U.S. Department of Health and Human Services

Diabetes and Metabolism HIV/AIDS

The Diabetes and Metabolism HIV/AIDS program supports innovative basic science and clinical research on the role of HIV infection, including relevant host conditions, or antiretroviral therapy (ART) on metabolic and endocrine dysfunction. Specific areas of support include, but are not limited to:
•   Studies to elucidate the mechanisms underlying the effects of HIV and/or ART on metabolism (including glucose, lipid, and skeletal metabolism), body composition, and general endocrine function through basic and clinical research
•   Studies that elucidate novel approaches to prevent or manage diabetes and/or other endocrine disorders in HIV-infected individuals. However, such studies should target pathways unique to the development of these disorders in the context of HIV infection and/or its treatment rather than simply testing treatments accepted in non-HIV-infected individuals
•   Studies that elucidate the interactions between HIV, ART, and/or HIV-associated inflammation and diabetes-related medications to provide a basis for individualized therapy
•   Studies that determine the extent to which HIV and its therapy increase the risk of diabetes and/or other endocrine or metabolic dysfunction and identify factors which augment or ameliorate the risk
•   Studies that discover and validate biomarkers for metabolic and/or endocrine disease progression as a result of HIV infection or its treatment
•   Studies that employ non-invasive or minimally invasive means to assess tissue-specific or whole body metabolic changes in vivo due to HIV infection or therapy​​​​​​


 NIDDK Staff

Andrew Bremer, M.D., Ph.D.Clinical studies in (1) gestational diabetes and maternal outcomes, and (2) HIV/AIDS-associated metabolic and endocrine dysfunction


 Related Funding Opportunities

Posted DateTitleFull Announcement
2/1/2017Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42) (Summary) PA-17-148
2/1/2017Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44) (Summary) PA-17-147
1/24/2017Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44) (Summary) PA-17-130
1/24/2017Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R41/R42) (Summary) PA-17-131
1/17/2017Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01) (Summary) PAR-17-123
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Mouse Metabolic Phenotyping Centers

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…

View Additional Research Resources


 NIDDK Active Trials in HIV/AIDS

View related clinical trials from ClinicalTrials.gov​.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​