U.S. Department of Health and Human Services

Diabetes, Endocrinology, and Obesity Branch

Marc L. Reitman, M.D., Ph.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Funderburk SC, Krashes MJ. Neuroendocrinology: Electromagnetic control of neural activity - prospective physics for physicians. Nat Rev Endocrinol. 2016 May 12; 12 (2016 May 12; 6; 12):316-7. [Full Text/Abstract]
Li C, Krashes MJ. Foraging and flight trump defense and fight. Nat Neurosci. 2016 Apr 26; 19 (2016 Apr 26; 19; 5):645-6. [Full Text/Abstract]
Decalf J, Tarbell KV, Casrouge A, Price JD, Linder G, Mottez E, Sultanik P, Mallet V, Pol S, Duffy D, Albert ML. Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies. EMBO Mol Med. 2016 Apr 9; 8 (6; 8; 2016 Apr 9):679-83. [Full Text/Abstract]
Xiao C, Reitman ML. Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab. 2016 Apr 4; (2016 Apr 4). [Full Text/Abstract]
Burnett CJ, Krashes MJ. Acute Glucose Response Properties Beyond Feeding. Trends Mol Med. 2016 Apr 1; 22 (2016 Apr 1; 5; 22):356-8. [Full Text/Abstract]
Kassai A, Muniyappa R, Levenson AE, Walter MF, Abel BS, Ring M, Taylor SI, Biddinger SB, Skarulis MC, Gorden P, Brown RJ. Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy. J Clin Endocrinol Metab. 2016 Feb 22; 101 (2016 Feb 22; 101; 4):1790-7. [Full Text/Abstract]
Levenson AE, Haas ME, Miao J, Brown RJ, de Ferranti SD, Muniyappa R, Biddinger SB. Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients. Endocrinology. 2016 Jan 29; 157 (157; 2016 Jan 29; 4):1421-1429. [Full Text/Abstract]
Rahman MJ, Rahir G, Dong MB, Zhao Y, Rodrigues KB, Hotta-Iwamura C, Chen Y, Guerrero A, Tarbell KV. Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1. J Immunol. 2016 Jan 29; 196 (196; 2016 Jan 29; 5):2031-40. [Full Text/Abstract]
Krashes MJ, Lowell BB, Garfield AS. Melanocortin-4 receptor-regulated energy homeostasis. Nat Neurosci. 2016 Jan 27; 19 (2016 Jan 27; 19; 2):206-19. [Full Text/Abstract]
Lateef DM, Xiao C, Brychta RJ, Diedrich A, Schnermann J, Reitman ML. Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism. Am J Physiol Heart Circ Physiol. 2016 Jan 22; 310 (7; 2016 Jan 22; 310):H891-8. [Full Text/Abstract]
Cochran E, Brown RJ, Gorden P. COMMENTARY. Endocr Pract. 2016 Jan 20; (2016 Jan 20). [Full Text/Abstract]
Hotta-Iwamura C, Tarbell KV. Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment. J Leukoc Biol. 2016 Jan 20; 100 (100; 2016 Jan 20; 1):65-80. [Full Text/Abstract]
Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nat Commun. 2016 Jan 8; 7 (2016 Jan 8; 7):10268. [Full Text/Abstract]
Carlin JL, Tosh DK, Xiao C, Piñol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML. Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors. J Pharmacol Exp Ther. 2015 Nov 25; 356 (2015 Nov 25; 2; 356):475-83. [Full Text/Abstract]
Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P. Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. Expert Rev Clin Pharmacol. 2015 Oct 14; 9 (9; 2015 Oct 14; 1):1-10. [Full Text/Abstract]
Brychta RJ, Arnardottir NY, Johannsson E, Wright EC, Eiriksdottir G, Gudnason V, Marinac CR, Davis M, Koster A, Caserotti P, Sveinsson T, Harris T, Chen KY. Influence of Day Length and Physical Activity on Sleep Patterns in Older Icelandic Men and Women. J Clin Sleep Med. 2015 Sep 14; 12 (2015 Sep 14; 2; 12):203-213. [Full Text/Abstract]
