U.S. Department of Health and Human Services


A selection of recent and significant publications can be viewed below.

Qiang W, Yau WM, Lu JX, Collinge J, Tycko R. Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes. Nature. 2017 Jan 4; 541 (541; 7636; 2017 Jan 4):217-221. [Full Text/Abstract]
Bayro MJ, Ganser-Pornillos BK, Zadrozny KK, Yeager M, Tycko R. Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles. J Am Chem Soc. 2016 Sep 5; 138 (138; 2016 Sep 5; 37):12029-12032. [Full Text/Abstract]
Bayro MJ, Tycko R. Structure of the Dimerization Interface in the Mature HIV-1 Capsid Protein Lattice from Solid State NMR of Tubular Assemblies. J Am Chem Soc. 2016 Jun 14; 138 (138; 2016 Jun 14; 27):8538-46. [Full Text/Abstract]
Lu JX, Bayro MJ, Tycko R. Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments. J Biol Chem. 2016 Apr 19; 291 (291; 25; 2016 Apr 19):13098-112. [Full Text/Abstract]
Cellmer T, Ferrone FA, Eaton WA. Universality of supersaturation in protein-fiber formation. Nat Struct Mol Biol. 2016 Mar 28; 23 (2016 Mar 28; 23; 5):459-61. [Full Text/Abstract]
Thurber K, Tycko R. Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning. J Magn Reson. 2016 Mar; 264 (264; 2016 Mar):99-106. [Full Text/Abstract]
Chung HS, Piana-Agostinetti S, Shaw DE, Eaton WA. Structural origin of slow diffusion in protein folding. Science. 2015 Sep 25; 349 (6255; 349; 2015 Sep 25):1504-10. [Full Text/Abstract]
Venditti V, Schwieters CD, Grishaev A, Clore GM. Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering. Proc Natl Acad Sci U S A. 2015 Sep 15; 112 (2015 Sep 15; 37; 112):11565-70. [Full Text/Abstract]
Tugarinov V, Libich DS, Meyer V, Roche J, Clore GM. The energetics of a three-state protein folding system probed by high-pressure relaxation dispersion NMR spectroscopy. Angew Chem Int Ed Engl. 2015 Sep 14; 54 (38; 2015 Sep 14; 54):11157-61. [Full Text/Abstract]
Louis JM, Deshmukh L, Sayer JM, Aniana A, Clore GM. Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease. Biochemistry. 2015 Sep 8; 54 (2015 Sep 8; 35; 54):5414-24. [Full Text/Abstract]
Moore E, Tycko R. Micron-scale magnetic resonance imaging of both liquids and solids. J Magn Reson. 2015 Sep 8; 260 (2015 Sep 8; 260):1-9. [Full Text/Abstract]
Nagy-Smith K, Moore E, Schneider J, Tycko R. Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network. Proc Natl Acad Sci U S A. 2015 Aug 11; 112 (32; 2015 Aug 11; 112):9816-21. [Full Text/Abstract]
Libich DS, Tugarinov V, Clore GM. Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR. Proc Natl Acad Sci U S A. 2015 Jun 29; 112 (2015 Jun 29; 29; 112):8817-23. [Full Text/Abstract]
Potapov A, Yau WM, Ghirlando R, Thurber KR, Tycko R. Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization. J Am Chem Soc. 2015 Jun 12; 137 (25; 2015 Jun 12; 137):8294-307. [Full Text/Abstract]
Tycko R. Amyloid polymorphism: structural basis and neurobiological relevance. Neuron. 2015 May 6; 86 (2015 May 6; 86; 3):632-45. [Full Text/Abstract]
Tycko R. On the problem of resonance assignments in solid state NMR of uniformly ¹⁵N,¹³C-labeled proteins. J Magn Reson. 2015 Apr; 253 (2015 Apr; 253):166-72. [Full Text/Abstract]
Baber JL, Louis JM, Clore GM. Dependence of distance distributions derived from double electron-electron resonance pulsed EPR spectroscopy on pulse-sequence time. Angew Chem Int Ed Engl. 2015 Mar 10; 54 (2015 Mar 10; 54; 18):5336-9. [Full Text/Abstract]
