U.S. Department of Health and Human Services

Immunology Section

Barbara Rehermann, M.D., Chief


A selection of recent and significant publications can be viewed below.

Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell. 2017 Oct 17; 171 (2017 Oct 17; 171; 5):1015-1028.e13. [Full Text/Abstract]
Bolte FJ, O'Keefe AC, Webb LM, Serti E, Rivera E, Liang TJ, Ghany M, Rehermann B. Intra-hepatic Depletion of Mucosal-Associated Invariant T cells in Hepatitis C Virus-induced Liver Inflammation. Gastroenterology. 2017 Aug 2; 153 (153; 5; 2017 Aug 2):1392-1403.e2. [Full Text/Abstract]
Serti E, Chepa-Lotrea X, Kim YJ, Keane M, Fryzek N, Liang TJ, Ghany M, Rehermann B. Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function. Gastroenterology. 2015 Mar 6; 149 (149; 2015 Mar 6; 1):190-200.e2. [Full Text/Abstract]
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection. Hepatology. 2014 Feb 23; 60 (4; 2014 Feb 23; 60):1160-1169. [Full Text/Abstract]
Veerapu NS, Park SH, Tully DC, Allen TM, Rehermann B. Trace amounts of sporadically reappearing HCV RNA can cause infection. J Clin Invest. 2014 Aug 1; 124 (124; 8; 2014 Aug 1):3469-78. [Full Text/Abstract]
Rehermann B, Bertoletti A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology. 2014 Jul 21; 61 (2014 Jul 21; 2; 61):712-21. [Full Text/Abstract]
Serti E, Werner JM, Chattergoon M, Cox AL, Lohmann V, Rehermann B. Monocytes Activate Natural Killer Cells via Inflammasome-induced Interleukin 18 in Response to Hepatitis C Virus Replication. Gastroenterology. 2014 Jul; 147 (147; 2014 Jul; 1):209-220.e3. [Full Text/Abstract]
Kang W, Sung PS, Park SH, Yoon S, Chang DY, Kim S, Han KH, Kim JK, Rehermann B, Chwae YJ, Shin EC. Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8(+) t cell effector functions. Gastroenterology. 2014 May; 146 (146; 2014 May; 5):1351-1360.e4. [Full Text/Abstract]
Park SH, Rehermann B. Immune responses to HCV and other hepatitis viruses. Immunity. 2014 Jan 16; 40 (40; 2014 Jan 16; 1):13-24. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Demino M, Page S, Nagabhyru PR, Rehermann B, Liang TJ, Hoofnagle JH, Heller T. Sequence analysis of hepatitis C virus from patients with relapse after a sustained virological response: relapse or reinfection?. J Infect Dis. 2014 Jan 1; 209 (209; 2014 Jan 1; 1):38-45. [Full Text/Abstract]
Park SH, Veerapu NS, Shin EC, Biancotto A, McCoy JP, Capone S, Folgori A, Rehermann B. Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. Nat Med. 2013 Dec; 19 (19; 2013 Dec; 12):1638-42. [Full Text/Abstract]
Rehermann B. Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells. Nat Med. 2013 Jul; 19 (19; 7; 2013 Jul):859-68. [Full Text/Abstract]
Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet. 2013 Feb; 45 (2; 2013 Feb; 45):164-71. [Full Text/Abstract]
Park H, Serti E, Eke O, Muchmore B, Prokunina-Olsson L, Capone S, Folgori A, Rehermann B. IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection. Hepatology. 2012 Dec; 56 (2012 Dec; 56; 6):2060-70. [Full Text/Abstract]
Park SH, Shin EC, Capone S, Caggiari L, De Re V, Nicosia A, Folgori A, Rehermann B. Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus. Gastroenterology. 2012 Oct; 143 (2012 Oct; 4; 143):1048-60.e4. [Full Text/Abstract]
Raghuraman S, Park H, Osburn WO, Winkelstein E, Edlin BR, Rehermann B. Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion. J Infect Dis. 2012 Mar 1; 205 (205; 2012 Mar 1; 5):763-71. [Full Text/Abstract]
Edlich B, Ahlenstiel G, Zabaleta Azpiroz A, Stoltzfus J, Noureddin M, Serti E, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients. Hepatology. 2012 Jan; 55 (55; 1; 2012 Jan):39-48. [Full Text/Abstract]
Ahlenstiel G, Edlich B, Hogdal LJ, Rotman Y, Noureddin M, Feld JJ, Holz LE, Titerence RH, Liang TJ, Rehermann B. Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C. Gastroenterology. 2011 Oct; 141 (4; 141; 2011 Oct):1231-9, 1239.e1-2. [Full Text/Abstract]