Arnardottir NY, Koster A, Domelen DR, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Sigurdsson S, Johannsson E, Chen KY, Gudnason V, Harris TB, Launer LJ, Sveinsson T. Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Behav Brain Res. 2015 Sep 10; 296 (296; 2015 Sep 10):118-24. [Full Text/Abstract]
Dong MB, Rahman MJ, Tarbell KV. Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation. J Immunol Methods. 2015 Sep 4; 432 (432; 2015 Sep 4):4-12. [Full Text/Abstract]
Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV 3rd, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metab. 2015 Sep 1; 22 (3; 22; 2015 Sep 1):427-36. [Full Text/Abstract]
Belcher BR, Berrigan D, Papachristopoulou A, Brady SM, Bernstein SB, Brychta RJ, Hattenbach JD, Tigner IL Jr, Courville AB, Drinkard BE, Smith KP, Rosing DR, Wolters PL, Chen KY, Yanovski JA. Effects of Interrupting Children's Sedentary Behaviors With Activity on Metabolic Function: A Randomized Trial. J Clin Endocrinol Metab. 2015 Aug 27; 100 (100; 10; 2015 Aug 27):3735-3743. [Full Text/Abstract]
Abel BS, Muniyappa R, Stratton P, Skarulis MC, Gorden P, Brown RJ. Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients. Neuroendocrinology. 2015 Aug 25; 103 (3-4; 2015 Aug 25; 103):402-7. [Full Text/Abstract]
Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015 Aug 12; 22 (2015 Aug 12; 4; 22):646-57. [Full Text/Abstract]
Zhao Y, Tarbell KV. Comment on Sofi et al. pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence. Diabetes 2014;63:632-644. Diabetes. 2015 Aug; 64 (8; 64; 2015 Aug):e19. [Full Text/Abstract]
Brown RJ, Meehan CA, Gorden P. Leptin Does Not Mediate Hypertension Associated With Human Obesity. Cell. 2015 Jul 30; 162 (2015 Jul 30; 162; 3):465-6. [Full Text/Abstract]
Tarbell KV, Rane SG. Saving β cell function in the NIK of time. J Exp Med. 2015 Jul 27; 212 (2015 Jul 27; 212; 8):1140-1. [Full Text/Abstract]
Meehan CA, Cochran E, Mattingly M, Gorden P, Brown RJ. Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance. Medicine (Baltimore). 2015 Jul; 94 (94; 2015 Jul; 30):e1160. [Full Text/Abstract]
Webber ES, Bonci A, Krashes MJ. The elegance of energy balance: Insight from circuit-level manipulations. Synapse. 2015 Jun 30; 69 (69; 2015 Jun 30; 9):461-74. [Full Text/Abstract]
Price JD, Hotta-Iwamura C, Zhao Y, Beauchamp NM, Tarbell KV. DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes. Diabetes. 2015 Jun 12; 64 (64; 2015 Jun 12; 10):3521-31. [Full Text/Abstract]
Xiao C, Goldgof M, Gavrilova O, Reitman ML. Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C. Obesity (Silver Spring). 2015 Jun 5; 23 (2015 Jun 5; 23; 7):1450-1459. [Full Text/Abstract]
Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML. Integration of body temperature into the analysis of energy expenditure in the mouse. Mol Metab. 2015 Jun; 4 (6; 4; 2015 Jun):461-70. [Full Text/Abstract]
Tiano JP, Springer DA, Rane SG. SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. J Biol Chem. 2015 May 1; 290 (2015 May 1; 18; 290):11431. [Full Text/Abstract]
Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 Apr 29; 86 (86; 4; 2015 Apr 29):936-46. [Full Text/Abstract]
Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Apr 27; 18 (6; 2015 Apr 27; 18):863-71. [Full Text/Abstract]
Brown RJ, Chan JL, Jaffe ES, Cochran E, DePaoli AM, Gautier JF, Goujard C, Vigouroux C, Gorden P. Lymphoma in acquired generalized lipodystrophy. Leuk Lymphoma. 2015 Apr 12; 57 (2015 Apr 12; 1; 57):1-21. [Full Text/Abstract]
Sasai H, Brychta RJ, Wood RP, Rothney MP, Zhao X, Skarulis MC, Chen KY. Does Visceral Fat Estimated by Dual-Energy X-ray Absorptiometry Independently Predict Cardiometabolic Risks in Adults?. J Diabetes Sci Technol. 2015 Mar 23; 9 (2015 Mar 23; 4; 9):917-24. [Full Text/Abstract]
Diker-Cohen T, Cochran E, Gorden P, Brown RJ. Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin. J Clin Endocrinol Metab. 2015 Mar 3; 100 (2015 Mar 3; 100; 5):1802-1810. [Full Text/Abstract]
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC. RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals. J Clin Endocrinol Metab. 2015 Feb 12; 100 (100; 2015 Feb 12; 4):1639-1645. [Full Text/Abstract]
Cypess AM, Weiner LS, Roberts-Toler C, Franquet Elía E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015 Jan 6; 21 (2015 Jan 6; 21; 1):33-8. [Full Text/Abstract]
Price JD, Tarbell KV. The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases. Front Immunol. 2015; 6 (2015; 6):288. [Full Text/Abstract]
Fernandez P, Scaffidi P, Markert E, Lee JH, Rane S, Misteli T. Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. Cell Rep. 2014 Oct 1; 9 (2014 Oct 1; 9; 1):248-60. [Full Text/Abstract]
Cypess AM, Haft CR, Laughlin MR, Hu HH. Brown fat in humans: consensus points and experimental guidelines. Cell Metab. 2014 Sep 2; 20 (20; 2014 Sep 2; 3):408-15. [Full Text/Abstract]
Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ. Lipid Regulation in Lipodystrophy Versus the Obesity-Associated Metabolic Syndrome: The Dissociation of HDL-C and Triglycerides. J Clin Endocrinol Metab. 2014 Jun 13; 99 (99; 2014 Jun 13; 9):E1676-E1680. [Full Text/Abstract]
Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes Cancer. 2014 Sep; 5 (9-10; 5; 2014 Sep):306-19. [Full Text/Abstract]
Srinivasa S, Wong K, Fitch KV, Wei J, Petrow E, Cypess AM, Torriani M, Grinspoon SK. Effects of lifestyle modification and metformin on irisin and FGF21 among HIV-infected subjects with the metabolic syndrome. Clin Endocrinol (Oxf). 2014 Aug 16; 82 (2014 Aug 16; 82; 5):678-85. [Full Text/Abstract]
Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5; 20 (20; 2014 Aug 5; 2):333-45. [Full Text/Abstract]
Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest. 2014 Aug 1; 124 (124; 8; 2014 Aug 1):3339-51. [Full Text/Abstract]
O'Connor MY, Thoreson CK, Ricks M, Courville AB, Thomas F, Yao J, Katzmarzyk PT, Sumner AE. Worse cardiometabolic health in African immigrant men than African American men: reconsideration of the healthy immigrant effect. Metab Syndr Relat Disord. 2014 Aug; 12 (6; 2014 Aug; 12):347-53. [Full Text/Abstract]
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30; 6 (6; 247; 2014 Jul 30):247ra103. [Full Text/Abstract]
Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality. J Biol Chem. 2014 Jul 11; 289 (28; 2014 Jul 11; 289):19341-50. [Full Text/Abstract]
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 2014 Jul 3; 158 (158; 1; 2014 Jul 3):69-83. [Full Text/Abstract]