|Mutant Mouse: Kmt2d (lysine (K)-specific methyltransferase 2D) (MII4 LoxP Mouse)|
Mll4-flox. Conditional knockout mice for the histone methyltransferase Mll4 (Kmt2d) will help understand its role as a tumor suppressor.
Mono- and di-methylations on histone H3 lysine 4 (H3K4me1 and H3K4me2) are epigenetic marks for transcriptional…
|Mutant Mouse: Kdm6a (lysine (K)-specific demethylase 6A) (UTX Knockin Mouse)|
UTX-KI. Enzyme-dead knockin (KI) mice for the histone demethylase UTX (Kdm6a) will help understand its role in tumor suppression and stem cell–mediated tissue regeneration.
Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are…
|Pituitary TRH receptor (U.S. Patent Number 5,288,621)|
Disclosed for the first time is the isolation, sequence, and expression cloning of a cDNA encoding for pituitary thyrotropin-releasing hormone receptor, as well as the amino acid sequence for the receptor per se.
|Receptors that regulate cell signaling relating to chemokines (U.S. Patent Number 6,365,356)|
A method for discovering molecules that regulate cell signaling specific to the dual presence of Duffy antigen receptor for chemokines (DARC) and a chemokine receptor selected from the group consisting of a CXC receptor, a CC receptor and a CXXXC…
|Methods of identifying negative antagonists for G protein coupled receptors (U.S. Patent Number 6,087,115)|
The present invention is directed to a constitutively active G protein coupled receptor of human herpesvirus 8, as well as a method of identifying negative antagonists of a constitutively active G protein coupled receptor. The method comprises…
|Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor (U.S. Patent Number 6,403,305)|
The present invention is directed to a strategy to discover small peptides that will activate any G protein coupled receptor (GPCR) or inactivate any constitutively active GPCR. The strategy uses combinatorial peptide libraries to screen millions of…
|Adenovirus gene expression system (U.S. Patent Number 6,824,770)|
The invention is directed to an adenoviral vector comprising (a) at least one insertion site for cloning a heterologous gene, and, in an orientation opposite to the direction of transcription of the adenoviral region into which it is inserted, (b) a…
|Low molecular weight thyroid stimulating hormone receptor (tshr) agonists (U.S. Patent Application Number WO 2010047674 A1)|
NIH investigators have discovered a series of low molecular weight thyroid-stimulating hormone (TSH) receptor modulators for use in the procedure to detect residual thyroid cancer cells following thyroidectomy. As small molecules, these compounds are…
|Inverse agonists and neutral antagonists for the tsh receptor (U.S. Patent Application Number WO 2011127388 A2)|
TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.
|UTX LoxP Mouse
(Mutant Mouse: Kdm6a (lysine (K)-specific demethylase 6A))
UTX-flox. Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor.
Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for…