Deshmukh L, Ghirlando R, Clore GM. Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy. Proc Natl Acad Sci U S A. 2015 Feb 23; 112 (2015 Feb 23; 112; 11):3374-9. [Full Text/Abstract]
Anthis NJ, Clore GM. Visualizing transient dark states by NMR spectroscopy. Q Rev Biophys. 2015 Feb; 48 (2015 Feb; 48; 1):35-116. [Full Text/Abstract]
Venditti V, Tugarinov V, Schwieters CD, Grishaev A, Clore GM. Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I. Nat Commun. 2015 Jan 12; 6 (6; 2015 Jan 12):5960. [Full Text/Abstract]
Ryu KS, Tugarinov V, Clore GM. Probing the Rate-Limiting Step for Intramolecular Transfer of a Transcription Factor between Specific Sites on the Same DNA Molecule by 15Nz-Exchange NMR Spectroscopy. J Am Chem Soc. 2014 Sep 25; 136 (2014 Sep 25; 41; 136):14369-14372. [Full Text/Abstract]
Guenther M, James R, Marks J, Zhao S, Szabo A, Kidambi S. Adiposity distribution influences circulating adiponectin levels. Transl Res. 2014 Apr 18; 164 (164; 2014 Apr 18; 4):270-7. [Full Text/Abstract]
Fekete T, Pazmandi K, Szabo A, Bacsi A, Koncz G, Rajnavölgyi E. The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin. J Leukoc Biol. 2014 Jul 7; 96 (2014 Jul 7; 4; 96):579-89. [Full Text/Abstract]
Fawzi NL, Libich DS, Ying J, Tugarinov V, Clore GM. Characterizing Methyl-Bearing Side Chain Contacts and Dynamics Mediating Amyloid β Protofibril Interactions Using (13) Cmethyl -DEST and Lifetime Line Broadening. Angew Chem Int Ed Engl. 2014 Aug 11; 53 (39; 53; 2014 Aug 11):10345-10349. [Full Text/Abstract]
Chung HS, Gopich IV. Fast single-molecule FRET spectroscopy: theory and experiment. Phys Chem Chem Phys. 2014 Sep 21; 16 (35; 2014 Sep 21; 16):18644-57. [Full Text/Abstract]
Mantsyzov AB, Maltsev AS, Ying J, Shen Y, Hummer G, Bax A. A maximum entropy approach to the study of residue-specific backbone angle distributions in α-synuclein, an intrinsically disordered protein. Protein Sci. 2014 Sep; 23 (23; 9; 2014 Sep):1275-90. [Full Text/Abstract]
Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M. Enhanced survival from radiation pneumonitis by combined irradiation to the skin. Int J Radiat Biol. 2014 Jun 25; 90 (9; 90; 2014 Jun 25):1-42. [Full Text/Abstract]
Szabo A, Magyarics Z, Pazmandi K, Gopcsa L, Rajnavolgyi E, Bacsi A. TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner. Immunol Cell Biol. 2014 May 20; 92 (92; 8; 2014 May 20):671-8. [Full Text/Abstract]
Tycko R. Physical and structural basis for polymorphism in amyloid fibrils. Protein Sci. 2014 Sep 1; 23 (23; 11; 2014 Sep 1):1528-39. [Full Text/Abstract]
Péczely L, Ollmann T, László K, Kovács A, Gálosi R, Szabó Á, Karádi Z, Lénárd L. Role of D1 Dopamine Receptors of the Ventral Pallidum in Inhibitory Avoidance Learning. Behav Brain Res. 2014 Aug 15; 270 (2014 Aug 15; 270):131-6. [Full Text/Abstract]
Varga R, Janovszky Á, Szabó A, Garab D, Bodnár D, Boros M, Neunzehn J, Wiesmann HP, Piffkó J. A novel method for in vivo visualization of the microcirculation of the mandibular periosteum in rats. Microcirculation. 2014 Aug; 21 (6; 2014 Aug; 21):524-31. [Full Text/Abstract]
Land ME, Cooper RF, Young J, Berg E, Kitchner T, Xiang Q, Szabo A, Ivacic LC, Stepien KE, Page CD, Carroll J, Connor T Jr, Brilliant M. Cone structure in subjects with known genetic relative risk for AMD. Optom Vis Sci. 2014 Aug; 91 (8; 2014 Aug; 91):939-49. [Full Text/Abstract]
Rusai K, Szabo AJ. Recent developments in kidney transplantation in children. Curr Opin Organ Transplant. 2014 Aug; 19 (19; 2014 Aug; 4):381-6. [Full Text/Abstract]