Shin EC, Park SH, Demino M, Nascimbeni M, Mihalik K, Major M, Veerapu NS, Heller T, Feinstone SM, Rice CM, Rehermann B. Delayed induction, not impaired recruitment, of specific CD8⁺ T cells causes the late onset of acute hepatitis C. Gastroenterology. 2011 Aug; 141 (2; 141; 2011 Aug):686-95, 695.e1. [Full Text/Abstract]
Veerapu NS, Raghuraman S, Liang TJ, Heller T, Rehermann B. Sporadic reappearance of minute amounts of hepatitis C virus RNA after successful therapy stimulates cellular immune responses. Gastroenterology. 2011 Feb; 140 (2; 2011 Feb; 140):676-685.e1. [Full Text/Abstract]
Ahlenstiel G, Titerence RH, Koh C, Edlich B, Feld JJ, Rotman Y, Ghany MG, Hoofnagle JH, Liang TJ, Heller T, Rehermann B. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology. 2010 Jan; 138 (138; 2010 Jan; 1):325-35.e1-2. [Full Text/Abstract]
Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009 Jul; 119 (7; 119; 2009 Jul):1745-54. [Full Text/Abstract]
Mix H, Weiler-Normann C, Thimme R, Ahlenstiel G, Shin EC, Herkel J, David CS, Lohse AW, Rehermann B. Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis. Gastroenterology. 2008 Dec; 135 (2008 Dec; 6; 135):2107-18. [Full Text/Abstract]
Mizukoshi E, Eisenbach C, Edlin BR, Newton KP, Raghuraman S, Weiler-Normann C, Tobler LH, Busch MP, Carrington M, McKeating JA, O'Brien TR, Rehermann B. Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. J Infect Dis. 2008 Jul 15; 198 (2008 Jul 15; 2; 198):203-12. [Full Text/Abstract]
Ahlenstiel G, Martin MP, Gao X, Carrington M, Rehermann B. Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses. J Clin Invest. 2008 Mar; 118 (118; 2008 Mar; 3):1017-26. [Full Text/Abstract]
Rehermann B. Chronic infections with hepatotropic viruses: mechanisms of impairment of cellular immune responses. Semin Liver Dis. 2007 May; 27 (2007 May; 2; 27):152-60. [Full Text/Abstract]
Rehermann B, Naoumov NV. Immunological techniques in viral hepatitis. J Hepatol. 2007 Mar; 46 (46; 3; 2007 Mar):508-20. [Full Text/Abstract]
Shin EC, Seifert U, Kato T, Rice CM, Feinstone SM, Kloetzel PM, Rehermann B. Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J Clin Invest. 2006 Nov; 116 (116; 11; 2006 Nov):3006-14. [Full Text/Abstract]
Shin EC, Rehermann B. Taking the brake off T cells in chronic viral infection. Nat Med. 2006 Mar; 12 (2006 Mar; 12; 3):276-7. [Full Text/Abstract]
Rehermann B, Shin EC. Private aspects of heterologous immunity. J Exp Med. 2005 Mar 7; 201 (201; 2005 Mar 7; 5):667-70. [Full Text/Abstract]
Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005 Mar; 5 (2005 Mar; 3; 5):215-29. [Full Text/Abstract]
Seifert U, Liermann H, Racanelli V, Halenius A, Wiese M, Wedemeyer H, Ruppert T, Rispeter K, Henklein P, Sijts A, Hengel H, Kloetzel PM, Rehermann B. Hepatitis C virus mutation affects proteasomal epitope processing. J Clin Invest. 2004 Jul; 114 (2004 Jul; 2; 114):250-9. [Full Text/Abstract]
Rahman F, Heller T, Sobao Y, Mizukoshi E, Nascimbeni M, Alter H, Herrine S, Hoofnagle J, Liang TJ, Rehermann B. Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology. 2004 Jul; 40 (40; 2004 Jul; 1):87-97. [Full Text/Abstract]
Racanelli V, Behrens SE, Aliberti J, Rehermann B. Dendritic cells transfected with cytopathic self-replicating RNA induce crosspriming of CD8+ T cells and antiviral immunity. Immunity. 2004 Jan; 20 (20; 2004 Jan; 1):47-58. [Full Text/Abstract]
Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH, Liang TJ, Alter H, Rehermann B. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol. 2002 Sep 15; 169 (2002 Sep 15; 6; 169):3447-58. [Full Text/Abstract]
Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, Manns MP, Rehermann B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med. 2000 May; 6 (6; 2000 May; 5):578-82. [Full Text/Abstract]
Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med. 1996 Oct; 2 (1996 Oct; 2; 10):1104-8. [Full Text/Abstract]