About the Section
The section on translational endocrinology conducts clinical trials to better understand disorders of cortisol excess and deficiency, such as Cushing's syndrome, glucocorticoid resistance and adrenal insufficiency. Cushing's syndrome is viewed as a model of obesity, and investigates the mechanisms by which cortisol may induce weight gain. Adrenal insufficiency is studied from the perspective of permanent disease (such as autoimmune adrenalitis) as well as reversible disorders of secondary adrenal insufficiency, such as occur after recovery from Cushing's syndrome. These models may suggest new ways to treat obesity as well as the problem of exogenous pharmacologic use of glucocorticoids. The section collaborates with others in NCI (glucocorticoid receptors; endocrine and thoracic surgery), NINDS (neurosurgery), members of the Metabolic Clinical Research Unit, Clinical Endocrinology Section, Biomedical and Metabolic Imaging Branch (BMIB), as well as with colleagues throughout the world.