U.S. Department of Health and Human Services

Cystic Fibrosis

The Cystic Fibrosis Research program supports both basic and clinical studies on the etiology, molecular pathogenesis, pathophysiology, diagnosis, and treatment of cystic fibrosis and its complications.  These studies examine the characterization of the cystic fibrosis gene, its mutations, and the molecular mechanisms by which mutations cause dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR) protein.  Also included are studies aimed at the elucidation of electrolyte transport pathways in affected epithelia, their relationship to the CFTR, and research on the potential roles of CFTR in the transport of molecules in critical cellular processes.  The ultimate goal of these mechanistic studies is to develop therapies that modulate the transport defect and improve the functioning of mutant CFTR.  Other research is conducted to determine the relationship between genotype and phenotype (e.g., variable clinical presentations and severity of disease) and to delineate the mechanisms underlying the disease’s characteristic inflammation and infection, with the ultimate goal of developing safe and effective methods of therapy for individuals with cystic fibrosis.​​​​​​​​​​​​​​​​​

 

 NIDDK Staff

 
Thomas Eggerman, M.D., Ph.D.Cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation
Yan Li, Ph.D.Small Business Technology Development, DEM K99/R00 Pathway to Independence Awards and R13 Conference Grants

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
1/17/2017Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01) (Summary) PAR-17-123
1/5/2017Research on the Health of Women of Underrepresented, Understudied and Underreported (U3) Populations An ORWH FY17 Administrative Supplement (Admin Supp) (Summary) PA-17-101
12/23/2016Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp) (Summary) PA-17-098
12/12/2016Administrative Supplement for Research on Sex/Gender Influences (Admin Supp) (Summary) PA-17-078
11/25/2016Limited Competition: Research Resource for Human Organs and Tissues (U42) (Summary) RFA-OD-17-001
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Mouse Metabolic Phenotyping Centers

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

NIDDK Repository for Biosamples and Data

Supports Data, Biosample, and Genetic Repositories to increase the impact of current and previously funded NIDDK studies by making their data and biospecimens available to the broader scientific community. These Repositories enable scientists not…

View Additional Research Resources

 

 NIDDK Active Trials in Cystic Fibrosis

 
​View related clinical trials from ClinicalTrials.gov​.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.