NIDDK’s core values emphasize maintaining a strong investigator initiated R01 program, preserving a stable pool of talented
new investigators, supporting key clinical studies and trials, and continuing strong support of training and career development
programs, consistent with the vision of NIDDK Director, Dr. Griffin P. Rodgers (see Vision).
At NIDDK’s May 2012 Advisory Council meeting, NIDDK’s Deputy Director, Dr. Gregory Germino, highlighted these values and
reviewed NIDDK’s resource focus on areas supporting the core values.
Following that presentation, the NIDDK generated additional data on application and funding trends to help our research community
understand application and funding dynamics over recent years and demonstrate the NIDDK’s commitment to research and
programs associated with the NIDDK’s core values and posted these data on the NIDDK website. The NIDDK updates
the charts on its website annually; the data shown here were recently updated to include Fiscal Year (FY) 2015.
NIDDK Funding Outcomes for Fiscal Year (FY) 2015 and Historical Application and Funding Trends
With the exception of Figure 8 (which includes initiative data), the data in all charts exclude initiatives (i.e., Requests
for Applications), grants funded through the Special Statutory Funding Program for Type 1 Diabetes, and funds appropriated
through the American Recovery and Reinvestment Act (ARRA).
Figure 1: Number of NIDDK competing R01 applications scoring within the top 50th percentile and number of NIDDK competing R01 applications funded in FY 2015
View enlarged Figure 1
Note: "Applications" shown in the chart above
include all applications that scored 50th percentile or better. Unscored applications, scored applications with
no percentiles, and applications scoring above the 50th percentile are not shown (48 percent [n=1,332] of the applications
received were unscored or scored above the 50th percentile). No unscored applications were funded in FY 2015.
The NIDDK nominal payline in FY 2015 was the 13th percentile for established investigators and the 18th percentile
Early Stage Investigators (ESIs). The payline and additional programmatic scrutiny for R01 applications requesting more
than $500,000 in direct costs are substantially more stringent. These data show that the NIDDK closely adheres to its
payline, but does exercise some programmatic discretion to reach for a limited number of especially innovative or programmatically
Figure 2: NIDDK Competing R01 Application Funding Curves for FY 2006-2015
View enlarged Figure 2
To generate the data for Figure 2, applications were placed into "percentile bins" as follows: Bin 1-5 includes
all applications with percentile scores from 0.1 to 5.0, Bin 6-10 includes applications with percentile scores from 5.1
to 10.0, etc. Only applications that scored 50th percentile or better were included in the analysis.
The data demonstrate steep deflections in the percentage of applications funded at the nominal payline for each year. The
R01 paylines for the years included in Figure 2 are shown in the table below.
Note: In FY 2012, the NIDDK began focusing on Early Stage Investigators
(ESIs; see definition of and benefits conveyed to ESIs on the NIH “New and Early Stage Investigator Policies”),
which is a subset of New Investigators (see also Figures 11 and 12).
Figure 3: Cumulative Percentage of R01 Awards Across Percentiles (FY 2006 – 2015)
View enlarged Figure 3
Only funded applications are considered in the data set charted in Figure 3. Percentile bin size equals one percentile and
there is no overlap between bins. Percentiles with decimal places were summed into the next highest integral percentile
as follows: 0.1-0.9 was summed into 1, 1.1-1.9 was summed into 2, etc. These cumulative funding data again demonstrate
that the vast majority of applications funded by the NIDDK fall within the payline, but that the NIDDK does exercise
some programmatic discretion to reach for a limited number of especially innovative or programmatically important applications.
Figure 4: Number of NIDDK R01 Grants (competing and noncompeting) Funded in FY 1997-2015
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Overall, the total number of R01 grants funded by the NIDDK has increased by slightly more than 20 percent since FY 1997.
The major portion of this increase occurred during the years of the NIH budget doubling (FYs 1998-2003). Over the
past 5 years, there has been a slight decline in the number of grants funded. In the past, approximately half of the
competing grants funded by the NIDDK were new (Type 1) awards, but since FY 2009 that proportion has risen to what is
now well over half.