Camer D, Yu Y, Szabo A, Huang XF. The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications. Mol Nutr Food Res. 2014 Aug; 58 (8; 58; 2014 Aug):1750-9. [Full Text/Abstract]
Farkas N, Szabó A, Lóránd V, Sarlós DP, Minier T, Prohászka Z, Czirják L, Varjú C. Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. Rheumatology (Oxford). 2014 Aug; 53 (8; 2014 Aug; 53):1439-45. [Full Text/Abstract]
Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss AL, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica. Cell. 2014 Jul 17; 158 (2014 Jul 17; 2; 158):353-367. [Full Text/Abstract]
Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. [Full Text/Abstract]
Bajory Z, Varga R, Janovszky Á, Pajor L, Szabó A. Microcirculatory effects of selective endothelin-a receptor antagonism in testicular torsion. J Urol. 2014 Jul 8; 192 (6; 2014 Jul 8; 192):1871-1877. [Full Text/Abstract]
de Sancho D, Sirur A, Best RB. Molecular origins of internal friction effects on protein-folding rates. Nat Commun. 2014 Jul 2; 5 (2014 Jul 2; 5):4307. [Full Text/Abstract]
Tycko R. Remote sensing of sample temperatures in nuclear magnetic resonance using photoluminescence of semiconductor quantum dots. J Magn Reson. 2014 Jul; 244C (2014 Jul; 244C):64-67. [Full Text/Abstract]
Yau WM, Thurber KR, Tycko R. Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR. J Magn Reson. 2014 Jul; 244C (2014 Jul; 244C):98-106. [Full Text/Abstract]
Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M. Ras-Related Protein 1 in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure. Arterioscler Thromb Vasc Biol. 2014 Jul; 34 (7; 2014 Jul; 34):1486-94. [Full Text/Abstract]
Schwieters CD, Clore GM. Using small angle solution scattering data in Xplor-NIH structure calculations. Prog Nucl Magn Reson Spectrosc. 2014 Jul; 80C (80C; 2014 Jul):1-11. [Full Text/Abstract]
Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G. Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer. Oncotarget. 2014 Jun 30; 5 (2014 Jun 30; 12; 5):4269-82. [Full Text/Abstract]
Szabó A, Szili K, Szabó JT, Sikovanyecz J, Isaszegi D, Horváth E, Szabó J. Nasal bone length: prenasal thickness ratio: a strong 2D ultrasound marker for Down syndrome. Prenat Diagn. 2014 Jun 25; 34 (12; 34; 2014 Jun 25):1139-1145. [Full Text/Abstract]
Jassim H, Seligman JT, Frelich M, Goldblatt M, Kastenmeier A, Wallace J, Zhao HS, Szabo A, Gould JC. A population-based analysis of emergent versus elective paraesophageal hernia repair using the Nationwide Inpatient Sample. Surg Endosc. 2014 Jun 18; 28 (28; 2014 Jun 18; 12):3473-8. [Full Text/Abstract]
Hocsak E, Cseh A, Szabo A, Bellyei S, Pozsgai E, Kalai T, Hideg K, Sumegi B, Boronkai A. PARP inhibitor attenuated colony formation can be restored by MAP kinase inhibitors in different irradiated cancer cell lines. Int J Radiat Biol. 2014 Jun 17; 90 (12; 2014 Jun 17; 90):1-23. [Full Text/Abstract]
Garab D, Fet N, Szabó A, Tolba RH, Boros M, Hartmann P. Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion. Life Sci. 2014 Jun 6; 105 (105; 1-2; 2014 Jun 6):14-21. [Full Text/Abstract]
Mészáros K, Pruess L, Szabó AJ, Gondan M, Ritz E, Schaefer F. Development of the circadian clockwork in the kidney. Kidney Int. 2014 Jun 4; 86 (86; 2014 Jun 4; 5):915-22. [Full Text/Abstract]
Balogh EP, Mosolygó T, Tiricz H, Szabó AM, Karai A, Kerekes F, Virók DP, Kondorosi E, Burián K. Anti-chlamydial effect of plant peptides. Acta Microbiol Immunol Hung. 61 (2; 61):229-39. [Full Text/Abstract]