U.S. Department of Health and Human Services

Acute and Chronic Pancreatitis

Pancreatitis is a syndrome that is characterized by pain associated with inflammation and damage to the pancreas.  Relapsing or chronic pancreatitis can lead to exocrine and endocrine pancreatic insufficiency.  Major causes of pancreatitis are alcohol use, cholelithiasis, drug toxicity, and infections.  In some cases there may be a genetic basis; however, a significant percentage of cases are idiopathic.

The Acute and Chronic Pancreatitis program supports a broad range of research topics on the etiology and pathogenesis of acute and chronic pancreatitis.  Some examples are:  the elucidation of mechanisms by which alcohol and drugs induce or promote premature activation of pancreatic enzymes (zymogens) within the pancreas directly or indirectly; the determination of the role of diet, including fat and protein, in the modulation of gene expression and synthesis of various secretagogues; the roles of cytokines, chemokines, adhesion molecules, and inflammatory leukocytes in the initiation and progression of inflammation of the pancreas; the characterization of the molecular mechanisms of pancreatic stellate cell activation leading to increased deposition of extracellular matrix proteins and fibrosis; the characterization of the relationship between pancreatitis, diabetes, obesity, and pancreatic cancer; and the identification and characterization of biomarkers of early cell or tissue perturbation that can be used for diagnosis of the disease.​

 NIDDK Staff

Jose Serrano, M.D., Ph.D.Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/25/2016Limited Competition: Research Resource for Human Organs and Tissues (U42) (Summary) RFA-OD-17-001
11/23/2016NIH Health Care Systems Research Collaboratory - Demonstration Projects for Pragmatic Clinical Trials (UG3/UH3) (Summary) RFA-RM-16-019
10/27/2016NIDDK Exploratory Clinical Trials for Small Business (R44) (Summary) PAR-17-034
10/19/2016Addressing Health Disparities in NIDDK Diseases (R01) (Summary) PA-17-021
10/11/2016Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3) (Summary) RFA-TR-16-017
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

NIDDK Repository for Biosamples and Data

Supports Data, Biosample, and Genetic Repositories to increase the impact of current and previously funded NIDDK studies by making their data and biospecimens available to the broader scientific community. These Repositories enable scientists not…

Type 1 Diabetes TrialNet

Type 1 Diabetes TrialNet (TrialNet) is an international network of researchers who are exploring ways to prevent, delay and reverse the progression of type 1 diabetes.

Study of Nutrition in Acute Pancreatitis

SNAP is a randomized multi-center clinical trial designed to test whether duodenojejunal (DJ) feeding is more effective than nasogastric (NG) feeding in providing enteral nutrition to patients with severe acute pancreatitis. SNAP will enroll…

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 NIDDK Active Trials in Pancreatic Disease

​View related clinical trials from ClinicalTrials.gov​.​


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.​

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​