Figure 5: Number of competing NIDDK R01 applications (including revisions) received for funding consideration in FY 1998-2015
View enlarged Figure 5
Figure 5 shows a substantial increase in the number of competing R01 applications received by the NIDDK between FYs 1998
and 2006. After approximately 5 years of relatively flat growth prior to FY 2013, the number of applications increased
in FYs 2013-2015. Much of the observed increase between FY 1998 and FY 2006 and between FY 2013 and FY 2015 was
largely due to new (Type 1) applications. Submission rates for competing renewal applications fluctuated somewhat between
FY 1998 and FY 2014, but, overall, the numbers of renewal applications have remained relatively flat. It should
be noted that only one amendment and resubmission of an application was allowed after January 25, 2009. The full implementation
of the NIH policy eliminating a second amended application is coincident with a rise in “New” competing R01 applications
in FY 2010.
Figure 6: Overall NIDDK expenditures (includes direct and facilities and administrative costs) on R01 awards (competing and
non-competing) in FY 1995-2015
View enlarged Figure 6
Figure 6 shows that NIDDK expenditures on R01 grants have increased markedly (147 percent) since FY 1995. This is because
the NIDDK is funding a larger number of these awards (Figure 4) and also because the median cost of an R01 has increased
substantially (Figure 7).
Figure 7: Median Total Costs (includes direct and facilities and administrative costs) of NIDDK R01 Grants (competing and
non-competing) in FY 1995-2015
View enlarged Figure 7
Figure 7 illustrates that the median cost of R01 awards has increased approximately 85 percent since FY 1995. Since
FY 2004, the number of grants receiving $500,000 or more in total costs has gone from 5 percent of the total number of
awards to 19 percent of the total awarded R01s. The number of grants receiving $250,000 or less in total costs has declined
from 20 percent of the total awards to 8 percent.
Figure 8: NIDDK Extramural research funding by category (Competing and Non-Competing)
View enlarged Figure 8
Figure 8 shows that relative funding levels of most NIDDK extramural research categories have remained fairly stable since
FY 2003. These data were presented to the NIDDK’s Advisory Council in May 2012 in the context of the NIDDK’s core
values. The NIDDK core values emphasize maintaining a strong investigator initiated R01 program, preserving a stable
pool of talented new investigators, supporting key clinical studies and trials (support is generally represented in the
Initiatives and Contracts categories), and continuing strong support of training and career development programs. Figures
9 to 12 illustrate other examples of how the NIDDK's portfolio has reflected NIDDK core values over time.
NIDDK Portfolio Categories:
- R01 – Investigator Initiated (excludes R01s responding to NIDDK RFAs)
- Other R – Includes other R activities (i.e., R03, R13, R15, R18, R21, R34, SBIR/STTR, etc), but excludes
R24s and applications submitted to NIDDK RFAs
- Initiatives – Awards made in response to NIDDK RFAs; includes most NIDDK large clinical trials and consortia.
- Collaborative Grants – P01s and R24s that are not "mini-Centers"
- Centers – Includes all non-P01 P awards and R24 "mini-Centers"
- Career Development – Includes all Ks (including K99/R00)
- Training – Includes all F and T activities
- Other Research – Everything not captured in the categories above
- Contracts and Interagency Agreements (IAAs)—Includes some large clinical studies
Figure 9: Maintaining a Stable Pool of NIDDK Investigators: Number of Investigators Supported by at Least one R01
View enlarged Figure 9
Figure 9 shows that the number of Principal Investigators (PIs) supported by at least one R01 remained relatively stable
between FYs 2003 and 2009. In FYs 2010 and 2011, there were increases in the numbers of PIs supported with an NIDDK R01.
It should be noted that in FY 2008 NIH, for the first time, began making multiple principal investigator R01 awards to
support team science projects. The observed increases in numbers of PIs supported by the NIDDK in FYs 2010 and 2011 are
largely attributable to multiple principal investigator R01 awards. The subsequent declines in FYs 2012-2015 are likely
due in large part to paylines that became more stringent (i.e., after FY 2011) and inflationary pressures in the context
of flat or declining budgets.
