U.S. Department of Health and Human Services

Clinical Research Section - Liver and Energy Metabolism Unit

Yaron Rotman, M.D., M.Sc., Chief


A selection of recent and significant publications can be viewed below.

Rotman Y, Neuschwander-Tetri BA. Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit. Hepatology. 2017 Feb 2; 65 (4; 2017 Feb 2; 65):1088-1090. [Full Text/Abstract]
Rotman Y, Sanyal AJ. Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. Gut. 2016 Sep 19; 66 (66; 2016 Sep 19; 1):180-190. [Full Text/Abstract]
Noureddin M, Rotman Y, Zhang F, Park H, Rehermann B, Thomas E, Liang TJ. Hepatic expression levels of interferons and interferon-stimulated genes in patients with chronic hepatitis C: A phenotype-genotype correlation study. Genes Immun. 2015 May 28; 16 (2015 May 28; 16; 5):321-9. [Full Text/Abstract]
Shimony MK, Schliep KC, Schisterman EF, Ahrens KA, Sjaarda LA, Rotman Y, Perkins NJ, Pollack AZ, Wactawski-Wende J, Mumford SL. The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study. Eur J Nutr. 2015 Mar 24; 55 (2015 Mar 24; 2; 55):569-576. [Full Text/Abstract]
Pollack AZ, Mumford SL, Mendola P, Perkins NJ, Rotman Y, Wactawski-Wende J, Schisterman EF. Kidney biomarkers associated with blood lead, mercury, and cadmium in premenopausal women: a prospective cohort study. J Toxicol Environ Health A. 2015; 78 (2015; 2; 78):119-31. [Full Text/Abstract]
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection. Hepatology. 2014 Feb 23; 60 (4; 2014 Feb 23; 60):1160-1169. [Full Text/Abstract]
Njei B, Rotman Y, Ditah I, Lim JK. Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology. 2014 Aug 20; 61 (2014 Aug 20; 1; 61):191-199. [Full Text/Abstract]
Guedj J, Rotman Y, Cotler SJ, Koh C, Schmid P, Albrecht J, Haynes-Williams V, Liang TJ, Hoofnagle JH, Heller T, Dahari H. Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling. Hepatology. 2014 Aug 7; 60 (6; 2014 Aug 7; 60):1902-10. [Full Text/Abstract]
Heller T, Rotman Y, Koh C, Clark S, Haynes-Williams V, Chang R, McBurney R, Schmid P, Albrecht J, Kleiner DE, Ghany MG, Liang TJ, Hoofnagle JH. Long-term therapy of chronic delta hepatitis with peginterferon alfa. Aliment Pharmacol Ther. 2014 Jul; 40 (40; 2014 Jul; 1):93-104. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014 Jan; 63 (2014 Jan; 63; 1):161-9. [Full Text/Abstract]
Han H, Noureddin M, Witthaus M, Park YJ, Hoofnagle JH, Jake Liang T, Rotman Y. Temperature Rise After Peginterferon Alfa-2a Injection in Patients with Chronic Hepatitis C is Associated with Virological Response and is Modulated by IL28B Genotype. J Hepatol. 2013 Nov; 59 (59; 2013 Nov; 5):957-63. [Full Text/Abstract]
Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ. HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons. Gastroenterology. 2012 Apr; 142 (4; 2012 Apr; 142):978-88. [Full Text/Abstract]
Edlich B, Ahlenstiel G, Zabaleta Azpiroz A, Stoltzfus J, Noureddin M, Serti E, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients. Hepatology. 2012 Jan; 55 (55; 1; 2012 Jan):39-48. [Full Text/Abstract]
Ahlenstiel G, Edlich B, Hogdal LJ, Rotman Y, Noureddin M, Feld JJ, Holz LE, Titerence RH, Liang TJ, Rehermann B. Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C. Gastroenterology. 2011 Oct; 141 (4; 141; 2011 Oct):1231-9, 1239.e1-2. [Full Text/Abstract]
