U.S. Department of Health and Human Services

Renal Diagnostics and Therapeutics Unit

Robert A. Star, M.D., Chief

​Research Images

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PCA trajectoriesThe principal component analysis of cDNA microarray data depicted demonstrates that global gene expression patterns are distinct for two different types of acute kidney injury. The trajectories reflect time-dependent divergence from the normal state.PCA trajectoriesEnlarge
Telemetry blood pressureMiniaturized pressure transducers were catheterized into mouse carotid arteries, blood pressure was monitored in conscious, freely moving mice, and data was collected by radiotelemetry. Baseline mean arterial pressure was measured over several days, revealing diurnal variation. Mouse strains C57BL/6, 129S3, and CD-1 exhibit substantial differences in baseline blood pressure.Telemetry blood pressureEnlarge
Microparticles and fibrin deposition in sepsisCalpastatin-overexpressing transgenic mice, which are protected from sepsis-induced microparticle release and mortality, have restored susceptibility to fibrin deposition in liver and lung blood vessels when microparticles are reconstituted.Microparticles and fibrin deposition in sepsisEnlarge
Dendrimer MRI as a biomarker in sepsisDendrimer MRI can be used for early diagnosis of sepsis AKI, to track the efficacy of therapeutics, and to predict mortalityDendrimer MRI as a biomarker in sepsisEnlarge