U.S. Department of Health and Human Services

Molecular and Clinical Hematology Branch

Griffin P. Rodgers, M.D., M.A.C.P, Chief

​Research Images

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Cover of Nature Review Drug Discovery, May 2018

Source: Rodgers G, Austin C, Anderson J, Pawlyk A, Colvis C, Margolis R, Baker J. Glimmers in illuminating the druggable genome. Nat Rev Drug Disc. 17(5): 301-302, 2018.

Cover of Nature Reviews Drug DiscoveryEnlarge
Blood drawn from a sickle cell patient (top). Blood drawn from a sickle cell patient after stem cell transplant (bottom).

Source: NIH Molecular and Clinical Hematology Branch

Blood drawn from a sickle cell patient (top). Blood drawn from a sickle cell patient after stem cell transplant (bottom).Enlarge
Model of HU Activation of γ-globin Expression

Source: Zhu J, Chin K, Aerbajinai W, Kumkhaek C, Li H, Rodgers GP. Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression. Blood. 2014 Aug 14; 124 (124; 2014 Aug 14; 7):1146-56.

Model of HU Activation of γ-globin ExpressionEnlarge
OLFM4 is a negative regulator of mouse innate immunity against S. aureus infection

Source: Liu WL, Yan M, Sugui JA, Li HZ, Kwon-Chung KJ,  Coleman WG, Rodgers GP. Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease. J. Clin. Invest. 123: 3751-3755, 2013.

OLFM4 is a negative regulator of mouse innate immunity against S. aureus infectionEnlarge
Cover of Blood, April 2013

Source: Kumkhaek C, Aerbajinai W, Liu W, Zhu J, Uchida N, Kurlander R, Hsieh MM, Tisdale JF, Rodgers GP. MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway. Blood. 2013 Apr 18; 121 (121; 16; 2013 Apr 18):3216-27.

Blood Magazine Cover – April 18, 2013Enlarge