U.S. Department of Health and Human Services

Clinical Research Section

T. Jake Liang, M.D., Chief

Section Staff

Senior Staff


Photo of T. Jake Liang, M.D. 

T. Jake Liang, M.D., Chief, Liver Diseases Branch

M.D. – Harvard Medical School, Boston, MA
Internal Medicine Residency – New York University/Bellevue Hospital Center, New York, NY
Gastroenterology Fellowship – Massachusetts General Hospital, Boston, MA

Photo of Edward Doo, M.D.Edward Doo, M.D., Director, Liver Diseases Research Program

M.D. – Cornell University Medical College, New York, NY
Internal Medicine Residency – The New York Hospital-Cornell Medical Center, New York, NY

 

Photo of Marc Ghany, M.D.

Marc Ghany, M.D., Tenure Track Clinical Investigator, Liver Diseases Branch

M.D. – Royal College of Surgeons in Ireland, Dublin, Ireland
Internal Medicine Residency – Hospital of St. Raphael, New Haven, CT
Gastroenterology Fellowship – Tulane University School of Medicine, New Orleans, LA
Liver Diseases Fellowship – NIDDK, Bethesda, MD
M.H.Sc. – Duke University School of Medicine, Durham, NC

Photo of Theo Heller, M.D.

Theo Heller, M.D., Tenured Clinical Investigator, Liver Diseases Branch

M.D. – University of Witwatersrand Medical school
Internal Medicine Residency – Georgetown University Hospital
Viral Hepatitis Fellowship – NIAID, Bethesda, MD
Gastroenterology Fellowship – University of Maryland School of Medicine
Liver Diseases Fellowship – NIDDK, Bethesda, MD

Photo of Jay Hoofnagle, M.D.

Jay ​Hoofnagle, M.D., Director, Liver Disease Research Branch

M.D. – Yale University School of Medicine, New Haven, CT
Internal Medicine Residency – University of Virginia Health System, Charlottesville, VA
Internal Medicine Residency – VA Medical Center, Washington, DC
Gastroenterology Fellowship – VA Medical Center, Washington, DC

nih_kohchris_Koh.jpgChristopher Koh, M.D. M.H.Sc., Staff Clinician, Liver Diseases Branch

M.D. – Saba University School of Medicine, Netherlands-Antilles
M.H.Sc. - Duke University School of Medicine, Durham, NC
Internal Medicine Residency – Harbor Hospital, Baltimore, MD
Liver Diseases Fellowship – NIDDK, Bethesda, MD
Gastroenterology Fellowship – University of Maryland/NIH Scholars Program, Baltimore, MD & Bethesda, MD

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Yaron Rotman, M.D., Tenure Track Clinical Investigator, Liver Diseases Branch

M.D. – Hebrew University Hadassah Medical School, Jerusalem, Israel
M.Sc. – Hebrew University Hadassah Medical School, Jerusalem, Israel
Internal Medicine Residency – Rabin Medical Center, Petach-Tiqwa, Israel
Gastroenterology Fellowship – Rabin Medical Center, Petach-Tiqwa, Israel
Liver Diseases Fellowship – NIDDK, Bethesda, MD

Photo Not Available

Averell H. Sherker, M.D., Scientific Advisor, Viral Hepatitis and Liver Diseases

M.D. – Queens University Faculty of Health Sciences, Kingston, Canada
Internal Medicine Residency – Mt. Sinai Hosptial University, Toronto, Canada
Gastroenterology Fellowship – University of Toronto, Ontario, Canada
Liver Diseases Fellowship – Stanford University, Stanford, CA

Clinical Hepatology Fellows

Gil Ben-Yakov

Gil Ben-Yakov, M.D., Clinical Fellow

M.D. - Ben-Gurion University, Faculty of Health Sciences, Israel
Internal Medicine Residency - Soroka University Medical Center, Israel
Gastroenterology/Hepatology Fellowship - Soroka University Medical Center, Israel

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver and biliary tract disease, with a highly variable clinical presentation and natural history. The pathogenesis of PSC remains elusive, nevertheless, cumulative evidence suggests its development is immune-mediated and follows an immune priming event in genetically pre-disposed individuals.

