U.S. Department of Health and Human Services

Clinical Research in Type 2 Diabetes

The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at understanding, preventing and treating type 2 diabetes (T2D). This program includes clinical trials that test pharmacologic, behavioral, surgical or practice-level approaches to the treatment and/or prevention of T2D, including promoting the preservation of beta cell function. Studies may also advance the development of new surrogate markers for use in clinical trials. Studies can be designed to understand the pathophysiology of T2D, including the role of gestational diabetes and metabolic imprinting on the development of T2D, as well as factors influencing the response to treatment. The program also encompasses epidemiologic studies that improve our understanding of the natural history and pathogenesis of T2D, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes, especially in the pediatric population. The program also supports research to test approaches to reduce racial/ethnic disparities in the incidence and/or clinical outcomes of T2D.​​​​​

 

 NIDDK Staff

 
Andrew Bremer, M.D., Ph.D.Clinical studies related to type 1 and 2 diabetes; gestational diabetes and maternal outcomes; HIV-associated metabolic/endocrine dysfunctionChristine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes Translational ResearchChristine LeeDiabetes in special populations including the elderlyBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in children, youth and adults; human studies of metabolic imprinting
Peter J. Savage, M.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications.Karen L. Teff, Ph.D.Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/28/2016Limited Competition: Continuation of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study (U01) (Summary) RFA-DK-16-511
7/21/2016Assay Development and Screening to Discover Therapeutic or Imaging Agents for Diseases of Interest to the NIDDK (R01) (Summary) PA-16-374
7/20/2016Promoting Organ and Tissue Donation Among Diverse Populations (R01) (Summary) RFA-DK-16-022
6/15/2016Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01) (Summary) PAR-16-333
6/15/2016Neurocognitive Effects of Glycemic Dysregulation in Type 1 Diabetes (DP3) (Summary) RFA-DK-16-007
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…

View Additional Research Resources

 

 NIDDK Active Trials in Type 2 Diabetes

 
​View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections ​from the NIH's Center for Scientific Review.