Figure 10: Preserving a Stable Pool of New Investigators: Number of NIDDK New Investigator R01 Applications and Awards
View enlarged Figure 10
Figure 10 shows that while application rates for New Investigators have remained fairly high, there was a deceleration in
the number of New Investigator awards between FYs 2003 and 2006. Starting in FY 2007, the NIH and the NIDDK established
new policies focused on New Investigators and these policies appear effective in mitigating downward pressures on New
Investigator awards. The decrease in number of New Investigator awards in FY 2012 reflects a decrease in the number of
applications from New Investigators that year. Numbers of New Investigator applications and awards recovered somewhat
in FY 2013 through FY 2015, although in FY 2015 the number of New Investigator awards did not keep pace with increased
numbers of applications and in fact there was a slight decline in the number of New Investigator awards. In addition,
in FY 2012 NIH and NIDDK began focusing on Early Stage Investigators (ESIs; see definition of and benefits conveyed to
ESIs on the NIH “New and Early Stage Investigator Policies”),
which is a subset of New Investigators (see table associated with Figure 2 and Figures 11 and 12). It should be noted
that the data in this chart count applications and awards, not persons.
Figure 11: Preserving a Stable Pool of New Investigators: Number of NIDDK Early Stage Investigator (ESI)
R01 Applications and Awards
View enlarged Figure 11
Comparison of Figures 10 and 11 shows that while the subset of ESI applications fell in FY 2012 essentially in proportion
to the total drop in New Investigator applications, the proportional drop in number of awards to ESIs was not as great.
This is attributable in part to the NIDDK’s differential payline for ESI applications (see Figure 2 and the “NIDDK Policies
Related to First-Time Investigator Support” at http://grants.nih.gov/grants/new_investigators/index.htm).
The number of ESI awards in FY 2013 was essentially flat compared with the number of ESI awards in FY 2012, and the number
of ESI awards in FY 2014 increased approximately 54 percent compared to FY 2013 ESI award numbers. In FY 2015,
the number of ESI awards dipped slightly compared to FY 2014; however the number of ESI awards in FY 2015 remains over
30 percent higher than the number in FY 2013.
Figure 12: Preserving a Stable Pool of New Investigators: Percent of New Investigator Applications and Awards that are ESI
View enlarged Figure 12
Figure 12 shows that the NIDDK’s differential payline for ESIs from FY 2012 to FY 2015 (see Figure 2 and the “NIDDK Policies
Related to First-Time Investigator Support” at http://grants.nih.gov/grants/new_investigators/index.htm)
has been effective in continuing to enhance ESI representation among New Investigator awards.
Figure 13: Support Pivotal Clinical Studies and Trials: NIDDK Human Subjects Research Funding as a Proportion of All Extramural
View enlarged Figure 13
Figure 13 demonstrates that the NIDDK commits a substantial proportion of its research funding to the support of clinical
research involving human subjects. For the purpose of this analysis, we used the definition described in Kotchen et al,
JAMA 2004 Feb; 291(7):836-43 and included all studies coded as using Human Subjects (HS+).
Figures 14A to 14D: The NIDDK Is Committed to Training the Next Generation
Figures 14A to 14D demonstrate that the NIDDK’s commitment to training and developing the careers of the next generation
of scientists remains strong. Figure 14A shows that overall support of training and career development programs has increased
since FY 2003 and that the slight deceleration of T awards support was offset by an increase in support of F awards (by
design). Figures 14B and D illustrate that the numbers of NIDDK T awards and associated training slots have decreased
somewhat since FY 2012 as the NIDDK enhanced support of F awards. Figure 14C shows that while the numbers of NIDDK K08
(Mentored Clinical Scientist Development Award) awards decreased between FYs 2003 and 2013, the numbers of K01 (Mentored
Research Scientist Development Award) and K23 (Mentored Patient-Oriented Research Career Development Award) increased.
The NIDDK will continue to monitor carefully its training and career development programs to ensure appropriate
Figure 14A. NIDDK Fellowship (F), Career Development (K), and Training (T) Awards as a Percent of Total Research Funding
View enlarged Figure 14-A
Figure 14B. Number of NIDDK Fellowship (F), Career Development (K), and Training (T) Awards by Fiscal Year
View enlarged Figure 14-B
Figure 14C. Number of NIDDK Career Development (K) Awards by Activity and Fiscal Year
View enlarged Figure 14-C
Figure 14D. Number of NIDDK Training (T32) Award Slots by Fiscal Year
View enlarged Figure 14-D
Note: T32 awards made in FY 2015 continue into FY 2016. The total numbers of T32 slots are reported at the
end of the award period. Therefore, the FY 2015 information on T32 slots will not be available until later in FY 2016;
thus, unlike the previous charts, FY 2015 data are not included here.