
Zhao M, Gold L, Ginsberg AM, Liang LF, Dean J. Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. Mol Cell Biol. 2002 May; 22 (2002 May; 9; 22):3111-20. [Full Text/Abstract]
Takasaki N, Rankin T, Dean J. Normal gonadal development in mice lacking GPBOX, a homeobox protein expressed in germ cells at the onset of sexual dimorphism. Mol Cell Biol. 2001 Dec; 21 (2001 Dec; 23; 21):8197-202. [Full Text/Abstract]
Rankin TL, O'Brien M, Lee E, Wigglesworth K, Eppig J, Dean J. Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development. 2001 Apr; 128 (128; 2001 Apr; 7):1119-26. [Full Text/Abstract]
Tong ZB, Gold L, Pfeifer KE, Dorward H, Lee E, Bondy CA, Dean J, Nelson LM. Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet. 2000 Nov; 26 (2000 Nov; 3; 26):267-8. [Full Text/Abstract]
Soyal SM, Amleh A, Dean J. FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. Development. 2000 Nov; 127 (127; 2000 Nov; 21):4645-54. [Full Text/Abstract]
Takasaki N, McIsaac R, Dean J. Gpbox (Psx2), a homeobox gene preferentially expressed in female germ cells at the onset of sexual dimorphism in mice. Dev Biol. 2000 Jul 1; 223 (2000 Jul 1; 1; 223):181-93. [Full Text/Abstract]
Rankin T, Talbot P, Lee E, Dean J. Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss. Development. 1999 Sep; 126 (126; 17; 1999 Sep):3847-55. [Full Text/Abstract]
Greenhouse S, Castle PE, Dean J. Antibodies to human ZP3 induce reversible contraception in transgenic mice with 'humanized' zonae pellucidae. Hum Reprod. 1999 Mar; 14 (1999 Mar; 14; 3):593-600. [Full Text/Abstract]
Rankin TL, Tong ZB, Castle PE, Lee E, Gore-Langton R, Nelson LM, Dean J. Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding. Development. 1998 Jul; 125 (13; 1998 Jul; 125):2415-24. [Full Text/Abstract]
Liang L, Soyal SM, Dean J. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec; 124 (124; 1997 Dec; 24):4939-47. [Full Text/Abstract]
Rankin T, Familari M, Lee E, Ginsberg A, Dwyer N, Blanchette-Mackie J, Drago J, Westphal H, Dean J. Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development. 1996 Sep; 122 (122; 1996 Sep; 9):2903-10. [Full Text/Abstract]