U.S. Department of Health and Human Services

Clinical Research Section - Liver and Energy Metabolism Unit

Yaron Rotman, M.D., M.Sc., Chief


A selection of recent and significant publications can be viewed below.

Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection. Hepatology. 2014 Feb 23; 60 (4; 2014 Feb 23; 60):1160-1169. [Full Text/Abstract]
Heller T, Rotman Y, Koh C, Clark S, Haynes-Williams V, Chang R, McBurney R, Schmid P, Albrecht J, Kleiner DE, Ghany MG, Liang TJ, Hoofnagle JH. Long-term therapy of chronic delta hepatitis with peginterferon alfa. Aliment Pharmacol Ther. 2014 Jul; 40 (40; 2014 Jul; 1):93-104. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014 Jan; 63 (2014 Jan; 63; 1):161-9. [Full Text/Abstract]
Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ. HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons. Gastroenterology. 2012 Apr; 142 (4; 2012 Apr; 142):978-88. [Full Text/Abstract]
Edlich B, Ahlenstiel G, Zabaleta Azpiroz A, Stoltzfus J, Noureddin M, Serti E, Feld JJ, Liang TJ, Rotman Y, Rehermann B. Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients. Hepatology. 2012 Jan; 55 (55; 1; 2012 Jan):39-48. [Full Text/Abstract]
Ahlenstiel G, Edlich B, Hogdal LJ, Rotman Y, Noureddin M, Feld JJ, Holz LE, Titerence RH, Liang TJ, Rehermann B. Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C. Gastroenterology. 2011 Oct; 141 (4; 141; 2011 Oct):1231-9, 1239.e1-2. [Full Text/Abstract]
Feld JJ, Modi AA, El-Diwany R, Rotman Y, Thomas E, Ahlenstiel G, Titerence R, Koh C, Cherepanov V, Heller T, Ghany MG, Park Y, Hoofnagle JH, Liang TJ. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders. Gastroenterology. 2011 Mar; 140 (2011 Mar; 140; 3):830-9. [Full Text/Abstract]
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, NASH CRN. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology. 2010 Sep; 52 (2010 Sep; 3; 52):894-903. [Full Text/Abstract]
Feld JJ, Lutchman GA, Heller T, Hara K, Pfeiffer JK, Leff RD, Meek C, Rivera M, Ko M, Koh C, Rotman Y, Ghany MG, Haynes-Williams V, Neumann AU, Liang TJ, Hoofnagle JH. Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology. 2010 Jul; 139 (2010 Jul; 139; 1):154-62.e4. [Full Text/Abstract]
Ahlenstiel G, Titerence RH, Koh C, Edlich B, Feld JJ, Rotman Y, Ghany MG, Hoofnagle JH, Liang TJ, Heller T, Rehermann B. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology. 2010 Jan; 138 (138; 2010 Jan; 1):325-35.e1-2. [Full Text/Abstract]
Rotman Y, Liang TJ. Coinfection with hepatitis C virus and human immunodeficiency virus: virological, immunological, and clinical outcomes. J Virol. 2009 Aug; 83 (83; 2009 Aug; 15):7366-74. [Full Text/Abstract]
Rotman Y, Brown TA, Hoofnagle JH. Evaluation of the patient with hepatitis B. Hepatology. 2009 May; 49 (49; 5 Suppl; 2009 May):S22-7. [Full Text/Abstract]
von Rosenvinge EC, Koh C, Rotman Y, Lim RM. Electronic clinical challenges and images in GI. Gastrointestinal malignant melanoma. Gastroenterology. 2008 Jul; 135 (2008 Jul; 135; 1):e5-6. [Full Text/Abstract]
Schmilovitz-Weiss H, Niv Y, Pappo O, Halpern M, Sulkes J, Braun M, Barak N, Rotman Y, Cohen M, Waked A, Tur-Kaspa R, Ben-Ari Z. The 13C-caffeine breath test detects significant fibrosis in patients with nonalcoholic steatohepatitis. J Clin Gastroenterol. 2008 Apr; 42 (2008 Apr; 42; 4):408-12. [Full Text/Abstract]
Cohen M, Bachmatov L, Ben-Ari Z, Rotman Y, Tur-Kaspa R, Zemel R. Development of specific antibodies to an ARF protein in treated patients with chronic HCV infection. Dig Dis Sci. 2007 Sep; 52 (9; 2007 Sep; 52):2427-32. [Full Text/Abstract]
Bar-Yosef O, Rotman Y, Nelken I. Responses of neurons in cat primary auditory cortex to bird chirps: effects of temporal and spectral context. J Neurosci. 2002 Oct 1; 22 (19; 2002 Oct 1; 22):8619-32. [Full Text/Abstract]