U.S. Department of Health and Human Services

Kidney Disease Section

Jeffrey B. Kopp, M.D., Chief

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PodocytesPodocytes surround the glomerular capillaries; their actin-rich foot processes inter-digitate with processes from other podocytes and attach to the glomerular basement membrane. The slit diaphragms between these foot processes prevent passage of large macromolecules from plasma into the urinary space.PodocytesEnlarge
C22 PeakWe set out to find susceptibility genes for focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy, two diseases of the glomerular podocyte that are more common among African Americans. An admixture scan found an excess of African origin genetic segments in individuals with kidney disease compared to controls. The primary genetic variants that account for this admixture peak are coding variants in APOL1, encoding apolipoprotein L1.C22 PeakEnlarge