U.S. Department of Health and Human Services

Clinical Research in Type 2 Diabetes

The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at understanding, preventing and treating type 2 diabetes (T2D). This program includes clinical trials that test pharmacologic, behavioral, surgical or practice-level approaches to the treatment and/or prevention of T2D, including promoting the preservation of beta cell function. Studies may also advance the development of new surrogate markers for use in clinical trials. Studies can be designed to understand the pathophysiology of T2D, including the role of gestational diabetes and metabolic imprinting on the development of T2D, as well as factors influencing the response to treatment. The program also encompasses epidemiologic studies that improve our understanding of the natural history and pathogenesis of T2D, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes, especially in the pediatric population. The program also supports research to test approaches to reduce racial/ethnic disparities in the incidence and/or clinical outcomes of T2D.​​​​​


 NIDDK Staff

Andrew Bremer, M.D., Ph.D.Clinical studies in (1) gestational diabetes and maternal outcomes, and (2) HIV/AIDS-associated metabolic and endocrine dysfunctionChristine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes Translational ResearchChristine Lee, M.D., M.S.Clinical studies on the development, diagnosis and medical treatment of type 2 diabetes in adults; clinical studies of diabetes in older adultsBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in children, youth and adults; human studies of metabolic imprinting
Peter J. Savage, M.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complicationsKaren L. Teff, Ph.D.Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes


 Related Funding Opportunities

Posted DateTitleFull Announcement
10/7/2016BD2K Support for Meetings of Data Science Related Organizations (U13) (Summary) RFA-CA-16-020
8/24/2016Big Data to Knowledge (BD2K) Enhancing the Efficiency and Effectiveness of Digital Curation for Biomedical Big Data (U01) (Summary) RFA-LM-17-001
8/17/2016Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01) (Summary) RFA-DK-16-005
8/16/2016Big Data to Knowledge (BD2K) Community-based Data and Metadata Standards Efforts (R24) (Summary) RFA-ES-16-010
8/10/2016BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25) (Summary) RFA-ES-16-011
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…

View Additional Research Resources


 NIDDK Active Trials in Type 2 Diabetes

​View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​from the NIH's Center for Scientific Review.