The intricate relationships and interactions between host genetics, immune responses, behavioral and environmental triggers underlying the pathogenesis of PSC have not yet been elucidated. My main research interest is to identify those interactions and their role in the development of PSC.

Other research interests of mine include, liver manifestations in syndromes of immune disregulation and understanding the differential metabolic pathways dominating in post prandial state in NAFLD patients versus healthy controls.

Devika Kapuria

Devika Kapuria, M.D., Clinical Fellow

M.D. - Lady Hardinge Medical College, New Dehli, India
Internal Medicine Residency - University of Missouri, Kansas City, MO

Liver disease is fascinating-the liver controls a host of processes in the body ranging from the immune system to metabolism. My interests include delta hepatitis, non-cirrhotic portal hypertension and the association of fatty liver disease with abnormalities in metabolic pathways of the body. The recent advent of novel viral prenylation inhibitors for delta hepatitis is a rapidly developing field; NIDDK has been actively involved in phase 2 studies that show promising results.

Non-cirrhotic portal hypertension is a diverse group of disorders with widely varying causes and outcomes, there has been no treatment identified to modify the natural history of the disease-perhaps given the heterogeneity. My clinical focus is to work on the characterization of the natural history of non-cirrhotic portal hypertension.

I am also interested in the physiologic and metabolic pathways connecting the liver and the cardiovascular system, how changes in one can affect the other.

Ahmed S. Alawad

Ahmed S. Alawad, M.D., Clinical Fellow

M.D. - University of Aleppo, Aleppo, Syria
Internal Medicine Residency - Medstar Franklin Square Medical Center, Baltimore, MD

Fatty liver disease currently affects one third of the United States population and it is projected to become number one cause for liver transplant in 2020. Despite the tremendous advancement in different fields of hepatology, we still have a lot to investigate in the pathogenesis of fatty liver disease and finding treatment for the disease. My primary interest is in evaluating new treatment methods for fatty liver disease, and finding non-invasive methods the could estimate accurately the severity of the disease.

Chunwei Walter Lai, M.D. Ph.D., Clinical Fellow

M.D., Ph.D. - Albert Einstein College of Medicine, Yeshiva University, Bronx, NY
Internal Medicine Residency - Einstein Medical Center Philadelphia, Philadelphia, PA

I was drawn to NIH because of their unique approaches to answer basic biological questions through clinical research trials. One of my research interests is to understand the role of liver immune system in pathogenesis of liver diseases, especially liver cancer and autoimmune liver diseases.  The unique immune tolerogenicity of liver is evident from the low-level immunosuppression required in a HLA-mismatched, orthotopic liver recipient, contrary to other solid organ transplantations. Additionally, the liver confers the same immunotolerance to the kidney in recipients of dual liver-kidney transplant. This phenomenon shows that the liver can modulate systemic immune response but may be predisposed to chronic infection and malignancy. Researchers have explored different methods to modulate the hepatic immune system, and our lab recently showed that gut microbiota-dependent changes in bile acid composition can modulate immune surveillance of liver tumors in a murine model. My goal is to dissect the molecular mechanism using tissue culture and mouse model, and to correlate these findings in human. This research may lead to novel therapies for primary and metastatic liver cancers.

Clinical Specialists


Shelley Anne Ganio, Patient Care Coordinator

 

10 Center Drive, Bldg: 10 CRC, Rm: 4-5722, MSC 16142
T: 301-435-6121
F: 301-435-9160


Elenita M. Rivera, BSN, RN, Research Nurse, Specialist

 

10 Center Drive, Bldg: 10 CRC, Rm: 4-5722, MSC 1614
Bethesda, MD 20892
T: 301-435-6125
F: 301-451-9160


Amy Huang, BSN, BS, BA, RN, Acting Clinical Nurse Manager, Research Nurse, Specialist

 

10 Center Drive, Bldg: 10 CRC, Rm: 4-5722, MSC 1614
Bethesda, MD 20892
T: 301-451-6983
F: 301-435-9160​

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