Scientists in the lab study diverse topics in chemical physics. These include:
- fundamental aspects of the mechanism of protein folding;
- new techniques and approaches for determining the structure and dynamics of bioactive molecules;
- the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional NMR spectroscopy;
- solid-state NMR methods for structural studies of biopolymers;
- the gap between theory and experiment; and
- the relationships between protein structure, dynamics, and function using ultrafast time-resolved laser spectroscopy and X-ray crystallography.
Experimental techniques include solution and solid-state nuclear magnetic resonance spectroscopy (NMR), time-resolved X-ray crystallography and optical spectroscopy, rapid kinetics methods, and single molecule spectroscopy. The development of fundamental aspects of experimental and theoretical techniques is an active area in the laboratory.