Feld JJ, Modi AA, El-Diwany R, Rotman Y, Thomas E, Ahlenstiel G, Titerence R, Koh C, Cherepanov V, Heller T, Ghany MG, Park Y, Hoofnagle JH, Liang TJ. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders. Gastroenterology. 2011 Mar; 140 (2011 Mar; 140; 3):830-9. [Full Text/Abstract]
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, NASH CRN. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology. 2010 Sep; 52 (2010 Sep; 3; 52):894-903. [Full Text/Abstract]
Feld JJ, Lutchman GA, Heller T, Hara K, Pfeiffer JK, Leff RD, Meek C, Rivera M, Ko M, Koh C, Rotman Y, Ghany MG, Haynes-Williams V, Neumann AU, Liang TJ, Hoofnagle JH. Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology. 2010 Jul; 139 (2010 Jul; 139; 1):154-62.e4. [Full Text/Abstract]
Rotman Y, Borg BB, Soza A, Feld JJ, Modi AA, Loomba R, Lutchman G, Rivera E, Doo E, Ghany MG, Heller T, Neumann AU, Liang TJ, Hoofnagle JH. Low- and standard-dose peginterferon alfa-2a for chronic hepatitis C, genotype 2 or 3: efficacy, tolerability, viral kinetics and cytokine response. Aliment Pharmacol Ther. 2010 May; 31 (2010 May; 9; 31):1018-27. [Full Text/Abstract]
Ahlenstiel G, Titerence RH, Koh C, Edlich B, Feld JJ, Rotman Y, Ghany MG, Hoofnagle JH, Liang TJ, Heller T, Rehermann B. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology. 2010 Jan; 138 (138; 2010 Jan; 1):325-35.e1-2. [Full Text/Abstract]
Rotman Y, Liang TJ. Coinfection with hepatitis C virus and human immunodeficiency virus: virological, immunological, and clinical outcomes. J Virol. 2009 Aug; 83 (83; 2009 Aug; 15):7366-74. [Full Text/Abstract]
Rotman Y, Brown TA, Hoofnagle JH. Evaluation of the patient with hepatitis B. Hepatology. 2009 May; 49 (49; 5 Suppl; 2009 May):S22-7. [Full Text/Abstract]
Rotman Y, Katz L, Cohen M, Cohen-Ezra O, Manhaim V, Braun M, Ben-Ari Z, Tur-Kaspa R. Low weight predicts neutropenia and peginterferon alfa-2a dose reductions during treatment for chronic hepatitis C. J Viral Hepat. 2009 May; 16 (16; 5; 2009 May):340-5. [Full Text/Abstract]
von Rosenvinge EC, Koh C, Rotman Y, Lim RM. Electronic clinical challenges and images in GI. Gastrointestinal malignant melanoma. Gastroenterology. 2008 Jul; 135 (2008 Jul; 135; 1):e5-6. [Full Text/Abstract]
Schmilovitz-Weiss H, Niv Y, Pappo O, Halpern M, Sulkes J, Braun M, Barak N, Rotman Y, Cohen M, Waked A, Tur-Kaspa R, Ben-Ari Z. The 13C-caffeine breath test detects significant fibrosis in patients with nonalcoholic steatohepatitis. J Clin Gastroenterol. 2008 Apr; 42 (2008 Apr; 42; 4):408-12. [Full Text/Abstract]
Cohen M, Bachmatov L, Ben-Ari Z, Rotman Y, Tur-Kaspa R, Zemel R. Development of specific antibodies to an ARF protein in treated patients with chronic HCV infection. Dig Dis Sci. 2007 Sep; 52 (9; 2007 Sep; 52):2427-32. [Full Text/Abstract]
Bar-Yosef O, Rotman Y, Nelken I. Responses of neurons in cat primary auditory cortex to bird chirps: effects of temporal and spectral context. J Neurosci. 2002 Oct 1; 22 (19; 2002 Oct 1; 22):8619-32. [Full Text/Abstract]
Rotman Y, Tur-Kaspa R. Transmission of hepatitis B and C viruses--update. Isr Med Assoc J. 2001 May; 3 (2001 May; 3; 5):357-9. [Full Text/Abstract]
Rotman Y, Bar-Yosef O, Nelken I. Relating cluster and population responses to natural sounds and tonal stimuli in cat primary auditory cortex. Hear Res. 2001 Feb; 152 (1-2; 2001 Feb; 152):110-27. [Full Text/Abstract]
Nelken I, Rotman Y, Bar Yosef O. Responses of auditory-cortex neurons to structural features of natural sounds. Nature. 1999 Jan 14; 397 (397; 1999 Jan 14; 6715):154-7. [Full Text/Abstract]